Unlocking your genome

The documentary, “Cracking your Genetic Code”, gave a fairly comprehensive look into the world of DNA sequencing and issues related with this practice. Often times, when we think of genome sequencing, the movie GATTACA comes to mind which has led many to believe that we can tailor individuals to have certain characteristics. Yet, this is far from the truth as our understanding of how genes operate is still not complete and instead we can only give probabilistic estimates. However, the most important question this documentary provoked was one that I struggled with for a couple days, “Do you want you genomes sequenced?” The examples provided in the documentary showed both sides of the dilemma. On one hand, through genome sequencing, doctors and researchers are able to gather even more information. On the other hand, many individuals don’t want their genomes sequenced in the hopes of not finding they have a high risk of a life altering disease. Moreover, many are concerned about the confidentiality of the results of their personal genome and I think this the most pressing dilemma. If employers have access to these results and can make hiring decisions based off them, many will be deterred from getting their genome sequenced. Thus, as startups become more sophisticated and sequencing becomes more common, we have to work together to create safe laws and guidelines to ensure confidentiality.

Personally, I feel that genome sequencing should become common practice in the coming years as the benefits far outweigh the costs. Allowing doctors to gain more data will help further advance medicine and create a healthier future for all.

 

 

Looking Under the Surface

The film this week was a NOVA documentary about the ethics and future of DNA testing. This documentary pairs nicely with a class I’m currently taking, Ethical Issues in Medicine and Science. As my professor in that class has said, technology isn’t automatically ethical. People are required to decide the morally acceptable ways in which to use technology. And often scientists are not the ones best qualified to make those ethical decisions. Lawyers, politicians, representatives of science, and common people must come together to search for the answers. Specifically for genetics the stakes are higher than any other science. As we learn more about how genes control our bodies, it becomes tempting to want to make small modifications to fix genetic diseases before they start. However, once that becomes a reality parents will want to use the power of genetics to modify their babies to have blue eyes or to be tall or to be incredibly intelligent. Genetic engineering is  dangerous tool for which the ethics need to be dealt with quickly. Curing diseases is obviously a good thing, and I think genetic engineering is a good way to provide treatment. But that is where genetic modifications must stop. Using genetics to “treat” unfavorable traits like bad eyesight will probably be possible but can lead to unintended consequences. The elephant in the room when talking about this subject is eugenics and the scary things people will do to make a “perfect” human. Therefore, genetic modifications should be used to treat life threatening diseases, and stop there. Trying to mess with traits people consider unfavorable is far too dangerous to be unregulated.

Do you really know yourself

This movie, NOVA, introduces the decoding of human genes and the impact of this technology.

Even a 5-year-old child, who never took any biology class, would probably be able to tell that DNA includes all the information that makes a human. Meanwhile we know very little about the information encoded. After decades of research, the scientists can now indentify the protean types of the numerous pairs on the DNA chain. Yet, we still have limited understanding on how these protean relate to our biological features. Luckily we are now already able to utilize the limited knowledge to improve human welfare, especially in medicine. Reearchers in the area believe that human will be able to completely manipulate these genetic information, i.e. modify what makes up us.

Thrilled by the wonder of science, we still need to consider the ethical side of this development. Should each indiviual have access to his/her own DNA info, and how can we protect the privacy of such info? If we can just genetically modify our descedents, what are the moral issues that come with it?

I personally think that we should consider this problems without stopping our studies becuase the benefits are irresistable. Would not it be great to not having illness or birth-defects anymore?

 

Where Does Our Fear of Disease Come From?

The scientific film-Cracking Your Genetic Code inspired me to reconsider the meaning of fear. If someone got a disease, does his fear come from the suffering from guessing, planning or imaging his unpredictable future or the real disease causes him to suffer. In other words, people may tend to think those who got diseases are poor because they have to suffer from the pain caused by the disease and they might have a shorter or more restricted life compared with normal people. However, the suffer of someone’s guessing before he or she was ‘officially’ informed to have a disease is also painful, or even more painful sometimes. Some people choose to suicide not because they have the disease but probably because they are tired of the mental breakdown or nervous tension. They just want to get rid of the ‘mental disease’.

