SELECTED PUBLICATIONS

Shioda T, Weiss RS, Bagrodia A, Frazier AL. Comment on “Comment on ‘A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen'”. Environ Health Perspect. 2023 Dec;131(12):128001. doi: 10.1289/EHP14247. Epub 2023 Dec 15. PMID: 38099920; PMCID: PMC10723136. Pubmed.

Loehr AR, Timmerman DM, Liu M, Gillis AJM, Matthews M, Bloom JC, Nicholls PK, Page DC, Miller AD, Looijenga LHJ, Weiss RS. Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection. bioRxiv [Preprint]. 2023 Sep 12:2023.09.09.556995. doi: 10.1101/2023.09.09.556995. Pubmed.

Erstling JA, Bag N, Gardinier TC, Kohle FFE, DomNwachukwu N, Butler SD, Kao T, Ma K, Turker MZ, Feuer GB, Lee R, Naguib N, Tallman JF, Malarkey HF, Tsaur L, Moore WL, Chapman DV, Aubert T, Mehta S, Cerione RA, Weiss RS, Baird BA, Wiesner UB. Overcoming Barriers Associated with Oral Delivery of Differently Sized Fluorescent Core-Shell Silica Nanoparticles. Adv Mater. 2023 Sep 9:e2305937. doi: 10.1002/adma.202305937. Pubmed.

Pereira C, Arroyo-Martinez GA, Guo MZ, Downey MS, Kelly ER, Grive KJ, Mahadevaiah SK, Sims JR, Faca VM, Tsai C, Schiltz CJ, Wit N, Jacobs H, Clark NL, Freire R, Turner J, Lyndaker AM, Brieno-Enriquez MA, Cohen PE, Smolka MB, Weiss RS. Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. (2022) eLife 2022;11:e68677. Pubmed.

Kobayashi M, Kobayashi M, Odajima J, Shioda K, Hwang YS, Sasaki K, Chatterjee P, Kramme C, Kohman RE, Church GM, Loehr AR, Weiss RS, Jüppner H, Gell JJ, Lau CC, Shioda T. Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers. (2022) Stem Cell Reports 2022 Feb 1;S2213-6711(22)00056-X. Pubmed.

Zhang, S., Nelson, O. D., Price, I. R., Zhu, C., Lu, X., Fernandez, I. R., Weiss, R. S., & Lin, H. Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis. (2022) Proceedings of the National Academy of Sciences of the United States of America, 119(11), e2117013119. Pubmed.

Sims JR, Faça VM, Pereira C, Ascenção C, Comstock W, Badar J, Arroyo-Martinez GA, Freire R, Cohen PE, Weiss RS, Smolka MB. Phosphoproteomics of ATR signaling in mouse testes. (2022) eLife Feb 8;11:e68648. Pubmed. 

Shah P, McGuigan CW, Cheng S, Vanpouille-Box C, Demaria S, Weiss RS, Lammerding J. ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels. (2022) Front Cell Dev Biol. Jun 1;10:875132. Pubmed.

Latifkar, A., Wang, F., Mullmann, J. J., Panizza, E., Fernandez, I. R., Ling, L., Miller, A. D., Fischbach, C., Weiss, R. S., Lin, H., Cerione, R. A., & Antonyak, M. A. IGF2BP2 promotes cancer progression by degrading the RNA transcript encoding a v-ATPase subunit. (2022) Proceedings of the National Academy of Sciences of the United States of America, 119(45), e2200477119. Pubmed. 

Fonseca, A., Lobo, J., Hazard, F. K., Gell, J., Nicholls, P. K., Weiss, R. S., Klosterkemper, L., Volchenboum, S. L., Nicholson, J. C., Frazier, A. L., Amatruda, J. F., Bagrodia, A., Lockley, M., & Murray, M. J. Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium. (2022) British journal of cancer, 127(9), 1577–1583. Pubmed. 

