The Tumbar Lab of Tissue Stem Cell Biology

 Cornell University

Publications

Link to our full list of publications in Pubmed

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Alk1 acts in non-endothelial VE-cadherin+ perineurial cells to maintain nerve branching during hair homeostasis. (2023) Chovatiya G, Li KN, Li J, Ghuwalewala S and Tumbar T.   Nat Communications 2023 Sep 12; doi.org/10.1038/s41467-023-40761-5 PubMed PMID: 37699906 [Research Article]

Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation. (2023) Li KN, Chovatiya G, Ko DY, Sureshbabu S and Tumbar T.   EMBO J. 2023 Mar 30; doi.org/10.15252/embj.2022112196 PubMed PMID: 36994549 [Research Article]
Binary organization of epidermal basal domains highlights robustness to environmental exposure. (2022) Ghuwalewala S, Lee SA, Jiang K, Baidya J, Chovatiya G, Kaur P, Shalloway D and Tumbar T.   EMBO J. 2022 Aug 10; doi: 10.15252/embj.2021110488 PubMed PMID: 35949182 [Research Article]
Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis. (2021) Li KN, Tumbar T.   EMBO J. 2021 Apr 20; doi: 10.15252/embj.2020107135 PubMed PMID: 33880808 [Review]
High-resolution single-cell transcriptomics reveals heterogeneity of self-renewing hair follicle stem cells. (2021) Chovatiya G, Ghuwalewala S, Walter LD, Cosgrove BD, Tumbar T.   Exp. Dermatol. 2021 Apr 01;30. doi: 10.1111/exd.14262 PubMed PMID: 33319418; PubMed Central PMCID: PMC8016723. [Research Article]
Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis.(2021) Lee SA, Li KN, Tumbar T.   Exp. Dermatol. 2021 Apr 01;30. doi: 10.1111/exd.14251 PubMed PMID: 33278851; PubMed Central PMCID: PMC8016714. [Review]
Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin.(2020) Kang S, Long K, Wang S, Sada A, Tumbar T.   Stem Cell Rep. 2020 Jan 14;14. doi: 10.1016/j.stemcr.2019.11.007 PubMed PMID: 31866458; PubMed Central PMCID: PMC6962642. [Research Article]
Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis.(2019) Li KN, Jain P, He CH, Eun FC, Kang S, Tumbar T.   Elife. 2019 Jul 25;8. doi: 10.7554/eLife.45977. PubMed PMID: 31343406; PubMed Central PMCID: PMC6684267. [Research Article]
Epigenetic control in skin development, homeostasis and injury repair. (2019) Kang S, Chovatiya G, Tumbar T.  Exp Dermatol. 2019 Apr;28(4):453-463. doi: 10.1111/exd.13872. Epub 2019 Feb 12. Review. PubMed PMID: 30624812; PubMed Central PMCID: PMC6488370. [Review]
Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity. (2018) Jain P, Nattakom M, Holowka D, Wang DH, Thomas Brenna J, Ku AT, Nguyen H, Ibrahim SF, Tumbar T. (2018)  Stem Cells.  Oct;36(10):1603-1616. doi: 10.1002/stem.2868. Epub 2018 Jul 29. PubMed PMID: 29938858; PubMed Central PMCID: PMC6202256. [Research Article]

Gata6 promotes hair follicle matrix progenitor cell renewal by genome maintenance of proliferative cells, (2017) Alex B. Wang, Ying V. Zhang, and Tudorita Tumbar , (EMBO, 2017 Jan 4;36(1):61-78. doi: 10.15252/embj.201694572.) [Research Article]

Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells (2017), Lee JH and Tumbar T. Molecular Life, July; 1(1) doi: 10.26600/MolLife.1.1.2.2017 [Research Article]

Slc1a3-CreER as a targeting tool for the K6+ epithelial stem cell niche and its precursors during mouse hair follicle cycle (2017) Aiko Sada*, Prachi Jain*, Sherry Wang, Eva Leung and Tudorita Tumbar, J Invest Dermatol. 2017 Jul;137(7):1569-1571. doi: 10.1016/j.jid.2017.02.974. Epub 2017 Mar 1 [Research Letter] *, equal contribution