Then, as the film introduced, our society is going to develop a technique by which people can foresee their disease by checking their genetic code. Of course, it is a powerful method and one of the most significant scientific movements which is great to our society. However, if we reconsider the information the technique provide, are we actually willing to take it? Are you feeling better if you were told that your genes said that you would have a disease? It is good for the genes to be ‘transparent’ to me but sometimes I would rather choose to stay unknown and foolish since sometimes, the fear from disease is from the fear of having the disease.

Decoding Your Genome

Last Friday, I watched a documentary about whole genome sequencing; it’s benefits and consequences. A good portion of the film was focused on the use of medically driven whole genome sequencing for diagnosing and treating conditions. This involved background information about illnesses, case studies and potential future applications of genotyping.

While most of this may seem like the stuff of research labs and investigators, genotyping is fairly accessible to the general population. There are a large number of companies that provide genetic information based on samples that have been submitted to them. They usually focus on specific genes and traits, as opposed to providing a whole ‘map’ of an individual’s genome.

Initially, these tests were considered ‘fun’ activities. They provided information about ancestry, or certain quirky facts. However, companies like 23andMe have focused on also presenting customers with information about genetic predispositions to illnesses and conditions.

With a $99 fee for a test, shipping and ~8 week wait, 23andMe is arguably the most convenient method of finding out more about genetic predispositions. It may be beneficial, as 23andMe is now offering to detect genetic predispositions for late-onset Alzheimer’s by analyzing the APOE gene.  This is useful since research has indicated that specific mutations in this gene may in an increased likelihood of developing late onset Alzheimer’s. It would difficult information to learn of but it would provide individuals knowledge that they may find useful/want in planning for their future.

However, these results may not always be helpful or accurate. Even though 23andMe states that they do not provide diagnostic testing, customers may often view their results as a diagnosis. They may take measures into their own hands, without consulting a professional about further testing or medical options. This is unsafe since a significant number of conditions are not caused only by genetics, but also by the environment and other factors.

Keeping that in mind, tests like these have both benefits and consequences on an individual’s level. There are more issues when looking at the broader picture: like the aggregation of genetic information and the potential benefits and risks associated with such databases.

The Human Genome, the key to our salvation, or our misery?

This past Friday I watched a documentary about cracking the code of life, DNA. The documentary itself focused on the idea that the human genome presents the answers to most of life’s mysteries and that by doing full DNA sequencing we can potentially save the lives of thousands of people. However, it also raises many ethical questions. Will genomics eventually lead to designer children? Is it reckless to give people access to their entire genomes? What will happen if insurance companies or employers find something undesirable in an applicants genome? All of these are extremely valid questions that should be addressed before attempting to reach an answer on whether or not genomics is practical and ethical. However, one should not ignore the amazing medical potential genomics and DNA sequencing has.

In the documentary, it they discuss how DNA sequencing has helped saved the lives of many, including two twins born with health issues. Standard medical diagnoses could not help the children and had they not underwent DNA sequencing it is very possible they would have died by now. However, DNA sequencing allowed scientists and doctors to find irregular letters in their genetic pattern. By prescribing medicine to correct this irregularity the twins eventually saw an incredible change eventually becoming fully fledged healthy adults. All of this would have been impossible without genomics and thus for this reason I believe that genomics is extremely beneficial. However, as mentioned I believe it also has some drawbacks.

In the case of those with Huntington’s disease there is nothing that can be done even if they are found to have the gene linked to the disease. It is cases like these that make me question whether or not genomics is really ethical. If one discovers that they have the gene then they are left with no choice but to wait until the symptoms begin to appear. One could argue that this would allow the person to go out and enjoy life as much as possible until that time, but on the other hand it could send a person into a very deep depression. Additionally, there are many other genes that could potentially “increase” a persons risk for a certain disease which could effect both their mental health as well as their job and insurance opportunities if this data was to fall into the wrong hands.