Abril, Y.L.N, Fernandez, I.R., Hong, J.Y., Chiang, Y.-L., Kutateladze, D.A., Zhao, Q., Yang, M., Hu, J., Sadhukhan, S., Li,B., He, B., Remick, B., Bai, J.J., Mullmann, J., Wang, F., Maymi, V., Dhawan, R., Auwerx, J., Southard, T., Cerione, R., Lin, H., and Weiss, R.S. (2021) Small molecule inhibition and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene 40:1644-1658. Pubmed. 

Loehr A.R., Pierpont T.M., Gelsleichter E., Galang, A.M.D., Fernandez, I.R., Moore, E.S., Guo, M.Z., Miller, A.D., and Weiss R.S. (2021) Targeting cancer stem cells with differentiation agents as an alternative to genotoxic chemotherapy for the treatment of malignant testicular germ cell tumors. Cancers 13:2045. doi: 10.3390/cancers13092045. Pubmed. 

Holter M.M., Garibay D., Lee S.A., Saikia M., McGavigan A.K., Ngyuen L., Moore E.S., Daugherity E., Cohen P., Kelly K., Weiss R.S., Cummings B.P. (2020) Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice. FASEB Journal. 34(1):1846-1858. Pubmed.

Pereira, C., Smolka, M.B., Weiss, R.S., and Brieño-Enríquez, M.A. (2020) ATR Signaling in Mammalian Meiosis: From Upstream Scaffolds to Downstream Signaling. Environmental and Molecular Mutagenesis. 61:752-766. Pubmed. 

Lyndaker, A.M., Pierpont, T.M., Loehr, A.R., and Weiss, R.S. (2020) A genetically engineered mouse model of malignant testicular germ cell tumors. In: Bagrodia A., Amatruda J. (eds) Testicular Germ Cell Tumors. Methods in Molecular Biology, vol 2195. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0860-9_11. Pubmed. 

Ma, W., Childers, M., Murray, J., Moussavi-Harami,, F., Gong, H., Weiss, R.S., Daggett V., Irving, T., and Regnier, M. (2020) Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2 deoxy-ATP. J. Physiol. 598:5165-5182. Pubmed. 

Abril, Y.L.N., Fernández, I., and Weiss, R.S. (2019) Assessment of SIRT2 inhibitors in mouse models of cancer. Methods in Molecular Biology, Volume on Protein Acetylation. 1983:151-171. Pubmed.

Bloom, J.C., Loehr, A.R., Schimenti, J.C., and Weiss, R.S. (2019) Germline genome protection: implications for gamete quality and germ cell tumorigenesis. Andrology 7:516-526. Pubmed.

Riter, R.N. and Weiss, R.S. (2019) Connecting students with patients and survivors to enhance cancer research training. Cancer Research, 79(16):4011-4014. Pubmed.

Moore E.S., Daugherity E.K., Karambizi D.I., Cummings B.P., Behling-Kelly E., Schaefer D.M.W., Southard T.L., McFadden J.W., Weiss R.S (2019) Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge. Journal of Biological Chemistry, 294(43):15623-15637. Pubmed.

Greene K.S., Lukey M.J., Wang X., Blank B., Druso J.E., Lin M.J., Stalnecker C.A., Zhang C., Abril Y.L.N., Erickson J.W., Wilson K.F., Lin H., Weiss R.S., Cerione R.A. (2019) SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 116(52): 26625-26632. Pubmed.

Fu,Y., Long, M.J.C., Wisitpitthaya, S., Inayat, H., Pierpont, T.M., Elsaid, I.M., Bloom, J.C., Ortega, J., Weiss, R.S. and Aye, Y. (2018) Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3. Nat. Chem. Biol, 14:943-954. Pubmed.

Patel, D.R. and Weiss, R.S. (2018) A tough row to hoe: when replication forks encounter DNA damage. Biochemical Society Transactions 46:1643-1651. PMID: 30514768

Pierpont, T.M., Lyndaker, A.M.§, Anderson, C.M., Jin, Q., Moore, E.S., Roden, J.L., Braxton, A., Bagepalli, L., Kataria, N., Hu, H.Z., Garness, J., Cook, M.S., Capel, B., Schlafer, D.H., Southard, T., and Weiss R.S.§ (2017) Chemotherapy-induced depletion of OCT4-positive cancer stem cells in a mouse model of malignant testicular cancer. Cell Reports 21:1896–1909. (§co-corresponding authors). Pubmed

