Article: Singh A, Agarwal R, Diaz-Ruiz CA, Willett NJ, Wang PY, Lee La, Wang Q, GUldberg RE, Garcia AJ; (2014) “Nanoengineered Particles for Enhanced Intra-Articular Retention and Delivery of Proteins”, Advanced Healthcare Materials, 3 (10): 1562-1567
Abstract: Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.