In Fall of 2024 the Cornell Virology Journal Club will meet in person on Fridays from 9:00 to ~10:00 in Lecture Room 7 in College of Veterinary Medicine (apart from November 29 – Thanksgiving). You can access this room from the ground-floor atrium.
Information is sent via the Cornell Virology email list (to join see here). We discuss papers that have been published recently, historical papers, or people can present research findings or new methods. Feel free to be creative. For more information contact Colin Parrish (crp3).
Siyuan Ding from Washington University in St Louis gives us the background to his paper on the TMPRSS enzymes and SARS CoV-2 activation (March 2023).
Fall Semester 2024
November 15, Meleana Hinchman. McNamara AJ, Brooks AD, Danthi P. The Reovirus σ3 Protein Inhibits NF-κB-Dependent Antiviral Signaling. J Virol. 2022 May 11;96(9):e0051522. doi: 10.1128/jvi.00515-22. Epub 2022 Apr 13. PMID: 35416720; PMCID: PMC9093121. You can access the reference here.
November 8, Margaret Ackerman. Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA. Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. Sci Transl Med. 2019 Apr 10;11(487):eaau6039. doi: 10.1126/scitranslmed.aau6039. PMID: 30971454; PMCID: PMC6681804. You can access the reference here.
November 1, Claire Birkenheuer. Policastro PF, Schneider CA, Winkler CW, Leung JM, Peterson KE. Retinoic acid-induced differentiation and oxidative stress inhibitors increase resistance of human neuroblastoma cells to La Crosse virus-induced cell death. J Virol. 2024 Oct 9:e0030024. doi: 10.1128/jvi.00300-24. Epub ahead of print. PMID: 39382324. You can access the reference here.
October 25, Viraj Upadhye. Mangala Prasad V, Leaman DP, Lovendahl KN, Croft JT, Benhaim MA, Hodge EA, Zwick MB, Lee KK. Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice. Cell. 2022 Feb 17;185(4):641-653.e17. doi: 10.1016/j.cell.2022.01.013. Epub 2022 Feb 4. PMID: 35123651; PMCID: PMC9000915. You can access the reference here.
October 11, Steven Moran. Aquino ILM, Reis ES, Moreira ROAM, Arias NEC, Barcelos MG, Queiroz VF, Arifa RDdN, Lucas LMB, Tatara JM, Souza DG, Costa A, Rosa L, Almeida GMF, Kroon EG, Abrahão JS. Giant viruses inhibit superinfection by downregulating phagocytosis in Acanthamoeba. J Virol. 2024 Sep 3:e0104524. doi: 10.1128/jvi.01045-24. Epub ahead of print. PMID: 39225468. You can access the reference here.
October 4, Colin Parrish. Trovão NS, Khan SM, Lemey P, Nelson MI, Cherry JL. Comparative evolution of influenza A virus H1 and H3 head and stalk domains across host species. mBio. 2024 Jan 16;15(1):e0264923. doi: 10.1128/mbio.02649-23. Epub 2023 Dec 11. PMID: 38078770; PMCID: PMC10886446. You can access the reference here.
September 27, Louise Moncla (Seminar Speaker), University of Pennsylvania. Reference she will discuss the bacground to: Moncla LH, Black A, DeBolt C, Lang M, Graff NR, Pérez-Osorio AC, Müller NF, Haselow D, Lindquist S, Bedford T. Repeated introductions and intensive community transmission fueled a mumps virus outbreak in Washington State. Elife. 2021 Apr 19;10:e66448. doi: 10.7554/eLife.66448. PMID: 33871357; PMCID: PMC8079146. You can access the reference here.
September 20. Sarah Saddoris and Alexis Smrekar. Walter RM, Majumder K, Kalejta RF. ATRX restricts Human Cytomegalovirus (HCMV) viral DNA replication through heterochromatinization and minimizes unpackaged viral genomes. PLoS Pathog. 2024 Sep 5;20(9):e1012516. doi: 10.1371/journal.ppat.1012516. Epub ahead of print. PMID: 39236084. To access the manuscript please go here.
September 13. Bailey Lubinski. Zhou X, Singh M, Sanz Santos G, Guerlavais V, Carvajal LA, Aivado M, Zhan Y, Oliveira MMS, Westerberg LS, Annis DA, Johnsen JI, Selivanova G. Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity. Cancer Discov. 2021 Dec 1;11(12):3090-3105. doi: 10.1158/2159-8290.CD-20-1741. PMID: 34230007; PMCID: PMC9414294. To access the manuscript please go here.
