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Selvaraj Laboratory

of Integrative Physiology (SLIP)

Publications

Our philosophy on publishing continues to evolve. We avoid for-profit journals that rip off academic libraries and public funds. We also condemn how journal status and impact factor are frivolously used to judge publication quality. Pressure from institutions and funders have produced artificial standards, and too many publications that do not stand up to further study. We restrict our publications to either journals affiliated with scientific societies/non-profits, or open access journals that evaluate technical rigor without subjective editorial considerations of likely impact in the field.

 

2024

Schalich KM, Koganti PP, Castillo JM, Reiff OM, Cheong SH and Selvaraj V. (2024). The uterine secretory cycle: recurring physiology of endometrial outputs that setup the uterine luminal microenvironment. Physiological Genomics. 56(1):74-97. [Full Text]

Sibinga NA, Won ET and Selvaraj V. (2024). Advances in production of house flies as food and animal feed. In: Insects as alternative sources of protein for food and feed. Ed. Adriana Casillas. Burleigh Dodds publishing, Cambridge, UK.

 

2023

Sushi PS, Kuwabara M, Maung EEW, Mother MSBM, Sakamoto K, Selvaraj V, and Asano A. (2023). Arresting calcium-regulated sperm metabolic dynamics enables prolonged fertility in poultry liquid semen storage. Scientific Reports. 13(1):21775. [Full Text]

Sibinga NA, Lee M-T, Buchon N, Johnson EL, Selvaraj V, and Marquis H. (2023). Do antimicrobial peptide levels alter performance of insect-based aquaculture feeds? A study using genetic models of insect immune activation. Journal of Insects as Food and Feed. 9 (7)- Pages: 919 – 934. [Full Text]

 

2022

Koganti PP, Tu LN and Selvaraj V. (2022). Functional metabolite reserves and lipid homeostasis revealed by the MA-10 Leydig cell metabolome. PNAS Nexus. pgac215. [Full Text]

Koganti PP, Zhao AH and Selvaraj V. (2022). Exogenous cholesterol acquisition signaling in LH-responsive MA-10 Leydig cells and in adult mice. Journal of Endocrinology. 254(3):187-199. [Full Text]

Jimenez IA, Stilin AP, Morohaku K, Hussein MH, Koganti PP and Selvaraj V. (2022). Mitochondrial translocator protein (TSPO) deficiency exacerbates pathology in acute experimental ulcerative colitis. Frontiers in Physiology. 13:896951. [Full Text]

 

Pillai VV, Kei TG, Gurung S, Das M, Siqueira LGB, Cheong SH, Hansen PJ and Selvaraj V. (2022). RhoA/ROCK signaling antagonizes bovine trophoblast stem cell self-renewal and regulates preimplantation embryo size and differentiation. Development. 149(7):dev200115. [Full Text]

Research Highlight: Rock inhibition promotes trophoblast proliferation until the cows come home. Development. (2022) 149 (7): e149_e0702. [Full Text]

 

Sibinga NA, Lee M-T, Johnson EL, Selvaraj V and Marquis H. (2022). Longitudinal sampling of the rainbow trout (Oncorhynchus mykiss) microbiome reveals effects of dietary cecropin A and Yersinia ruckeri infection. Frontiers Marine Science. 9:901389. [Full Text]

Schalich KM and Selvaraj V (2022). Contradictions on colostrum IgG levels and Brix values are real and can be explained. Response to letter by Lombard et al. (2022). Journal of Animal Science. 100(4): skac120. [Link][Full Text]

Bishop CV, Selvaraj V, Townson DH, Pate J, and Wiltbank M (2022). History, insights, and future perspectives on studies into luteal function in cattle. Journal of Animal Science. 100(7):skac143. [Full Text]

Schalich KM, LaPierre PA, and Selvaraj V (2022). Geospatial fluid milk processing preferences: Is consumer taste perception the key factor? Dairy. 3(2), 413-421. [Link][Full Text]

 

2021
 
Selvaraj_JBC_October3_cover Pillai VV, Koganti PP, Kei TG, Gurung S, Butler WR and Selvaraj V. (2021). Efficient induction and sustenance of pluripotent stem cells from bovine somatic cells. Biology Open. 10 (10): bio058756. [Full Text]

First Person – Viju Pillai and Prasanthi Koganti [First author interview]

