- TOX 3070 Pesticides and the Environment (ENT 3070) Fall. 2 credits. Prerequisites: BIOG 1101-1102 or equivalent. Instructor: J.G. Scott. A survey of the different types of pesticides, their uses, properties, and effects on the environment. Discussion of the risks, benefits, regulation, politics, and current controversies associated with pesticide use and genetically modified crops.
- TOX 4370 Eukaryotic Cell Proliferation (BIOBM 4370) Spring. Variable credits. Students may take lectures for 2 credits, or take lectures and discussions for 3 credits. Enrollment for discussion section is limited to 20 students, with priority given to graduate students. Prerequisite: BIOG 1101-1102 or BIOG 1105-1106 and BIOBM 3300 or BIOBM 3310/3320. Recommended: BIOGD 2810 and BIOBM 4320. Instructor: S. Lee. The course covers a wide spectrum of issues related to cell proliferation in eukaryotes. Lectures include various aspects of the regulation of cell division cycle and signal transduction pathways, with additional topics on oncogenesis, cell aging, and cell death. The facts as well as concepts and logics behind findings are presented in the lectures. Research articles are analyzed and discussed in depth during discussion section.
- TOX 4900 Insect Toxicology and Insecticidal Chemistry (ENTOM 4900) Spring. Odd Years. 3 credits. Prerequisites: general chemistry. Instructor: J.G. Scott. The history, metabolism, and mechanism of action of genetically modified, synthetic, and naturally occurring insecticides. Insecticide resistance, resistance mangement, and new approaches to insect control with genetically modified organisms are discussed.
- *TOX 5970 Risk Analysis and Management (CEE 5970) Spring. 3 credits. Prerequisite: An introduction to probability and statistics course e.g. CEE 3040, ENGRD 2700, ILSRT 2100, BTRY 2610 or AEM 2100; and two semesters of calculus. Senior or graduate student standing or by permission of instructor. Instructor: J. R. Stedinger. Course develops a working knowledge of risk terminology and reliability engineering, analytic tools and models used to analyze environmental and technological risks, and social and psychological risk issues. Discussions address life risks in the United States historical accidents, natural hazards, transportation risks, industrial accidents, waste incineration, air pollution modeling, public health, regulatory policy, risk communication, and risk management.
- *TOX 6100 Introductory Chemical & Environmental Toxicology (also BIOMI 6100) Fall. 3 credits. Prerequisite: graduate standing in the field or consent of the instructor. Instructor: A.G. Hay Introduction to the general principles of toxicology including the sources, mechanisms, and targets of toxic agents. Special attention is given to the interaction between toxic agents and biological systems at both the organismal and ecological level. The effects of both anthropogenic and natural toxins are examined with respect to genetic and developmental toxicity as well as carcinogenesis and specific organ toxicity.
- *TOX 6110 Molecular Toxicology (NS 6110) Spring. Offered Odd-Numbered Spring Semesters. 3 credits. Prerequisites: TOX 6100 or the equivalent in the area of introductory toxicology or permission of the instructors. Instructors: S. Bloom, R. Dietert, B. Strupp. This course is focused on the metabolism of drugs and environmental toxicants to reactivate forms that can modify DNA and proteins and induce target organ toxicity as well as mutations and cancer. Factors and pathways that can modulate toxic effects including polymorphic drug-metabolizing enzymes, stress-activated signal transduction, and DNA repair are also emphasized. The uses of molecular and cellular stress markers for assessment of toxicant exposure and health risks are discussed.
- *TOX 6990 Toxicology Journal Club (BIOMI 6990) Spring only. 1 credit. Required for Environmental Toxicology students until after they complete their A-Exam. A faculty facilitated review of current articles in various areas of toxicology with an emphasis on the development of student presentation skills.
- TOX 7010 Mouse Pathology and Transgenesis (VTBMS 7010) Spring only. 1 credit. Letter grades only. Prerequisites: basic course in histology (BIOAP 413 or equiv.) is highly recommended, or permission of instructor. Letter grades only. Instructor: A. Nikitin. Introductory course in contemporary mouse pathobiology explains principles and methods of pathology and transgenesis. In addition to coverage of development, anatomy, histology and pathology of organs and systems, the course focuses on systematic evaluation of new genetically modified mice, with particular attention to such topics as experimental design, validation of mouse models, and identification of novel phenotypes. This course includes supervised mouse necropsy.
- *TOX 7020 Seminar in Toxicology (NS 7020) Spring. 1 credit. The seminar program covers varied topics in biochemical, genetic, nutritional, veterinary, and regulatory toxicology as well as ecotoxicology and environmental chemistry. Included are presentations of basic research studies as well as fundamental concepts and research activities involving environmental problems of a toxicological nature. Presentations are given by speakers from Cornell and visitors.
- TOX 7130 Cell Cycle Analysis (VTBMS 7130) Spring. 1 credit. S-U grades only. Instructor: A. Yen This one-cerdit module presents a brief historical review of the cell cycle; a summary of cell cycle regulatory processes; and practical methods for cell cycle analysis, including mathematical representations. Topics inclukde growth control of bacterial cell cycle, including chemostats, mammalian cell tissue culture, cell synchronization, flow cytometry, age-density representation, G1 regulation, labile regulatory protein models, cell transformation, regulation by growth factors and the cytoskeleton, cyclin/E2F/RB regulatory model, practical examples for analysis of cell cycle phase durations, cell cycle phase specific growth factor sensitivity, timing or RB protein phosphorylation within the cell cycle. The objective of the course is to present graduate students with methods for cell cycle analyses that will be used in their research.
- *TOX 8900 Masters Thesis & Research Fall/Spring. Credit to be arranged. Prerequisite: permission of the chair of the graduate committee and instructor.
- *TOX 9900 Doctoral Thesis & Research Fall/Spring. Credit to be arranged. Prerequisite: permission of the chair of the graduate committee and instructor.