September 6. Laura Dunn. Vakaniaki EH, Kacita C, Kinganda-Lusamaki E, O’Toole Á, Wawina-Bokalanga T, Mukadi-Bamuleka D, Amuri-Aziza A, Malyamungu-Bubala N, Mweshi-Kumbana F, Mutimbwa-Mambo L, Belesi-Siangoli F, Mujula Y, Parker E, Muswamba-Kayembe PC, Nundu SS, Lushima RS, Makangara-Cigolo JC, Mulopo-Mukanya N, Pukuta-Simbu E, Akil-Bandali P, Kavunga H, Abdramane O, Brosius I, Bangwen E, Vercauteren K, Sam-Agudu NA, Mills EJ, Tshiani-Mbaya O, Hoff NA, Rimoin AW, Hensley LE, Kindrachuk J, Baxter C, de Oliveira T, Ayouba A, Peeters M, Delaporte E, Ahuka-Mundeke S, Mohr EL, Sullivan NJ, Muyembe-Tamfum JJ, Nachega JB, Rambaut A, Liesenborghs L, Mbala-Kingebeni P. Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo. Nat Med. 2024 Jun 13. doi: 10.1038/s41591-024-03130-3. Epub ahead of print. PMID: 38871006. To access the manuscript directly please go here.
Summer Special Sessions.
June 14th, ASV Practice talks – 9am in the Centennial Room.
Spring Semester 2024
May 10th, James Crowe (Seminar Speaker): Will discuss a recent publication from his laboratory. (Last journal club of the semester).
May 3rd, David Buchholz: Burrough ER, Magstadt DR, Petersen B, Timmermans SJ, Gauger PC, Zhang J, Siepker C, Mainenti M, Li G, Thompson AC, Gorden PJ, Plummer PJ, Main R. Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Domestic Dairy Cattle and Cats, United States, 2024. Emerg Infect Dis. 2024 Apr 29;30(7). doi: 10.3201/eid3007.240508. Epub ahead of print. PMID: 38683888. You can access the reference directly here.
April 19th, Oluwafemi (Femi) Adu: Liao Z, Wang C, Tang X, Yang M, Duan Z, Liu L, Lu S, Ma L, Cheng R, Wang G, Liu H, Yang S, Xu J, Tadese DA, Mwangi J, Kamau PM, Zhang Z, Yang L, Liao G, Zhao X, Peng X, Lai R. Human transferrin receptor can mediate SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2317026121. doi: 10.1073/pnas.2317026121. Epub 2024 Feb 26. PMID: 38408250; PMCID: PMC10927525. You can access the reference here.
April 12th, Richard Adeleke: Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M. Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase. Immunity. 2024 Mar 12;57(3):574-586.e7. doi: 10.1016/j.immuni.2024.02.003. Epub 2024 Mar 1. PMID: 38430907; PMCID: PMC10962683. You can access the reference here.
April 5th, Viraj Upadhye: Turoňová B, Sikora M, Schürmann C, Hagen WJH, Welsch S, Blanc FEC, von Bülow S, Gecht M, Bagola K, Hörner C, van Zandbergen G, Landry J, de Azevedo NTD, Mosalaganti S, Schwarz A, Covino R, Mühlebach MD, Hummer G, Krijnse Locker J, Beck M. In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science. 2020 Oct 9;370(6513):203-208. doi: 10.1126/science.abd5223. Epub 2020 Aug 18. PMID: 32817270; PMCID: PMC7665311. You can access the reference here.
March 29th, Scott Biering (Seminar Speaker): Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O’Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. Nat Genet. 2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. Epub 2022 Jul 25. PMID: 35879412; PMCID: PMC9355872. You can access the reference here:
March 15th, Sergei Pond (Seminar Speaker): Kosakovsky Pond SL, Poon AF, Leigh Brown AJ, Frost SD. A maximum likelihood method for detecting directional evolution in protein sequences and its application to influenza A virus. Mol Biol Evol. 2008 Sep;25(9):1809-24. doi: 10.1093/molbev/msn123. Epub 2008 May 29. PMID: 18511426; PMCID: PMC2515872. To access the paper click here.
March 8, Claire Birkenheuer. Jammes M, Golyaev V, Fuentes A, Laboureau N, Urbino C, Plissonneau C, Peterschmitt M, Pooggin MM. Transcriptome and small RNAome profiling uncovers how a recombinant begomovirus evades RDRγ-mediated silencing of viral genes and outcompetes its parental virus in mixed infection. PLoS Pathog. 2024 Jan 12;20(1):e1011941. doi: 10.1371/journal.ppat.1011941. PMID: 38215155; PMCID: PMC10810479. To access the paper click here.
March 1, Brian Wasik. Zhou Y, Routh AL. Bipartite viral RNA genome heterodimerization influences genome packaging and virion thermostability. J Virol. 2024 Feb 8:e0182023. To access the paper click here.