Overall, the documentary really made me question something for the first time in a while. Typically when you see something in the news you might be influenced to think one way or the other, but after a few minutes you will probably forget all about it. In this case I feel as though the documentary laid out both the pros and cons of genomics and presented it in such a way that forces the topic to remain on your mind. I believe that due to this the documentary is extremely effective at conveying the information it wants people to know but also allows for the topic to enter into the front lines of discussion by providing people with the opportunity to make up their own opinions after having heard facts for both sides of the argument.

Knowledge vs. Fear

I found the documentary enlightening, partly because I was unaware that science, technology, and the database of information on what genes influence specific conditions had progressed as far as being able to predict so much about our personal experiences at different stages in life. Yet, I was, as one of the women in the film, a little disturbed that so much information could be readily available to me if I so wish. Much like in statistics, where newfound information can tell you much about the probability of related events, knowing our genetic information can influence the probability of the actions we take in the future.

In light of this, I would like to consider Nelson Mandela’s words, “May your choices reflect your hopes, not your fears.” I am of the belief that fear is a strong motivator for our actions, yet I do not want to reflect on my life decisions knowing they were based on all the worst case scenarios instead of the best of opportunities available to me.  If the fear is there for someone who would like to minimize their risk of certain conditions, life-style choices could be made, independently of genetic information available, to  avoid such conditions. I realize that this theory does not account for certain conditions that we are unaware we are at risk of, but some those conditions are typically a result of family history that most people are generally aware about.

I believe that a little ignorance about our future can go a long way in helping us remain rational, hopeful, and happy. Would you want to know about an imminent condition despite your inability to take action in regards to its prevention? Would this knowledge put avoidable stressors on your life with thoughts of what hurdles may lay ahead in your future? Would you want to worry for the rest of your life about the possibility of developing a condition that you may never get? While I can appreciate the advancements that modern medicine can make with the knowledge of a human’s genome, these are also important things to consider when it comes to the repercussions of our curiosity.

 

 

The Implications of Knowing More

Tonight, I saw a Nova film about the future of genome testing. I think it was a very interesting presentation about the positives and negatives of this uncertain scientific terrain. It portrayed several situations in which people regretted getting tested and others refused to be tested. In both situations, there were drawbacks. This film made me realize the difficulty of decisions many people are going to have to make in the future. It also made me question whether humankind should have access to this kind of technology and knowledge. Further on in the film, experts stated the potential implications of having people’s genetic codes made public. It could lead to discrimination.

All of these drawbacks make genetic testing seem villainous. However, the medical success stories shown in the film also highlight the positive effects. Children’s lives were significantly changed because of testing. They were able to diagnose rare diseases and develop medicines to help combat them. In some cases where the patients were older, there was less genetic testing could do. This makes me think that if genetic testing were to become normal, it would start at birth. However, this also has negative implications for these children. The stigma of a disease they cannot predict or treat could follow them around for their entire life.

Overall, it seems that genetic testing is a very difficult terrain to travel. I feel as if all of these conflicting views and stories make it extremely difficult for me to pick a side. I think that the world is going in the direction of using genetic testing regularly and fear of the unknown is mounting as time goes on and new discoveries are made. How do we know the implications of knowing more? It seems to be an impossible question to answer.

Decoding our Genetics

The NOVA episode Cracking Your Genetic Code brings to light a lot of interesting topics. One I found specifically fascinating was do we want to find things out about ourselves via genetic testing? Personally while I think it would be fascinating I think a lot of people would turn into hypochondriacs. I don’t really want to know what my risk of developing a certain disease is. I could spend my entire life worrying about a disease that I may never actually contract. The film brought up another good point from the opposite point of view if I am at a lower risk for developing heart disease my lifestyle choices may change leg. eating high fat foods which would increase my risks. If you spend your whole life worrying about a disease or condition you may have in the future and worry about it now whether or not you get the disease it has ruined your life because you were obsessing about it. Also the idea of privacy. Your DNA is unique to you and potential having your genetic results end up as a matter of public record one day is scary. Right now DNA testing  for research is anonymous but genetic testing could be used against you. If you have a high risk of developing a disease you might be denied health insurance and with all the problems already occurring with healthcare in the United States do we really need more problems?