 
 
 
 
 
 

Schalich KM, Reiff OM, Nguyen BT, Mondoza CR and Selvaraj V. (2021). Temporal kinetics of bovine mammary IgG secretion into colostrum and transition milk. Journal of Animal Science. 99(5): skab083. [Full Text][Press Release from The American Society of Animal Science]

 

2020

Koganti PP and Selvaraj V. (2020). Lack of adrenal TSPO/PBR expression in hamsters reinforces correlation to triglyceride metabolism. Journal of Endocrinology. 247:1-10. [Full Text]

Schalich KM, Herren AW and Selvaraj V. (2020). Analysis of differential strategies to enhance detection of low-abundance proteins in the bovine serum proteome. Animal Science Journal. 91(1):e13388. [Full Text]

Selvaraj V, Morohaku K, Koganti PP, Zhang J, He W, Quirk SM, and Stocco DM. (2020). Commentary: Amhr2-cre mediated global TSPO knockout. Frontiers in Endocrinology. doi: 10.3389/fendo.2020.00472. [Full Text]

Singh A, Dashnyam M, Chim B, Escobar TM, Dulcey AE, Hu X, Wilson KM, Koganti PP, Spinner CA, Xu X, Jadhav A, Southall N, Marugan J, Selvaraj V, Lazarevic V, Muljo SA and Ferrer M. (2020). Anxiolytic drug FGIN-1-27 ameliorates autoimmunity by metabolic reprogramming of pathogenic Th17 cells. Scientific reports. 10(1):3766. [Full Text]

 

2019

Pillai VV, Kei TG, Reddy SE, Das M, Abratte C, Cheong SH and Selvaraj V. (2019). Induced pluripotent stem cell generation from bovine somatic cells indicates unmet needs for pluripotency sustenance. Animal Science Journal. 90(9): 1149-60. [Full Text]

Pillai VV, Siqueira LG, Das M, Kei TG, Tu LN, Herren AW, Phinney BS, Cheong SH, Hansen PJ and Selvaraj V. (2019). Physiological profile of undifferentiated bovine blastocyst-derived trophoblasts. Biology Open. 8, bio037937. [Full Text]

Selvaraj V and Boisclair YR. (2019). Letter to the Editor: About glucose and early embryo development in cows described by Leane et al. (2018). Journal of Dairy Science. 102:2825. https://doi.org/10.3168/jds.2018-15978. [Full Text]

 

2018

Selvaraj V, Stocco DM and Clark BJ. (2018). Current Knowledge on the Acute Regulation of Steroidogenesis. Biology of Reproduction. 99(1):13-26 doi: 10.1093/biolre/ioy102. [Full Text]

Selvaraj V and Koganti PP. (2018). Eat, drink and be merry: Leydig cell autophagy in testosterone production. Biology of Reproduction. 99(6):1113-1115. doi: 10.1093/biolre/ioy153. [Full Text]

Selvaraj V and Stocco DM. (2018). Letter to the Editor: Dubious Conclusions on TSPO Function. Endocrinology. 159(7):2528-2529. doi: 10.1210/en.2018-00052. [Full Text]

 

2017

Pillai VV, Weber DM, Phinney BS, and Selvaraj V. (2017). Profiling of proteins secreted in the bovine oviduct reveals diverse functions of this luminal microenvironment. PLoS ONE. 12(11): e0188105. [Full Text]

Tu LN, Showalter MR, Cajka T, Fan S, Pillai VV, Fiehn O, and Selvaraj V. (2017). Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice. Scientific Reports. 7(1):6120. [Full Text]

Stocco DM, and Selvaraj V. (2017). Yet Another Scenario in the Regulation of the Steroidogenic Acute Regulatory (STAR) Protein Gene. Endocrinology. 158(2):235-238. [Full Text]

Migone FF, Hung PH, Cowan RG, Selvaraj V, Suarez S, Quirk SM. (2017). Overactivation of Hedgehog Signaling Interferes with Regression of the Müllerian Duct. Reproduction. 153(4):481-492.[Pubmed]

Stocco DM, Zhao AH, Tu LN, Morohaku K and Selvaraj V. (2017). A brief history of the search of protein(s) involved in the acute regulation of steroidogenesis. Molecular and Cellular Endocrinology. 441:7-16.[Pubmed]