February 23rd, Kristen Ogden (Seminar Speaker): Thoner TW Jr, Meloy MM, Long JM, Diller JR, Slaughter JC, Ogden KM. Reovirus Efficiently Reassorts Genome Segments during Coinfection and Superinfection. J Virol. 2022 Sep 28;96(18):e0091022. doi: 10.1128/jvi.00910-22. Epub 2022 Sep 12. PMID: 36094315; PMCID: PMC9517712. To access the paper click here.
February 16th, Sarah Caddy: Hsieh W-S, Chao C-H, Shen C-Y, Cheng D, Huang S-W, Wang Y-F, Chen C-C, Chen S-H, Hsu L-J, Wang J-R. VP1 codon deoptimization and high-fidelity substitutions in 3D polymerase as potential vaccine strategies for eliciting immune responses against enterovirus A71. J Virol. 2024 Jan 23;98(1):e0155823. doi: 10.1128/jvi.01558-23. Epub 2024 Jan 4. PMID: 38174926; PMCID: PMC10804986. To access the paper click here.
February 9, Sarah Saddoris: Fenwick M, Roizman B. Regulation of herpesvirus macromolecular synthesis. VI. Synthesis and modification of viral polypeptides in enucleated cells. J Virol. 1977 Jun;22(3):720-5. doi: 10.1128/JVI.22.3.720-725.1977. PMID: 195087; PMCID: PMC515771. To access the paper click here.
January 26th, Laura Dunn. Yaara Finkel, Aharon Nachshon, Einav Aharon, Tamar Arazi, Elena Simonovsky, Martina Dobesova, Avi Gluck, Tal Fisher, Richard J. Stanton, Michal Schwartz, Noam Stern-GinossarA virally encoded high resolution screen of cytomegalovirus host dependencies. bioRxiv 2023.10.30.564793; doi: https://doi.org/10.1101/2023.10.30.564793. To access the paper click here.
January 19th, Colin Parrish. Hufnagel DE, Young KM, Arendsee ZW, Gay LC, Caceres CJ, Rajão DS, Perez DR, Vincent Baker AL, Anderson TK. Characterizing a century of genetic diversity and contemporary antigenic diversity of N1 neuraminidase in influenza A virus from North American swine. Virus Evol. 2023 Feb 28;9(1):vead015. doi: 10.1093/ve/vead015. PMID: 36993794; PMCID: PMC10041950. To access the paper click here.
Fall Semester 2023
December 7, Annie Chien. Shi W, Cai Y, Zhu H, Peng H, Voyer J, Rits-Volloch S, Cao H, Mayer ML, Song K, Xu C, Lu J, Zhang J, Chen B. Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane. Nature. 2023 Jul;619(7969):403-409. doi: 10.1038/s41586-023-06273-4. Epub 2023 Jun 7. PMID: 37285872. To access the paper click here.
December 1, Ambika Pachaury. Kumar B, Hawkins GM, Kicmal T, Qing E, Timm E, Gallagher T. Assembly and Entry of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2): Evaluation Using Virus-Like Particles. Cells. 2021 Apr 9;10(4):853. doi: 10.3390/cells10040853. PMID: 33918600; PMCID: PMC8068838. To access the paper click here.
November 17, Scott Hensley (University of Pennsylvania). Bolton MJ, Santos JJS, Arevalo CP, Griesman T, Watson M, Li SH, Bates P, Ramage H, Wilson PC, Hensley SE. IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2216521120. doi: 10.1073/pnas.2216521120. Epub 2023 Aug 21. PMID: 37603748; PMCID: PMC10469028. To access the paper click here.
November 10, Claire Birkenheuer. Anderson ML, Sullivan OM, Nichols SL, Kaylor L, Kelly DF, McDonald Esstman S. Rotavirus core shell protein sites that regulate intra-particle polymerase activity. J Virol. 2023 Oct 13:e0086023. doi: 10.1128/jvi.00860-23. Epub ahead of print. PMID: 37830817. To access the paper click here.
September 29, Sashi (Sasirekha) Ramani – Baylor College of Medicine. Adeniyi-Ipadeola GO, Hankins JD, Kambal A, Zeng XL, Patil K, Poplaski V, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Crawford SE, Blutt SE, Speer AL, Estes MK, Ramani S. Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct. bioRxiv [Preprint]. 2023 May 20:2023.05.19.541350. doi: 10.1101/2023.05.19.541350. PMID: 37292968; PMCID: PMC10245709. To access the paper click here.
September 22, Brian Wasik, brw72. Sun H, Li H, Tong Q, Han Q, Liu J, Yu H, Song H, Qi J, Li J, Yang J, Lan R, Deng G, Chang H, Qu Y, Pu J, Sun Y, Lan Y, Wang D, Shi Y, Liu WJ, Chang KC, Gao GF, Liu J. Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets. Cell. 2023 Sep 14;186(19):4074-4084.e11. doi: 10.1016/j.cell.2023.08.011. Epub 2023 Sep 4. PMID: 37669665. To access the paperclick here.
