[New Publication]EMBO J: Two disctinct domains of basal IFE suggest tissue adaptation to differential environmental challenges
August 25, 2022
Adult skin interfollicular epidermis (IFE) serves as an essential body barrier to environmental insults, yet its composition and renewal mechanisms remain debated. This work by Sangeeta and Seona in our lab identifies two distinct spatial domains of the basal IFE in mouse and human, suggesting tissue adaptation to differential environmental challenges. Congratulations to Sangeeta and Seona!
Ghuwalewala, S., Lee, S., Jiang, K., Baidya, J., Chovatiya, G., Kaur, P., Shalloway, D., and Tumbar, T. (2022). Binary organization of epidermal basal domains highlights robustness …
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Nina published a new review in EMBO Journal!
May 8, 2021
Earlier this year, Seona published a review summarizing recent findings on intrinsic and extrinsic mechanisms regulating hair follicle stem cells (HFSCs). Its sibling paper, titled “Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis” by Nina, is also now available online! While stem cells are tightly regulated by their environment, the stem cell niche, the reverse direction wherein stem cells actively regulating their niches is also an important part of tissue homeostasis. This new review from our lab systematically discusses recent findings on the outward signals from HFSCs to their niches and provides more insights towards …
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Seona and Gopal published two new papers
January 25, 2021
Two papers were published on Experimental Dermatology!
The first one, titled “Stem Cell Intrinsic Mechanisms Regulating Adult Hair Follicle Homeostasis” by Seona, with contribution also from Nina, is a comprehensive review summarizing recent findings on adult hair follicle stem cell (HFSC) regulation, which involves both cell-intrinsic mechanisms and extrinsic signals from surrounding microenvironment. Factors discussed includes transcriptional factors, super-enhancers, epigenetic modifications, signaling pathways, non-coding RNAs and metabolic controls, so this is a great steppingstone for researchers looking into the mechanisms governing HFSC.
The …
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Undergrad Sara Ragi Joins the lab
June 15, 2015
Sara Ragi, a sophomore undergraduate studying Biology and Society, joined the lab and will be working with Eva Leung on investigating heterogeneity in early skin progenitors.
Aiko Sada-Nishimura Wins First Place 2015 Stem Cell Symposium Poster
June 13, 2015
With her poster on defining the cellular lineage hierarchy in adult skin epidermis!
2015 Stem Cell Symposium
The 5th annual Stem Cell Symposium featured exciting talks by Tudorita Tumbar, Paul Frenette, Jan Lammerding, William Lowry, and Sally Temple ranging from hematopoietic stem cell niches to using stem cell models to study neurodegenerative diseases.