Hussein M, Pillai VV, Goddard JM, Park HG, Kothapalli KS, Ross DA, Ketterings QM, Brenna JT, Milstein MB, Marquis H, Johnson PA, Nyrop JP and Selvaraj V. (2017). Sustainable production of housefly (Musca domestica) larvae as a protein-rich feed ingredient by utilizing cattle manure. PLoS ONE. 12(2): e0171708. [Full Text]

 

2016

Selvaraj V, Tu LN and Stocco DM. (2016). Crucial role reported for TSPO in viability and steroidogenesis is a misconception. Frontiers in Endocrinology. 7:91.[Full Text]

Selvaraj V and Tu LN. (2016). Current status and future perspectives: TSPO in steroid neuroendocrinology. Journal of Endocrinology. 231(1):R1-R30.[Pubmed]

Mirzaei N, Tang SP, Ashworth S, Coello C, Plisson C, Passchier J, Selvaraj V, Tyacke RJ, Nutt DJ, Sastre M. (2016). In vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer’s disease. Glia. 64(6):993-1006.[Pubmed]

Tu LN, Zhao AH, Hussein M, Stocco DM and Selvaraj V. (2016). Translocator protein (TSPO) affects mitochondrial fatty acid oxidation in steroidogenic cells. Endocrinology. 157(3):1110-21.[Pubmed]

Zhao AH, Tu LN, Mukai C, Sirivelu MP, Pillai VV, Morohaku K, Cohen R and Selvaraj V. (2016). Mitochondrial translocator protein (TSPO) function is not essential for heme biosynthesis. Journal of Biological Chemistry. 291(4):1591-603.[Pubmed]

 

2015

Chung CH, Biswas S, Selvaraj V, Liu X-B, Sohn J, Jiang P, Chen C, Chmilewsky F, Marzban H, Horiuchi M, Pleasure DE and Deng W. (2015). The p38alpha mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS. Cell Death and Disease. 6:e1748.[Pubmed]

Selvaraj V and Stocco DM. (2015). The changing landscape in translocator protein (TSPO) function. Trends in Endocrinology and Metabolism. 26(7):341-8.[Pubmed]

Selvaraj V, Stocco DM and Tu LN. (2015). Translocator protein and steroidogenesis: a reappraisal. Molecular Endocrinology. 29(4):490-501.[Pubmed]

Tu LN, Zhao AH, Stocco DM and Selvaraj V. (2015). PK11195 effect on steroidogenesis is not mediated through the translocator protein (TSPO). Endocrinology. 156(3):1033-9. [Pubmed]

 

2014

Lo U, Selvaraj V, Plane JM, Chechneva OV, Otsu K, Deng W. (2014). p38alpha (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. Scientific Reports. 4:7405. [Pubmed]

 

Selvaraj_JBC_October3_coverTu LN, Morohaku K, Manna PR, Pelton SH, Butler WR, Stocco DM and Selvaraj V. (2014). Peripheral benzodiazepine receptor/translocator protein global knockout mice are viable with no effects on steroid hormone biosynthesis. Journal of Biological Chemistry. 289(40):27444-54. [PubMed] [Press Release from The American Society of Biochemistry and Molecular Biology] [Feature: Lan Tu] [News]

 
 
 
 
 

Morohaku K, Pelton SH, Daugherty DJ, Butler RW, Deng W and Selvaraj V. (2014). Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology. 155(1):89-97. [PubMed] [Press Release from The Endocrine Society] [Commentary] [Counterpoint and response] [News]

 
 
 
 
 
 
 

2013

Morohaku K, Phuong NS and Selvaraj V. (2013). Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues. PLoS One. 8(9):e74509. [PubMed]

Jiang P, Chen C, Liu XB, Selvaraj V, Liu W, Feldman DH, Liu Y, Pleasure DE, Li RA and Deng W. (2013) Generation and characterization of spiking and non-spiking oligodendroglial progenitor cells from embryonic stem cells. Stem Cells. doi: 10.1002/stem.1515. [PubMed]

Daugherty DJ, Selvaraj V , Chechneva OV, Liu XB, Gillardin J-M, Pleasure DE and Deng W. (2013). A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Molecular Medicine. 5(6):891-903. [PubMed]

 