September 15, Colin Parrish, crp3. Pinto RM, Bakshi S, Lytras S, Zakaria MK, Swingler S, Worrell JC, Herder V, Hargrave KE, Varjak M, Cameron-Ruiz N, Collados Rodriguez M, Varela M, Wickenhagen A, Loney C, Pei Y, Hughes J, Valette E, Turnbull ML, Furnon W, Gu Q, Orr L, Taggart A, Diebold O, Davis C, Boutell C, Grey F, Hutchinson E, Digard P, Monne I, Wootton SK, MacLeod MKL, Wilson SJ, Palmarini M. BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature. 2023 Jul;619(7969):338-347. doi: 10.1038/s41586-023-06261-8. Epub 2023 Jun 28. PMID: 37380775. To access the paper click here.
September 8, Laura Dunn, led97. Ouwendijk WJD, Roychoudhury P, Cunningham AL, Jerome KR, Koelle DM, Kinchington PR, Mohr I, Wilson AC, Verjans GMGM, Depledge DP. Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice. bioRxiv [Preprint]. 2023 Jul 18:2023.07.17.549345. doi: 10.1101/2023.07.17.549345. PMID: 37503290; PMCID: PMC10370134. To access the paper click here.
September 1, Bailey Lubinsky. Yin P, Davenport BJ, Wan JJ, Kim AS, Diamond MS, Ware BC, Tong K, Couderc T, Lecuit M, Lai JR, Morrison TE, Kielian M. Chikungunya virus cell-to-cell transmission is mediated by intercellular extensions in vitro and in vivo. Nat Microbiol. 2023 Aug 17. doi: 10.1038/s41564-023-01449-0. Epub ahead of print. PMID: 37591996. To access the paper click here.
Spring Semester 2023
May 12, Femi Adu. Arevalo CP, Bolton MJ, Le Sage V, Ye N, Furey C, Muramatsu H, Alameh MG, Pardi N, Drapeau EM, Parkhouse K, Garretson T, Morris JS, Moncla LH, Tam YK, Fan SHY, Lakdawala SS, Weissman D, Hensley SE. A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes. Science. 2022 Nov 25;378(6622):899-904. doi: 10.1126/science.abm0271. Epub 2022 Nov 24. PMID: 36423275. Link to the paper here.
April 28, Viraj Upadhye. Shah PNM, Gilchrist JB, Forsberg BO, Burt A, Howe A, Mosalaganti S, Wan W, Radecke J, Chaban Y, Sutton G, Stuart DI, Boyce M. Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography. Cell Host Microbe. 2023 Apr 12;31(4):604-615.e4. doi: 10.1016/j.chom.2023.03.004. Epub 2023 Mar 29. PMID: 36996819. Link to the paper here.
April 13th, Brian Wasik. Diverse and abundant viruses exploit conjugative plasmids.
April 7th, Richard Adeleke. Amanat F, Clark J, Carreño JM, Strohmeier S, Yellin T, Meade PS, Bhavsar D, Muramatsu H, Sun W, Coughlan L, Pardi N, Krammer F. Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination. J Virol. 2023 Mar 30;97(3):e0166422. doi: 10.1128/jvi.01664-22. Epub 2023 Feb 13. PMID: 36779758; PMCID: PMC10062180. Link to the NCBI record here.
March 31, John Parker. Irgen-Gioro S, Yoshida S, Walling V, Chong S. Fixation can change the appearance of phase separation in living cells. Elife. 2022 Nov 29;11:e79903. doi: 10.7554/eLife.79903. PMID: 36444977; PMCID: PMC9817179. Link to the NCBI record here.
March 24, Claire Birkenheuer. This Week In The Hagan Room – S1-214. Arragain B, Durieux Trouilleton Q, Baudin F, Provaznik J, Azevedo N, Cusack S, Schoehn G, Malet H. Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun. 2022 Feb 16;13(1):902. doi: 10.1038/s41467-022-28428-z. PMID: 35173159; PMCID: PMC8850483. Link to the NCBI record here.
March 17, Gary Whittaker. Chen J, Yang X, Si H, Gong Q, Que T, Li J, Li Y, Wu C, Zhang W, Chen Y, Luo Y, Zhu Y, Li B, Luo D, Hu B, Lin H, Jiang R, Jiang T, Li Q, Liu M, Xie S, Su J, Zheng X, Li A, Yao Y, Yang Y, Chen P, Wu A, He M, Lin X, Tong Y, Hu Y, Shi ZL, Zhou P. A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry. Cell. 2023 Feb 16;186(4):850-863.e16. doi: 10.1016/j.cell.2023.01.019. PMID: 36803605; PMCID: PMC9933427. Link to the NCBI record here.
