In Fall of 2025 the Cornell Virology Journal Club will meet in person on Fridays from 9:00 to ~10:00 in Lecture Room 7 in College of Veterinary Medicine. You can access this room from the ground-floor atrium.

Information is sent via the Cornell Virology email list (to join see here). We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative. For more information contact Sarah Caddy (sarahcaddy@cornell.edu), Rafael Kroon Campos (rkc73@cornell.edu) or Colin Parrish (crp3@cornell.edu).

The earlier Journal Club Archive Pages can be accessed through this link.

Will Wang from Vanderbilt University in Nashville gives us the background to his paper on the structure of the particles of the Ebola and Marburg viruses (February 7, 2025).

Fall Semester 2025

October 24, Rachel Dufour. Ma Z, Guo L, Ji R, Sun Z, Wang J, Yan Y, Liu K, Zhang H, Wang X, Wu C, Lian L, Cao W, Bai J, Jiang P, Liu X. Pseudorabies virus induces ferroptosis by disrupting iron homeostasis through activation of TfR1 and ferritinophagy. J Virol. 2025 Sep 23;99(9):e0097425. doi: 10.1128/jvi.00974-25. Epub 2025 Sep 2. PMID: 40891826; PMCID: PMC12456129. You can access the paper through the link here.

October 17, Bailey Lubinski. Gasque SN, Han Y, van der Ham I, van Leeuwen D, van Oers MM, Haverkamp A, Ros VID. Baculovirus entry into the central nervous system of Spodoptera exigua caterpillars is independent of the viral protein tyrosine phosphatase. Open Biol. 2024 Feb;14(2):230278. doi: 10.1098/rsob.230278. Epub 2024 Feb 21. PMID: 38378139; PMCID: PMC10878822. You can access the paper through the link here.

October 3, Andrian Gajigan. Gajigan AP, Schvarcz CR, Laughlin AB, Weatherby TM, Culley AI, Edwards KF, Steward GF. A dinoflagellate-infecting giant virus with a micron-length tail. bioRxiv [Preprint]. 2025 Jul 19:2025.07.19.665647. doi: 10.1101/2025.07.19.665647. PMID: 40791400; PMCID: PMC12338748. You can access the paper through the link here. 

September 26, Katelyn Raney-Plourde. Cohen AA, Keeffe JR, Rorick AV, Rho S, Fils AP, Manasyan L, Gao H, Gnanapragasam PNP, Funke HH, Randolph TW, Garcea RL, Bjorkman PJ. Single administration of mosaic-8b RBD-nanoparticle vaccine prepared with atomic layer deposition technology elicits broadly neutralizing anti-sarbecovirus responses. bioRxiv [Preprint]. 2025 Jun 18:2025.06.16.660007. doi: 10.1101/2025.06.16.660007. PMID: 40667356; PMCID: PMC12262612. You can access the paper through the link here. 

September 19, Julie Sahler (Director of the Flow Cytometry Facility). Flow Cytometry: Unlocking Single-Cell Insights in Virology. You can access more information through the link here and here. 

September 12, Ana Alice Pimenta. Hall DR, Johnson RM, Kwon H, Ferdous Z, Laredo-Tiscareño SV, Blitvich BJ, Brackney DE, Smith RC. Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti. Nat Commun. 2025 Jul 1;16(1):5891. doi: 10.1038/s41467-025-61139-9. PMID: 40593674; PMCID: PMC12214649. You can access the paper through the link here. 

September 5, Tawny Chandler.  Kastner AL, Marx AF, Dimitrova M, Abreu-Mota T, Ertuna YI, Bonilla WV, Stauffer K, Künzli M, Wagner I, Kreutzfeldt M, Merkler D, Pinschewer DD. Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection. Immunity. 2025 Feb 11;58(2):481-498.e10. doi: 10.1016/j.immuni.2024.11.021. Epub 2024 Dec 23. PMID: 39719711. You can access the paper through the link here.

Spring Semester 2025

May 2, Tawny Chandler. Kotaki T, Kanai Y, Onishi M, Minami S, Chen Z, Nouda R, Nurdin JA, Yamasaki M, Kobayashi T. Generation of single-round infectious rotavirus with a mutation in the intermediate capsid protein VP6. J Virol. 2024 Jul 23;98(7):e0076224. doi: 10.1128/jvi.00762-24. Epub 2024 Jun 5. PMID: 38837379; PMCID: PMC11265344. You can access the paper through the link here.

April 25, Sarah Saddoris. Cottet L, Cortez-San Martin M, Tello M, Olivares E, Rivas-Aravena A, Vallejos E, Sandino AM, Spencer E. Bioinformatic analysis of the genome of infectious salmon anemia virus associated with outbreaks with high mortality in Chile. J Virol. 2010 Nov;84(22):11916-28. doi: 10.1128/JVI.01202-10. Epub 2010 Sep 1. PMID: 20810724. Also: Markussen T, Jonassen CM, Numanovic S, Braaen S, Hjortaas M, Nilsen H, Mjaaland S. Evolutionary mechanisms involved in the virulence of infectious salmon anaemia virus (ISAV), a piscine orthomyxovirus. Virology. 2008 May 10;374(2):515-27. doi: 10.1016/j.virol.2008.01.019. Epub 2008 Feb 20. PMID: 18280528.
PMC2977892. To access the papers link here and here.

April 18, Bailey Lubinski. Tamanash Bhattacharya, Eva M. Alleman, Alexander C. Noyola, Michael Emerman, Harmit S. Malik A conserved opal termination codon optimizes a temperature-dependent tradeoff between protein production and processing in alphaviruses. bioRxiv 2024.08.21.609082; doi: https://doi.org/10.1101/2024.08.21.609082 You can link directly to the paper here.

