Welcome to the Tumbar Lab!
We study molecular mechanisms of adult stem cell tissue regeneration and repair using mouse and human skin as model systems. Using genetic and genomic approaches we study both cell intrinsic and niche related mechanisms employed by adult stem cells for cell fate decisions. Cell intrinsic mechanisms include gene expression regulation by epigenetics factors, RNA Pol II Pausing mechanisms, and RNA stability. We also study the cross-talking of adult stem cells to cells in their surrounding environment, such as melanocytes, blood vessels and nerves. Coordinated actions of these cell types ensure proper tissue function during homeostasis and reduce the rate of cancer.