March 10, Siyuan Ding (guest presenter from Washington University in St Louis). Zang R, Gomez Castro MF, McCune BT, Zeng Q, Rothlauf PW, Sonnek NM, Liu Z, Brulois KF, Wang X, Greenberg HB, Diamond MS, Ciorba MA, Whelan SPJ, Ding S. TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes. Sci Immunol. 2020 May 13;5(47):eabc3582. doi: 10.1126/sciimmunol.abc3582. PMID: 32404436; PMCID: PMC7285829. Link to the NCBI record here.
March 3, Rohit Jangra (guest presenter from Lousiana State University). Dieterle ME, Solà-Riera C, Ye C, Goodfellow SM, Mittler E, Kasikci E, Bradfute SB, Klingström J, Jangra RK, Chandran K. Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells. Elife. 2021 Jul 6;10:e69708. doi: 10.7554/eLife.69708. PMID: 34232859; PMCID: PMC8263056. Link to the NBI record here.
February 24, Andrew Broadbent (guest presenter from the University of Maryland). Reddy VRAP, Nazki S, Brodrick AJ, Asfor A, Urbaniec J, Morris Y, Broadbent AJ. Evaluating the Breadth of Neutralizing Antibody Responses Elicited by Infectious Bursal Disease Virus Genogroup A1 Strains Using a Novel Chicken B-Cell Rescue System and Neutralization Assay. J Virol. 2022 Sep 28;96(18):e0125522. doi: 10.1128/jvi.01255-22. Epub 2022 Sep 7. PMID: 36069547; PMCID: PMC9517715. Link to the NCBI record here.
February 17, Mason Jager. Kishimoto M, Kajihara M, Tabata K, Itakura Y, Toba S, Ozono S, Sato Y, Suzuki T, Ito N, Changula K, Qiu Y, Mori-Kajihara A, Eto Y, Harima H, Mwizabi D, Hang’ombe BM, Hall WW, Takada A, Orba Y, Sawa H, Sasaki M. Isolation and Characterization of Distinct Rotavirus A in Bat and Rodent Hosts. J Virol. 2023 Jan 31;97(1):e0145522. doi: 10.1128/jvi.01455-22. Epub 2023 Jan 12. PMID: 36633410; PMCID: PMC9888233. Link to the NCBI record here.
February 10, Clifton Ricaña. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, et al. and Liu GH. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023 Jan 19;186(2):287-304.e26. doi: 10.1016/j.cell.2022.12.017. Epub 2023 Jan 6. PMID: 36610399. Link to the NCBI record here.
February 3, Madeleine Dumas. Skorupka KA, Roganowicz MD, Christensen DE, Wan Y, Pornillos O, Ganser-Pornillos BK. Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids. Sci Adv. 2019 Nov 27;5(11):eaaw3631. doi: 10.1126/sciadv.aaw3631. PMID: 31807695; PMCID: PMC6881174. Link to the NCBI record here.
January 27, Laura Dunn. Naesens L, Muppala S, Acharya D, Nemegeer J, Bogaert D, Lee JH, Staes K, Debacker V, De Bleser P, De Bruyne M, De Baere E, van Gent M, Liu G, Lambrecht BN, Staal J, Kerre T, Beyaert R, Maelfait J, Tavernier SJ, Gack MU, Haerynck F. GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141. Sci Immunol. 2022 Nov 25;7(77):eabq4531. doi: 10.1126/sciimmunol.abq4531. Epub 2022 Nov 18. PMID: 36399538. Link to NCBI here.
January 20, Colin Parrish. Campbell MA, Loncar S, Kotin RM, Gifford RJ. Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates. PLoS Biol. 2022 Nov 29;20(11):e3001867. doi: 10.1371/journal.pbio.3001867. PMID: 36445931; PMCID: PMC9707805. Link to the NCBI record here.
Fall Semester 2022
December 8, Jessie Cunningham.
December 1, Sarah Caddy. Bakkers MJG, Moon-Walker A, Herlo R, Brusic V, Stubbs SH, Hastie KM, Saphire EO, Kirchhausen TL, Whelan SPJ. CD164 is a host factor for lymphocytic choriomeningitis virus entry. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2119676119. doi: 10.1073/pnas.2119676119. Epub 2022 Mar 2. PMID: 35235462; PMCID: PMC8915965.
November 24, Thanksgiving – no meeting.
November 17, Benjamin Kaza. Dechant PP, He YH. Machine-learning a virus assembly fitness landscape. PLoS One. 2021 May 5;16(5):e0250227. doi: 10.1371/journal.pone.0250227. PMID: 33951035; PMCID: PMC8099058.
