This study unravels the recurring sequence of changes within the uterine lumen that supports vital functions (sperm transit and development of preimplantation embryonic stages) during the reproductive cycle in female Ruminantia. New systems knowledge uncovered regarding uterine reproductive physiology correlated with early embryogenesis is crucial for setting up in vitro biomimicry and artificial environments for assisted reproduction technologies for a range of mammalian species. Read the full text at DOI: 10.1152/physiolgenomics.00035.2023