I few days ago, I went to the Rose House Fellows meet and greet. We got a couple minutes or so to talk to each fellow, and rotate through as many people as possible over an hour. Having just transferred from a small, liberal arts college in Southern California I still do not know much about Cornell, so the meet and greet was perfect for me. I learned about Ithaca’s weather, Cornell’s gorges, psychology, and most notably, quantum biology.
Though I was only at the event for an hour or so, it has left a lasting impression on me. I feel very welcomed here, and I got to talk to many new people that I otherwise would not have met. I also feel inspired to expand my mindset regarding the classes I plan to enroll in and careers I’m considering. I had conversations with fellows in all areas in academia, such as latin, philosophy, evolution, and psychology. Each person was clearly passionate about their own work, and it made me realize that I should not limit my future goals based on a decision I made years ago. I chose to major in biological sciences, for instance, because it seemed like a safe, unrestrictive option that covered a breadth of sub-topics (none of which I could choose between). I am also on the pre-med track because I have always wanted to help people, and being a doctor seemed like the most obvious way to do that. However the fellows’ passion in their niche subject was contagious and I now feel inclined to dabble in those subjects here at Cornell. Unlike my previous college, Cornell has courses in food science, animal science, and plant biology; and with only five semesters left after this one, I can’t wait to start adding some of these more specialized courses into my schedule very soon.
My most memorable discussion was with Professor Andre Kessler, from the Department of Ecology and Evolutionary Biology. He opened up the world of quantum biology to me — a subject I didn’t know existed. Physics is pretty much the underlying fabric of the universe, so if it applies to planets and basketballs, it ought also to effect receptors and their associated ligands. Apparently, quantum biology may help elucidate a facet of biochemistry that is still cloudy. Kessler told me that at this point, there are only mathematical explanations for some of these abstract mechanisms. One such example is the odor receptors in our nose: they are membrane-bound receptors that change conformation just like any other receptor. It changes conformation after an interaction with a stimulus, with an electron transfer typically involved. In the case of the odor receptors, he said, the mechanism is still obscure, because it is thought to involve this quantum biology, specifically something called “electron tunneling.”
According to Kessler, part of the reason why we don’t know much about this mechanism is because we haven’t yet fleshed out exactly what the receptor looks like — it’s 3D conformation is unknown. To do this, electron microscopy imaging is typically employed. However, the membrane protein involved in odor perception cannot be deciphered when it is taken out of its natural context, and covered in gold (which is how the object under the electron microscope is stabilized while it is bombarded with high energy rays). Fortunately, Kessler mentioned new technology that is able to match the resolution of electron microscopy, but without the obstructive gold covering as a pre-requisite, called cyromicroscopy. The new technology utilizes zero degrees kelvin as a stabilizing mechanism. It hasn’t yet been applied to this receptor in question, but it could be in the future, and the ripple effect of that could be impactful.
I was lucky that Professor Kessler was the last fellow on the rotation, because I got to ask him a lot of questions about all of this science he knew about that I didn’t even know existed! I was impressed by the degree of complexity and detail many scientists work with. I hope to continue learning from future events to come!
-Hana