November 10, Annika Diaz. Zhang C, Yang F, Wojdyla JA, Qin B, Zhang W, Zheng M, Cao W, Wang M, Gao X, Zheng H, Cui S. An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein. Cell Rep. 2022 Jul 5;40(1):111030. doi: 10.1016/j.celrep.2022.111030. PMID: 35793627.
November 3, Claire Birkenheuer. Rowbotham K, Hanson B, Haugen J, Milavetz B. Early in an SV40 infection, histone modifications correlate with the presence or absence of RNAPII and direction of transcription. Virology. 2022 Aug;573:59-71. doi: 10.1016/j.virol.2022.05.009. Epub 2022 Jun 8. PMID: 35717712.
October 27, Jessica Noll. Riera E, Pérez-Núñez D, García-Belmonte R, Miorin L, García-Sastre A, Revilla Y. African Swine Fever Virus Induces STAT1 and STAT2 Degradation to Counteract IFN-I Signaling. Front Microbiol. 2021 Aug 26;12:722952. doi: 10.3389/fmicb.2021.722952.
October 20, Bailey Lubinski.Chen M, Wang MH, Shen XG, Liu H, Zhang YY, Peng JM, Meng F, Wang TY, Bai YZ, Sun MX, Tian ZJ, Yin X, Cai XH, Tang YD. Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner. J Virol. 2022 Sep 29:e0131822. doi: 10.1128/jvi.01318-22.
October 13, Luara Dunn. Ly M, Burgess HM, Shah SB, Mohr I, Glaunsinger BA. Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing. PLoS Pathog. 2022 Feb 24;18(2):e1010099. doi: 10.1371/journal.ppat.1010099.
October 6, 2022. Richard Adeleke. Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Smith BK, Shrihari S, McCune BT, Harvey IB, Keeler SP, Bloyet LM, Zhao H, Ma M, Adams LJ, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ, Diamond MS. Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice. Cell Host Microbe. 2020 Sep 9;28(3):465-474.e4. doi: 10.1016/j.chom.2020.07.018.
September 29, 2022. Carolina Menchaca.Munshi S, Neupane K, Ileperuma SM, Halma MTJ, Kelly JA, Halpern CF, Dinman JD, Loerch S, Woodside MT. Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses. Viruses. 2022 Jan 18;14(2):177. doi: 10.3390/v14020177.
September 22, 2022. Madeleine Dumas. Mangala Prasad V, Blijleven JS, Smit JM, Lee KK. Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery. Nat Commun. 2022 Aug 15;13(1):4772. doi: 10.1038/s41467-022-32431-9.
September 15, 2022. Colin Parrish. Kwon Y, Kaake RM, Echeverria I, Suarez M, Karimian Shamsabadi M, Stoneham C, Ramirez PW, Kress J, Singh R, Sali A, Krogan N, Guatelli J, Jia X. Structural basis of CD4 downregulation by HIV-1 Nef. Nat Struct Mol Biol. 2020 Sep;27(9):822-828. doi: 10.1038/s41594-020-0463-z.
September 8, 2022. Viraj Upadhye. Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, et al. Lanzavecchia A, Kwong PD. Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12265-12270. doi: 10.1073/pnas.1811980115.
September 1, 2022. Sarah Saddoris.Fang A, Yuan Y, Huang F, Wang C, Tian D, Zhou R, Zhou M, Chen H, Fu ZF, Zhao L. Lab-Attenuated Rabies Virus Facilitates Opening of the Blood-Brain Barrier by Inducing Matrix Metallopeptidase 8. J Virol. 2022 Sep 14;96(17):e0105022. doi: 10.1128/jvi.01050-22.
Spring Semester 2022
February 10, Colin Parrish. Evolutionary landscapes of host-virus arms races. Tenthorey et al., 2022 (Annual Reviews).
February 17, Benjamin Kaza. The Ebola virus soluble glycoprotein contributes to viral pathogenesis by activating the MAP kinase signaling pathway. Furuyama et al., 2021 (PLOS Pathogens).
February 24, Claire Birkenheuer. Nuclear dengue virus NS5 antagonizes expression of PAF1-dependent immune response genes. Petit et al., 2021 (PLOS Pathogens).
March 3, Mason Jager. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Ma et al., 2020 (Nature).
March 10, Sarah Saddoris. The m6A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay. Macveigh-Fierro, 2022 (PNAS).
March 17, Kathleen Hefferon. Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika virus replication. Zhang et al., 2022 (PNAS).
March 24. Benjamin Kaza & Viraj Upadhye. Defective interfering viral particle treatment reduces clinical signs and protects hamsters from lethal Nepah virus disease. Welch et al., 2022 (mBio).