Defining the Cellular Lineage Hierarchy in Adult Skin Epidermis (2016), Nat Cell Biol. Sada A, JacobF, Leung E, Wang S, White BS, Shalloway D and Tumbar T  2016 Jun;18(6):619-31. doi: 10.1038/ncb3359. Epub 2016 May 16. [Research Article] Faculty of 1000 (December 5th 2016)

Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis (2016) Jayhun Lee, Sangjo Kang, Karin C Lilja, Keegan J Colletier, Cornelia Johanna Franziska Scheitz, Ying V Zhang, and Tudorita Tumbar  Nat Commun. 2016 Apr 15;7:11278. doi: 10.1038/ncomms11278.  [Research Article]

A 3D Porous Gelatin-Alginate-Based-IPN Acts as an Efficient Promoter of Chondrogenesis from Human Adipose-Derived Stem Cells. (2015) Dinescu S, Galateanu B, Radu E, Hermenean A, Lungu A, Stancu IC, Jianu D, Tumbar T, Costache M. Stem Cells Int.

Stem cells and their niche in homeostasis/regeneration and disease. Yamashita YM, Tumbar T. Mol Biol Cell. 2014 Mar;25(6)736. Epub 2015 May 27

High Runx1 levels promote a reversible, more-differentiated cell state in hair-follicle stem cells during quiescence. Lee SE, Sada A, Zhang M, McDermitt DJ, Lu SY, Kemphues KJ, Tumbar T. Cell Rep. 2014 Feb 13;6(3):499-513.

Knocking off their Sox: lineage-specific repression by Polycomb in epidermal stem cells. Tumbar T. EMBO J. 2013 Jul 17;32(14):1970-1.

Adult hair follicle stem cells do not retain the older DNA strands in vivo during normal tissue homeostasis. Waghmare SK, Tumbar T. Chromosome Res. 2013 May;21(3):203-12.

New insights into the role of Runx1 in epithelial stem cell biology and pathology. Scheitz CJ, Tumbar T. J Cell Biochem. 2013 May;114(5):985-93.

Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo. Lee J, Hoi CS, Lilja KC, White BS, Lee SE, Shalloway D, Tumbar T. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4634-9.

New insights into mechanisms of stem cell daughter fate determination in regenerative tissues. Sada A, Tumbar T. Int Rev Cell Mol Biol. 2013;300:1-50.

Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer. Scheitz CJ, Lee TS, McDermitt DJ, Tumbar T. EMBO J. 2012 Nov 5;31(21):4124-39.

Hairy tale of signaling in hair follicle development and cycling. Lee J, Tumbar T. Semin Cell Dev Biol. 2012 Oct;23(8):906-16.

Ontogeny and Homeostasis of Adult Epithelial Skin Stem Cells. Tumbar T. Stem Cell Rev. 2012 Jan 31.

Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. Osorio KM, Lilja KC, Tumbar T. J Cell Biol. 2011 Apr 4;193(1):235-50.

Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin. Hoi CS, Lee SE, Lu SY, McDermitt DJ, Osorio KM, Piskun CM, Peters RM, Paus R, Tumbar T. Mol Cell Biol. 2010 May;30(10):2518-36.

Stem cell dynamics in mouse hair follicles: a story from cell division counting and single cell lineage tracing. Zhang YV, White BS, Shalloway DI, Tumbar T. Cell Cycle. 2010 Apr 15;9(8):1504-10.

Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Zhang YV, Cheong J, Ciapurin N, McDermitt DJ, Tumbar T. Cell Stem Cell. 2009 Sep 4;5(3):267-78.

Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. Waghmare SK, Bansal R, Lee J, Zhang YV, McDermitt DJ, Tumbar T. EMBO J. 2008 May 7;27(9):1309-20.

Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation. Osorio KM, Lee SE, McDermitt DJ, Waghmare SK, Zhang YV, Woo HN, Tumbar T. Development. 2008 Mar;135(6):1059-68.

Epithelial skin stem cells. Tumbar T. Methods Enzymol. 2006;419:73-99.

Socializing with the neighbors: stem cells and their niche. Fuchs E, Tumbar T, Guasch G. Cell. 2004 Mar 19;116(6):769-78.

Defining the epithelial stem cell niche in skin. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E. Science. 2004 Jan 16;303(5656):359-63.