Apoorva, F., Tian, Y., Pierpont, T.M., Bassen, D., Butcher, J., Weiss, R.S., and Singh, A. (2017) Lymph Node Stiffness Mimicking Hydrogels Regulate Human B Cell Lymphoma Growth and Cell Surface Receptor Expression in a Molecular Subtype-Specific Manner. Journal of Biomedical Materials Research: Part A. 105:1833-1844. Pubmed

Liu, Y., Cussiol, J.R., Dibitetto, D., Sims, J.R., Twayana, S., Weiss, R.S., Freire, R., Marini, F., Pellicioli, A., and Smolka, M.B. (2017) TOPBP1/Dpb11 Plays a Conserved Role in Homologous Recombination DNA Repair Through the Coordinated Recruitment of 53BP1/Rad9 J. Cell Biol. 216:623-639. Pubmed

Bordeleau, F., Mason, B.N., Lollis, E., Mazzola, M.C., Zanotelli, M.R., Somasegar, S., Califano, J.P., Montague, C.R., LaValley, D., Huynh, J., Mencia-Trinchant, N., Abril, Y.L.N., Hassane, D.C., Bonassar, L.J., Butcher, J.T., Weiss, R.S., and Reinhart-King, C.A. (2017) Matrix stiffening promotes a tumor vasculature phenotype. Proceedings of the National Academy of Science USA, 114:492-497. Pubmed

Subbaramaiah, K., Brown, K.A., Zahid, H., Balmus, G., Weiss, R.S., Herbert, B.-S., and Dannenberg, A.J. (2016) Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells. J. Biol. Chem. 291:16011-16023. Pubmed

Wisitpitthaya, S., Zhao,Y., Long, M.J.C., Li, M., Fletcher, E.A., Blessing, W.A., Weiss, R.S., and Aye, Y. (2016) Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition. ACS Chemical Biology, 11:2021-2032. Pubmed

Jing, H., Hu, J., He, B., Abril, Y.L.N., Stupinski, J., Weiser, K., Carbonaro, M., Chiang,Y-L., Southard, T., Giannakakou, P., Weiss, R.S., and Lin, H. (2016) A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity. Cancer Cell 29:297–310. Pubmed

Sadhukhan, S., Liu, X., Ryu, D., Nelson, O.D., Stupinski, J.A., Li,Z., Chen,W., Zhang, S., Weiss, R.S., Locasale, J.W., Auwerx, J., and Lin, H.(2016) Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of heart function. Proceedings of the National Academy of Science USA 113:4320-4325. Pubmed

Balmus G., Lim, P.X., Oswald A., Hume K.R., Cassano A., Pierre J., Hill A., Huang W., August A., Stokol T., Southard T., and Weiss R.S.(2016) HUS1 regulates in vivo responses to genotoxic chemotherapies. Oncogene 35(5):662-669. Pubmed

Bordeleau, F., Califano, J.P., Abril, Y.L.N., Mason, B.N., LaValley, D., Bonassar, L.J., Shin, S.J., Weiss, R.S., and Reinhart-King, C.A. (2015) Tissue stiffness regulates serine/arginine rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors. Proceedings of the National Academy of Science USA 112:8314-8319. Pubmed

Lim, P.X., Patel, D.R., Poisson, K.E., Basuita, M., Tsai, C., Lyndaker, A.M., Hwang, B.-J., Lu, A-L., and Weiss, R.S. (2015) Genome protection by the 911 subunit HUS1 requires clamp formation, DNA contacts, and ATR signaling-independent effector functions. J. Biol. Chem. 290:14826-14840. Pubmed

Aye, Y. Li, M., Long, M.J.C., and Weiss, R.S. (2015) Ribonucleotide Reductase and cancer: biological mechanisms and targeted therapies. Oncogene 34:2011-2021. Pubmed

Okayama, S., Kopelovich, L., Balmus, G., Weiss, R.S., Herbert, B.-S., Dannenberg, A.J., and Subbaramaiah, K. (2014) p53 Regulates Wnt Signaling Via Effects on Aha1 and Hsp90. J. Biol. Chem. 289:6513-6525. Pubmed