March 31st, 2022. No presenter.
April 7. Russell Barkley. Intratumoral expression of IL-7 ad IL-12 using an oncolytic virus increases systemic sensitivity to to immune checkpoint blockade. Nakao et al., 2020 (Science Translational Medicine).
Fall Semester 2021
September 16. Colin Parrish. Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races. Tenthorey et al, 2020 (eLife).
September 23. John Parker. Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses. Geiger et al, (EMBO).
September 30. Kathleen Hefferon. Lrp1 is a host entry factor for Rift Valley fever virus.. Ganaie et al., 2021 (Cell).
October 7. Russell Barkley. A condensate-hardening drug blocks RSV replication in vivo. Risso-Ballester et al., 2021 (Nature).
October 14. Mary Machado. Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry. Lee et al., 2021 (Nature Structural & Molecular Biology).
October 21. Viraj Upadhye. Quadrivalent influenza nanoparticle vaccines induce broad protection. Boyoglu-Barnum et al., 2021 (Nature).
October 28. Esteban Flores. Alexander M Price, Robert T Steinbock, Chao Di, Katharina E Hayer, Yize Li, Christin Herrmann, Nicholas A Parenti, Jillian N Whelan, Susan R Weiss, Matthew D Weitzman.
“Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA” Nucleic Acids Research, 2021. https://pubmed.ncbi.nlm.nih.gov/34671803/.
November 4. Dan Hartman.
November 11. Gosia Rychlowska.
November 18. May Byun.
November 25. Thanksgiving.
December 2. Courtney Murdock.
December 9. Consuelo Correa.
Spring Semester 2021
January 28. Introduction to the program and discussion.
February 4. Brian Wasik and Colin Parrish. Evolution of the hemagglutinin protein of the new pandemic H1N1 influenza virus: maintaining optimal receptor binding by compensatory substitution. de Vries et al, 2013 (Journal of Virology).
February 11. Kathleen Hefferon. COVID-19-neutralizing antibodies predict disease severity and survival. Garcia-Beltran et al, 2021 (Cell).
February 18. Sara Cherry. Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs against SARS-CoV-2. Dittmar et al, 2021 (Cell).
February 25. Jessica Noll. African Swine Fever Virus Protein pE199L Mediates Virus Entry by Enabling Membrane Fusion and Core Penetration. Matamoros et al, 2020 (Host Microbe Biology).
March 4. Josh Chappie. Bacterial Retrons Function In Anti-Phage Defense. Bernheim et al, 2020 (Cell).
March 11. Alison Stout. Infectivity and pathogenicity of different hepatitis E virus genotypes/subtypes in rabbit model. Li et al, 2020 (Emerging Microbes & Infections).
March 18. Shaun Cross. Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage. Smith et al, 2021 (Journal of Virology).
March 25. Kathleen Hefferon. Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen. Maclean et al, 2021 (PLOS Biology).
April 1. Mary Machado. Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry. Lee et al, 2021 (Nature Structural & Molecular Biology).
April 8. Simon Früh. Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity. Larsen et al, 2021 (Science).
April 15. Sarah Saddoris. Kaposi’s Sarcoma-Associated Herpesvirus Processivity Factor, ORF59, Binds to Canonical and Linker Histones, and Its Carboxy Terminus Is Dispensable for Viral DNA Synthesis. Gutierrez et al, 2021 (Journal of Virology).
April 29. Mason Jager. A hepatitis B virus causes chronic infections in equids worldwide. Rasche et al, 2021 (PNAS).
May 6. Annie Chien. Coinfection with influenza A virus enhances SARS-CoV-2 infectivity. Bai et al, 2021 (Cell Research).
May 13. May Byun. Activation of STING signaling pathway effectively blocks human coronavirus infection. Liu et al, 2021 (Journal of Virology).
May 20. Fikret Aydemir. Super resolution microscopy and deep learning identify Zika virus reorganization of the endoplasmic reticulum. Long et al, 2020 (Scientific Reports).
Fall Semester 2020
September 3. Colin Parrish. Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age; 2000-year-old pathogen genomes reconstructed from metagenomic analysis of Egyptian mummified individuals; Evolutionary History of Endogenous Human Herpesvirus 6 Reflects Human Migration out of Africa. Mühlemann et al, 2020 Neukamm et al, 2020 Aswad et al, 2021.
September 10. Brian Wasik. Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Powell et al, 2020.
September 17. Jessica Noll. Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans. Richards et al, 2020.
September 24. Sarah Saddoris. Formation of adenovirus DNA replication compartments and viral DNA accumulation sites by host chromatin regulatory proteins including NPM1. Genoveso et al, 2020 (The FEBS Journal).
