Article: Purwada, A; Tian, YF; Huang, WS; Rohrbach, KM; Deol, S; August, A; Singh, A; (2016) “Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy”, Advanced Healthcare Materials, 5 (12):1413-1419
Abstract: Soluble antigen-based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose-limiting systemic toxicity. A versatile, immunomodulatory, self-assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials-based safer immunotherapy approaches.
Funding Acknowledgement: National Institutes of Health (NIH) [1R21CA185236-01, AI073955]; National Science Foundation [DMR-1554275]; Careers in Immunology Fellowship from the American Association of Immunology; Sibley School of Mechanical and Aerospace Engineering at Cornell University; Howard Hughes Medical Institute (HHMI) [56006761]; Cornell University
Funding Text: The authors acknowledge partial financial support from the National Institutes of Health (NIH 1R21CA185236-01 (A.S.), AI073955 (AA)), the National Science Foundation (DMR-1554275 (A.S.)), Careers in Immunology Fellowship from the American Association of Immunology (WH), the Sibley School of Mechanical and Aerospace Engineering at Cornell University, the Howard Hughes Medical Institute (HHMI 56006761, A.P.), and Cornell University’s Dean’s excellence fellowship (K.M.R.). The authors acknowledge assistance from Dr. Ivan Keresztes at Cornell NMR facility for the data acquisition and analysis. The authors acknowledge the Cornell University Biotechnology Resource Center (BRC) Imaging Facility and NIH 1S10RR025502 for data collected on the Zeiss LSM 710 Confocal. The authors acknowledge Cornell University Nanobiotechnology Center (NBTC) for access to shared facilities. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.