Li, M., Jirapatnakul, A., Biancardi, A., Riccio, M.L., Weiss, R.S., and Reeves, A.P. (2013) Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images. PLoS ONE 8(12): e83806. doi:10.1371/journal.pone.0083806. Pubmed

Yu, J., Sadhukhan, S., Noriega, L.G., Moullan, N., He, B., Weiss, R.S., Lin, H., Schoonjans, K., and Auwerx, J. (2013) Metabolic Characterization of a Sirt5 deficient mouse model. Scientific Reports 3:2806. Pubmed

Lyndaker, A.M., Vasileva, A., Wolgemuth, D.J., Weiss, R.S., and Lieberman, H.B. (2013) Clamping down on mammalian meiosis. Cell Cycle 12(19):3135-45 Pubmed

Ouzounov, D.G., Rivera, D.R., Williams, W.O., Stupinski, J.A., Southard, T.L., Hume, K.R., Brown, C.M., Weiss, R.S., Webb, W.W., and Xu, C. (2013) Dual modality imaging of unstained tissues with an endomicroscope with optical zoom capability. Biomedical Optics Express 4:1494–1503. Pubmed

Nowakowski, S.G, Kolwicz, S.C. Jr., Korte, F.S., Luo, C., Robinson-Hamm, J.N., Page, J.L., Brozovich, F.V., Weiss, R.S., Tian, R., Murry, C.E., and Regnier, M. (2013) Transgenic overexpression of Ribonucleotide Reductase improves cardiac performance. Proceedings of the National Academy of Science USA 110:6187-6192. PubMed

Lyndaker, A.M., Lim, P.X., Mleczko, J.M., Diggins, C., Holloway, J.K., Holmes, R.J., Kan, R., Schlafer, D.H., Freire, R., Cohen, P.E., and Weiss, R.S. (2013) Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. PLoS Genet. 9(2): e1003320. doi:10.1371/journal.pgen.1003320. PubMed

Stover, P.J. and Weiss, R.S. (2012) Sensitizing cancer cells: Is it really all about U? Cancer Cell 22:3-4.PubMed

Balmus, G., Zhu, M., Mukherjee, S., Lyndaker, A.M., Hume, K.R., Lee, J., Riccio, M.L., Reeves, A.P., Sutter, N.B., Noden, D.M., Peters, R.M., and Weiss, R.S. (2012) Disease severity in a mouse model of Ataxia Telangiectasia is modulated by the DNA damage checkpoint gene Hus1. Human Molecular Genetics 21:3408–3420 (featured on journal cover shown at right). PubMed

Daugherity, E.K., Balmus, G., Al Saei, A., Moore, E.S., Abi Abdallah, D., Rogers, A.B., Weiss, R.S., and Maurer, K.J. (2012) The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle 11:1918-1928. PubMed

Qi, Q., Huang, W., Bai, Y., Balmus, G., Weiss, R.S. and August, A. (2012) A unique role for ITK in survival of invariant NKT cells associated with the p53 dependent pathway in mice. Journal of Immunology 188:3611-3619. PubMed

Pavlova, I.P., Hume, K.R., Yazinski, S.A., Flanders, J., Southard, T.L., Weiss, R.S. and Webb, W.W. (2012) Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung. Journal of Biomedical Optics 17, 036014 (2012), DOI:10.1117/1.JBO.17.3.036014. PubMed

Jinadasa R.N., Bloom, S.E., Weiss, R.S., and Duhamel, G.E. (2011) Cytolethal Distending Toxin: A conserved bacterial genotoxin that blocks cell cycle progression leading to apoptosis of a broad range of mammalian cell lineages. Microbiology 157: 1851-1875. PubMed

Holloway, J.K., Mohan, S., Balmus, G., Sun, X., Modzelewski, A., Borst, P.L., Freire, R., Weiss, R.S., and Cohen, P.E. (2011) Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genet. 7(6): e1002094. doi:10.1371/journal.pgen.1002094. PubMed