2012

Selvaraj V, Jiang P, Chechneva O, Lo UG and Deng, W. (2012). Differentiating human stem cells into neurons and glial cells for neural repair. Frontiers in Biosciences. (Landmark Edition). 17:65-89. [PubMed]

Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Guo F, Horiuchi M, Zarbalis K, Itoh T, Deng W, and Pleasure DE. (2012). PEDF is a novel oligodendrogenic morphogen acting on adult SVZ and corpus callosum. Journal of Neuroscience. 32(35):12152-64. [PubMed]

Selvaraj V. (2012). Biomedical Applications of Induced Pluripotent Stem Cells. In: Stem Cells and Cancer Stem Cells, Vol 3. Edited by Hayat MA. Springer-Verlag, Germany. pp 265-275. [Full Text]

Williams AJ and Selvaraj V. (2012). iPS cells: born-again stem cells for biomedical applications. In: Biomedical Engineering. Edited by Ghista DN. Intech, Croatia. DOI: 10.5772/19440. [Full Text]

 

2011

Selvaraj V, Wildt DE, Pukazhenthi BS. (2011). Induced pluripotent stem cells for conserving endangered species? Nature Methods. 29;8(10):805-7. [PubMed]

Soundarapandian M, Selvaraj V , Lo U, Golub M, Feldman D, Pleasure DE and Deng W. (2011). Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. Scientific Reports. 1:2 doi:10.1038/srep2. [PubMed]

Shanmugam AS, Jadav KK, Illayaraja S and Selvaraj V. (2011). Effects of body weight and season on serum lipid concentrations in sloth bears (Melursus ursinus ursinus). Journal of Zoo and Wildlife Medicine.  42(3): 373-381. [PubMed]

—————- Previous publications from Vet-Grad-Postdoc ——————-

2010

Jiang P, Selvaraj V  and Deng W. (2010). Differentiation of embryonic stem cells into oligodendrocyte precursors. Journal of Visualized Experiments.  (39). pii: 1960. [PubMed]

Selvaraj V, Plane JM, Williams AJ and Deng W. (2010). Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies. Trends in Biotechnology. 28(4):214-23. [PubMed]

Selvaraj V, Asano A, Page J, Kumar K, Foster J, Nelson JL, Brenna T, Weiss RS and Travis AJ (2010). Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile. Developmental Biology. 15;348(2):177-89. [PubMed]

 

2009

Selvaraj V, Soundarapandian M, Williams AJ, Sidorov MK, Soulika A, Pleasure DE and Deng W. (2009). PARP-1 deficiency increases the severity of disease in a mouse model for multiple sclerosis. Journal of Biological Chemistry. 284(38):26070-84. [PubMed]

Selvaraj V, Asano A, Sengupta P, Weiss RS and Travis AJ. (2009). Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm. Journal of Cellular Physiology. 218(3): 522-36. [PubMed]

Asano A, Selvaraj V, Buttke DE, Nelson JL, Green KM, Evans JE and Travis AJ. (2009). Biochemical characterization of membrane fractions in murine sperm: Identification of three distinct sub-types of membrane rafts. Journal of Cellular Physiology. 218(3): 537-48. [PubMed]

 

2008

Shanmugam AS, Jadav KK, Illayaraja S and Selvaraj V. (2008). Hematology of sloth bears (Melursus ursinus ursinus) from two locations in India. Journal of Wildlife Diseases. 44(2): 509-18. [PubMed]

Shanmugam AS and Selvaraj V. (2008). Development and status of assisted reproductive technologies for the conservation of threatened and endangered species. Proceedings of the Indian Society for the Study of Animal Reproduction.

 

2007

Kim Y, Selvaraj V and Travis AJ. (2007). Effect of donor age on success of spermatogenesis in feline testis xenografts. Reproduction, Fertility and Development. 19(7): 869-876. [PubMed]

Selvaraj V*, Buttke DE*, Asano A, McElwee JL, Wolff CA, Nelson JL, Klaus AV, Hunnicutt GR and Travis AJ. (2007). GM1 dynamics as a marker for membrane changes associated with the process of capacitation in murine and bovine spermatozoa. Journal of Andrology. 28(4): 588-599. *Equal contributors. [PubMed]

 