April 11, David Buchholz. Mahmoud Bayoumi, Ramya S. Barre, Ruby A. Escobedo, Vinay Shivanna, Nathaniel Jackson, Chengjin Ye, Adolfo García-Sastre, Ahmed Mostafa, Luis Martinez-Sobrido. Identification of Amino Acid Residues Responsible for Differential Replication and Pathogenicity of Avian Influenza Virus H5N1 Isolated from Human and Cattle in Texas, US bioRxiv 2025.03.01.640810; You can find the paper here.

March 21, Sam Campos (seminar speaker). Calton CM, Bronnimann MP, Manson AR, Li S, Chapman JA, Suarez-Berumen M, Williamson TR, Molugu SK, Bernal RA, Campos SK. Translocation of the papillomavirus L2/vDNA complex across the limiting membrane requires the onset of mitosis. PLoS Pathog. 2017 May 2;13(5):e1006200. doi: 10.1371/journal.ppat.1006200. PMID: 28463988; PMCID: PMC5412990. You can access the paper here.
(He will also refer to this paper that he collaborated on: Aydin I, Villalonga-Planells R, Greune L, Bronnimann MP, Calton CM, Becker M, Lai KY, Campos SK, Schmidt MA, Schelhaas M. A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry. PLoS Pathog. 2017 May 2;13(5):e1006308. doi: 10.1371/journal.ppat.1006308. PMID: 28464022; PMCID: PMC5412989. You can access this paper here.)

March 14, Colin Parrish. Ishemgulova A, Mukhamedova L, Trebichalská Z, Rájecká V, Payne P, Šmerdová L, Moravcová J, Hrebík D, Buchta D, Škubník K, Füzik T, Vaňáčová Š, Nováček J, Plevka P. Endosome rupture enables enteroviruses from the family Picornaviridae to infect cells. Commun Biol. 2024 Nov 8;7(1):1465. doi: 10.1038/s42003-024-07147-9. PMID: 39511383; PMCID: PMC11543853. You can access the manuscript through this link.

March 7, Laura Dunn. Hyde VR, Zhou C, Fernandez JR, Chatterjee K, Ramakrishna P, Lin A, Fisher GW, Çeliker OT, Caldwell J, Bender O, Sauer PJ, Lugo-Martinez J, Bar DZ, D’Aiuto L, Shemesh OA. Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s disease. Cell Rep. 2025 Jan 28;44(1):115109. doi: 10.1016/j.celrep.2024.115109. Epub 2025 Jan 2. PMID: 39753133. You can link more directly through this link.

February 28, Camille Holmes. Verhoeven D, Sponseller BA, Crowe JE Jr, Bangaru S, Webby RJ, Lee BM. Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen. NPJ Vaccines. 2024 Dec 19;9(1):247. doi: 10.1038/s41541-024-01037-1. PMID: 39702334; PMCID: PMC11659547. You can access the paper through this link.

February 21, Sarah Caddy. Sherry L, Bahar MW, Porta C, Fox H, Grehan K, Nasta V, Duyvesteyn HME, De Colibus L, Marsian J, Murdoch I, Ponndorf D, Kim SR, Shah S, Carlyle S, Swanson JJ, Matthews S, Nicol C, Lomonossoff GP, Macadam AJ, Fry EE, Stuart DI, Stonehouse NJ, Rowlands DJ. Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines. Nat Commun. 2025 Jan 18;16(1):831. doi: 10.1038/s41467-025-56118-z. PMID: 39827284; PMCID: PMC11742952. You can access the paper directly though this link.

February 14, Rowena Bull (seminar speaker). Young C, Singh M, Jackson KJL, Field MA, Peters TJ, Angioletti-Uberti S, Frenkel D, Ravishankar S, Gupta M, Wang JJ, Agapiou D, Faulks ML, Al-Eryani G, Luciani F, Gordon TP, Reed JH, Danta M, Carr A, Kelleher AD, Dore GJ, Matthews G, Brink R, Bull RA, Suan D, Goodnow CC. A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease. Immunity. 2025 Jan 9:S1074-7613(24)00575-2. doi: 10.1016/j.immuni.2024.12.011. Epub ahead of print. PMID: 39818208. You can connect to the reference here.

February 7, Will Wan (seminar speaker). Wan W, Kolesnikova L, Clarke M, Koehler A, Noda T, Becker S, Briggs JAG. Structure and assembly of the Ebola virus nucleocapsid. Nature. 2017 Nov 16;551(7680):394-397. doi: 10.1038/nature24490. Epub 2017 Nov 8. PMID: 29144446; PMCID: PMC5714281. You can link to that paper directly here.

January 31, Solomiia Khomandiak. Sun C, Kang YF, Fang XY, Liu YN, Bu GL, Wang AJ, Li Y, Zhu QY, Zhang H, Xie C, Kong XW, Peng YJ, Lin WJ, Zhou L, Chen XC, Lu ZZ, Xu HQ, Hong DC, Zhang X, Zhong L, Feng GK, Zeng YX, Xu M, Zhong Q, Liu Z, Zeng MS. A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV. Cell Host Microbe. 2023 Nov 8;31(11):1882-1897.e10. doi: 10.1016/j.chom.2023.09.011. Epub 2023 Oct 16. PMID: 37848029. You can link to the article directly here.

Earlier Journal Club Archive Pages can be accessed through this link.