Jinadasa R., Balmus, G., Gerwitz, L., Roden, J., Weiss, R., and Duhamel, G. (2011) Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice. http:// www.jove.com/details.stp?id=2598 doi: 10.3791/2598. J. Vis. Exp. 50. PubMed

Selvaraj, V., Asano, A., Page, J., Nelson, J.L., Kumar, K., Foster, J., Brenna, T., Weiss, R.S. and Travis, A.J. (2010). Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile. Dev. Biol. 348: 177-189. PubMed

Ylikallio, E., Page, J.L., Xu, X., Lampinen, M., Bepler, G., Ide, T., Tyynismaa, H., Weiss, R.S. and Suomalainen, A. (2010). Ribonucleotide Reductase is not limiting for mitochondrial DNA copy number in mice. Nucleic Acids Res. 38: 8208-8218. PubMed

Song, I.Y., Barkley, L.R., Day, T.A., Weiss, R.S., and Vaziri, C. (2010) A novel role for Fanconi Anemia (FA) pathway effector protein FANCD2 in cell cycle progression of untransformed primary human cells. Cell Cycle 9: 2375-2388. PubMed

Pavlova, I.P., Hume, K.R., Yazinski, S.A., Peters, R.M., Weiss, R.S. and Webb, W.W. (2010) Multiphoton microscopy as a diagnostic imaging modality for lung cancer, Proceedings of the Society of Photo-Optical Instrumentation Engineers, Vol. 7569, 756918. PubMed

Yazinski, S.A., Westcott, P.M., Ong, K., Pinkas, J., Peters, R.M., and Weiss, R.S. (2009) Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration. Proceedings of the National Academy of Science USA 106: 21282–21287. PubMed Cornell news release

Selvaraj, V., Asano, A., Buttke, D.E., Sengupta, P., Weiss, R.S., and Travis, A.J. (2009) Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm. J. Cell. Physiol. 218: 522–536.PubMed

Meyerkord, C.L., Takahashi, Y., Araya, R., Takada, N., Weiss, R.S., and Wang, H- G. (2008) Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins. Oncogene 27: 7248–7259.PubMed

Xu, X., Page, J.L., Surtees, J.A., Liu, H., Lagedrost, S., Lu, Y., Bronson, R., Alani, E., Nikitin, A. Yu., and Weiss, R.S. (2008) Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. Cancer Res. 68: 2652-2660. PubMed

Francia, S., Weiss, R.S., and d’Adda di Fagagna, F. (2007) Need telomere maintenance? Call 911. Cell Division 2: 3. PubMed

Levitt, P.S., Zhu, M., Cassano, A., Yazinski, S.A., Liu, H., Darfler, J., Peters, R.M., and Weiss, R.S. (2007) Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. Mol. Cell. Biol. 27: 2189-2201. PubMed

Zhu, M. and Weiss, R.S. (2007) Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol. Biol. Cell 18: 1044-1055. PubMed

Francia, S., Weiss, R.S., Hande, M.P., Freire, R., and d’Adda di Fagagna, F. (2006) Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex. Curr. Biol. 16: 1551-1558. PubMed

Berghorn, K.A., Clark-Campbell, P.A., Han, L., McGrattan, M., Weiss, R.S., and Roberson, M.S. (2006) Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding. J. Biol. Chem. 281: 20357-20367. PubMed

Affar, E.B., Luke, M.P., Gay, F., Calvo, D., Sui, G., Weiss, R.S., Li, E., and Shi, Y. (2006) Targeted ablation of Par-4 reveals a cell-type specific susceptibility to apoptosis-inducing agents. Cancer Res. 66:3456-3462. PubMed

Wang, X., Hu, B., Weiss, R.S., and Wang, Y. (2006) The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of non-homologous end-joining. Oncogene 25: 1980-1983. PubMed

Levitt, P.S., Liu ,H., Manning, C., and Weiss, R.S. (2005) Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene. Genomics 86:212-224. PubMed

Wang, X., Guan, J., Hu, B., Weiss, R.S., Iliakis, G., and Wang, Y. (2004) Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation. Nucleic Acids Res. 32: 767-775. PubMed