2006

Selvaraj V*, Asano A*, Buttke DE, McElwee JL, Nelson JL, Wolff CA, Merdiushev T, Fornes MW, Cohen AW, Lisanti MP, Rothblat GH, Kopf GS and Travis AJ. (2006). Segregation of micron-scale membrane sub-domains in live murine sperm. Journal of Cellular Physiology. 206(3): 636-646. *Equal contributors. [PubMed]

Kim Y, Selvaraj V, Dobrinski I, Lee H, McEntee MC and Travis AJ. (2006) Recipient preparation and mixed germ cell isolation for spermatogonial stem cell transplantation in domestic cats. Journal of Andrology. 27(2): 248-256. [PubMed]

Cooke PS, Selvaraj V and Yellayi S. (2006). Genistein, estrogen receptors and the acquired immune response. The Journal of Nutrition. 136(3):704-8. [PubMed]

 

2005

Selvaraj V, Bunick D, Johnson RW, Liu L, Hwang H and Cooke PS. (2005). Gene expression profiling of 17b-estradiol and genistein effects on the mouse thymus. Toxicological Sciences. 87(1): 97-112. [PubMed]

Cooke PS, Selvaraj V, Yellayi S (2005) [Phytoestrogen effects on immunity.] In: Endocrine Disruptors in Life Science-Molecular Mechanism of Health Effects. T Iguchi and T Inoue (eds.), Springer-Verlag, Japan, Ltd., Tokyo, Japan, pp. 255-261.

 

2004

Selvaraj V, Zakroczymski MA, Naaz A, Mukai M, Helferich WG, Doerge DR and Cooke PS. (2004). Estrogenicity of equol on reproductive and non-reproductive organs in mice. Biology of Reproduction. 71(3): 966-972. [PubMed]

 

2003

Yellayi S, Zakroczymski MA, Selvaraj V, Valli EV, Ghanta V, Helfrich WG and Cooke PS. (2003). The phytoestrogen genistein suppresses cell-mediated immunity in mice. Journal of Endocrinology. 176(2): 267-274. [PubMed]

Thilagar S, Ramani C., Ameerjan K and Selvaraj V. (2003) Surgical management of an unusual linear foreign body in a dog. Indian Veterinary Journal. 80: 272-274.

 

2002

Selvaraj V, Kumar RT, Nathan SR, Meenakshisundaram S and Gajendran K. (2002). Prediction of body weight from body measurements in Madras Red Sheep. Indian Journal of Animal Science. 72(2): 180-181.

Shanmugam M, Kumaran RS, Selvaraj V, Manoharan M, Balasubramanyam D. (2002). Knowledge level of dairy breeding practices among farmers in Chengalpattu district. Indian Veterinary Journal. 79(8): 814-816.

 

2001

Selvaraj V, Ariharathirurajkumar H and Bhuvanakumar CK. (2001). Semi-quantitative sweat test in the diagnosis of equine anhidrosis. Indian Veterinary Journal. 78: 790-792.

Shanmugam M, Selvaraj V and Manoharan M. (2001). Management of rectal prolapse in the donkey – a case report. Indian Veterinary Journal. 78: 1043-1044.

Selvaraj V, Samuel J and Nagarajan B. (2001). Clinical assessment of tetanus in a horse. Indian Veterinary Journal. 78: 931-933.

 

2000

Kumar SSS, Selvaraj V and John MC. (2000). Bacteriological examination of water for fecal contamination by presumptive coliform count. Indian Journal of Environment and Ecoplanning. 3(1): 41-44.

Selvaraj V, Ariharathirurajkumar H and Bhuvanakumar CK. (2000). Anhidrosis in thoroughbreds: histopathology of skin. Centaur. 16(4): 83-85.

 

1998

Aiyasami SS, Selvaraj V and John MC. (1998). Observations of Cormorant (Phalacrocorax niger) population in relation to temperature and relative humidity in a pond. Bio-Science Research Bulletin. 14(2): 65-69.

Selvaraj V, Aiyasami SS, Hariprakash B, Rathinam T and John MC. (1998). Tamarind (Tamarindus indica), the ideal nesting substrate for water birds? Proceedings of the Second Pan Commonwealth Veterinary Conference. Pp 765-767.

Selvaraj V, Perumal C and Selvaraj AM. (1998). Pesticide toxicology: a wildlife perspective. Indian Journal of Environment and Ecoplanning. 1(3):23-26.

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