October 1. Gabriela Mansano. Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells. Peng et al, 2020 (PLOS Pathogens).
October 8. Eun Jin and Victoria Ortega. Efficacy of microbicides for inactivation of Ebola–Makona virus on a non‑porous surface: a targeted hygiene intervention for reducing virus spread. Cutts et al, 2020 (Scientific Reports).
October 15. David Buchholz. Update on his project.
October 22. John Parker. Influenza Virus Repurposes the Antiviral Protein IFIT2 to Promote Translation of Viral mRNAs. Tran et al, 2020 (Nature Microbiology).
October 29. Simon Früh. Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals. Zheng et al, 2020 (Journal of Virology).
November 12. Maureen Fernandes. Human Cytomegalovirus Utilizes Extracellular Vesicles To Enhance Virus Spread. Streck et al, 2020 (Journal of Virology).
November 19. Esteban Flores Cortes. Jumping back and forth: anthropozoonotic and zoonotic transmission of SARS-CoV-2 on mink farms. Munnink et al, 2021 (Science).
May Byun and Brian Imbiakha. HTCC as a Polymeric inhibitor of SARS-CoV-2 and MERS-CoV. Milewska et al, 2021 (Journal of Virology).
Spring Semester 2020
January 22. Brian Wasik and Nicole Andre. A brief primer and update on the ongoing nCoV2019 outbreak.
January 29. Hector Aguilar-Carreno. Development of a highly effective African swine fever virus vaccine by deletion of the I177L gene results in sterile immunity against the current epidemic Eurasia strain. Borca et al, 2020 (Journal of Virology).
February 5. Colin Parrish. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Li et al, 2020 (Nature Comunications)
February 12. Joy Tomlinson. Use of an Outbred Rat Hepacivirus Challenge Model for Design and Evaluation of Efficacy of Different Immunization Strategies for Hepatitis C Virus. Atcheson et al, 2019 (Hepatology).
February 19. Ian Voorhees. An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity. Athukoralage et al, 2020 (Nature).
February 26. Alison Stout. Efficacy of orally administered porcine epidemic diarrhea vaccine-loaded hydroxypropyl methylcellulose phthalate microspheres and RANKL-secreting L. lactis. Choi et al, 2020 (Veterinary Microbiology).
March 4. Esteban Flores. Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol. Müller et al, 2020 (Antiviral Research).
March 11. John Parker. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Hoffmann et al, 2020 (Cell).
March 25. Maureen Fernandez. The proximal origin of SARS-CoV-2. Anderson et al, 2020 (Nature Medicine).
April 8. Consuelo Correa. A highly potent trimeric derivative of artesunate shows promising treatment profiles in experimental models for congenital HCMV infection in vitro and ex vivo. Jacquet et al, 2020 (Antiviral Research).
April 15. Mason Jager. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–CoV-2. Shi et al, 2020 (Science).
April 22. Leonardo Caserta. Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover. Peel et al, 2019 (Emerging Microbes & Infections).
April 29. Manvendra Singh and Cedric Feschotte. Review of SARS-CoV-2 and an evolutionary analysis of ACE2 and other host factors that influence susceptibility to infection.
May 6. Fikret Aydemir. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Gordon et al, 2020 (Nature).
May 20. John Parker. Research update; grant proposal.
May 27. Kathleen Hefferon. New ideas about COVID-19, based on a project with Dr Sachdev Sidhu at the University of Toronto, who just made a synthetic antiviral peptide to COVID19’s protease..
June 4. Gary Whittaker. Discussed the recent data on the origins of the SARS CoV-2.
Fall Semester 2019
September 4. Colin Parrish. Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans. Soh et al, 2019 (eLife).
September 11. Eun Jin Choi. A near-full-length HIV-1 genome from 1966 recovered from formalin-fixed paraffin-embedded tissue. Gryseels et al, 2019 (PNAS).
September 18. Lok Raj Joshi. HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations. Drayman et al, 2019 (eLife).
September 25. Karen Barnard. Discovery of novel custacean and cephalopod flaviviruses. Parry and Asgari, 2019 (Journal of Virology).
October 2. Diego Diel. Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Hagan et al, 2019 (Cell).
October 9. Abrrey Monreal. Circadian control of lung inflammation in influenza infection. Sengupta et al, 2019 (Nature Communications).
October 16. Maureen Fernandes. A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells. Guo et al, 2019 (Nature Communications).
October 23. Gosia Rychlowska. Subgenomic flavivirus RNA binds the mosquito DEAD/H-box helicase ME31B and determines Zika virus transmission by Aedes aegypti. Goertz et al, 2019 (PNAS).
October 30. Consuelo Correa Sierra. A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model. Yant el al, 2019 (Nature Medicine).