Different gametogenesis states uniquely impact longevity in Caenorhabditis elegans.
Sex-specificity of the C. elegans metabolome. Nat Commun. 2023 Jan 19;14(1):320. doi: 10.1038/s41467-023-36040-y. PMID: 36658169
CUT&RUN for Chromatin Profiling in Caenorhabditis elegans. Felicity J. Emerson, Siu Sylvia Lee. First published: 17 June 2022. https://doi.org/10.1002/cpz1.445
Region-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegans. PLoS Genet. 2021 Sep 10;17(9):e1009432. doi: 10.1371/journal.pgen.1009432. eCollection 2021 Sep. PMID: 34506495
Chromatin Immunoprecipitation from C. elegans somatic cells. Pu M, Lee SS. 2020. Methods Molecular Biology. 2020;2144:171-175. doi: 10.1007/978-1-0716-0592-9_15. PMID: 32410034
A memory of longevity. Elife. 2020 Jan 24;9:e54296. doi: 10.7554/eLife.54296. PMID: 31975689
Unique patterns of trimethylation of histone H3 lysine 4 are prone to changes during aging in Caenorhabditis elegans somatic cells. Pu M, Wang M, Wang W, Velayudhan SS, Lee SS. PLoS Genet. 2018 Jun 18;14(6):e1007466. doi: 10.1371/journal.pgen.1007466. eCollection 2018 Jun. PMID: 29912876
SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. Wang W, Chaturbedi A, Wang M, An S, Santhi Velayudhan S, Lee SS. Elife. 2018 May 1;7. pii: e34970. doi: 10.7554/eLife.34970. PMID: 29714684
Chang HW, Pisano S, Chaturbedi A, Chen J, Gordon S, Baruah A, Lee SS. Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans. Aging Cell. 2017 May 30. doi: 10.1111/acel.12619. [Epub ahead of print] PMID: 28560849
Rottiers V, Francisco A, Platov M, Zaltsman Y, Ruggiero A, Lee SS, Gross A, Libert S. MTCH2 is a conserved regulator of lipid homeostasis. Obesity (Silver Spring). 2017 Mar;25(3):616-625. doi: 10.1002/oby.21751. Epub 2017 Jan 27. PMID: 28127879
Lee SS, Tyler JK. Physiology: Stressed-out chromatin promotes longevity. Nature. 2016 Jun 30;534(7609):625-6. doi: 10.1038/534625a. PMID: 27357789
M. Pu, Z. Ni, M. Wang, X. Wang, J.G. Wood, S.L. Helfand, H. Yu, S.S. Lee. Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span. Genes & Development, 2015 Apr 1;29(7):718-31. doi: 10.1101/gad.254144.114. PMID: 25838541
Jin Y, Shenoy AK, Doernberg S, Chen H, Luo H, Shen H, Lin T, Tarrash M, Cai Q, Hu X, Fiske R, Chen T, Wu L, Mohammed KA, Rottiers V, Lee SS, Lu J. FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Cancer Lett. 2015 Jun 28;362(1):70-82. doi: 10.1016/j.canlet.2015.03.037. Epub 2015 Mar 28. PMID: 25827072
H.W. Chang, L. Shtessel, S.S. Lee. Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans. Free Radical Biology and Medicine, 2015 Jan;78:168-78. doi: 10.1016/j.freeradbiomed.2014.10.576. Epub 2014 Nov 4. PMID: 25450327
Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ. Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4458-67. doi: 10.1073/pnas.1411199111. Epub 2014 Oct 6. PMID: 25288734
A. Baruah, H.W. Chang, M. Hall, J. Yuan, S. Gordon, E. Johnson, L. Shtessel, W.B. Derry, and S.S. Lee. CEP-1, the C. elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants. 2013. PLoS Genetics, 10(2):e1004097. doi: 10.1371/journal.pgen.1004097. eCollection 2014 Feb. PMID: 24586177
Iwata TN, Cowley TJ, Sloma M, Ji Y, Kim H, Qi L, Lee SS. The Transcriptional Co-Regulator HCF-1 Is Required for INS-1 β-cell Glucose-Stimulated Insulin Secretion. PLoS One. 2013 Nov 8;8(11):e78841. doi: 10.1371/journal.pone.0078841. [PubMed]
Vayndorf EM, Lee SS, Liu RH. Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods. 2013 Jul;5(3):1236-1243.
G. Rizki, C.L. Picard, C. Pereyra, and S.S. Lee. 2012. Host Cell Factor 1 Inhibits SKN-1 to Modulate Oxidative Stress Responses in C. elegans. Aging Cell. May 8. doi: 10.1111/j.1474-9726.2012.00831.x. [PubMed]
Lee SS, Schroeder FC. 2012. Steroids as central regulators of organismal development and lifespan. Lee SS, Schroeder FC. PLoS Biol. 2012;10(4):e1001307. [PubMed]
Z. Ni, A. Ebata A, E. Alipanahiramandi E, and S.S. Lee. 2012. Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans. Aging Cell. 11(2):315-25. [PubMed]
G. Rizki, T.N. Iwata, J. Li, C.G. Riedel, C.L. Picard, M. Jan, C.T. Murphy, and S.S. Lee. 2011. The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR‐2.1/SIRT1 Collaborate to Regulate DAF‐16/FOXO. PLoS Gen. 7(9): e1002235. [PubMed]
L. Walter, A. Baruah, H.W. Chang, H. Pace, S. S. Lee. 2011. The Homeobox Protein CEH-23 Mediates Prolonged Longevity in Response to Impaired Mitochondrial Electron Transport Chain in C. elegans. PLoS Biology, 9(6): e1001084. [PubMed]
C. Yang, D. Chen, S. S. Lee*, L. Walter* (*co-corresponding authors). 2011. The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate C. elegans longevity. Aging Cell, 10(4): 724-8. [PubMed]
A. de Lencastre, Z. Pincus, K. Zhou, M. Kato, S.S. Lee, F.J. Slack. 2010. MicroRNAs both promote and antagonize longevity in C. elegans. Curr. Biol. 20(24):2159-68. [PubMed]
Z. Ni and S. S. Lee. 2010. RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans. Brief Funct Genomics and Proteomics, 9(1):53-64. (Review) [PubMed]
L. Walter and S. S. Lee. 2009. Mitochondria as a Key Determinant of Aging. Encyclopedia of Life Sciences. (Review) [PDF]
N. Liachko, R. Davidowitz, and S. S. Lee. 2009. Combined informatic and expression screen identifies the novel DAF-16 target HLH-13. Dev. Biol. 327(1):97-105. [PubMed]
J. Li, A. Ebata, Y. Dong, G. Rizki, T. Iwata, and S. S. Lee. 2008. C. elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biology, 2008 Sep 30;6(9):e233. [PubMed]
J. Li, M. Tewari, M. Vidal, and S. S. Lee. 2007. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev. Biol. 301(1):82-91. [PubMed]
E.R. Troemel, S.W. Chu, V. Reinke, S. S. Lee*, F.M. Ausubel*, D.H. Kim.* (*equal contribution) 2006. p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans. PLoS Genet. 2(11):e183. [PubMed]
Lee, S. S. 2006. Whole genome RNAi screens for increased longevity: Important new insights but not the whole story. (Review) Exp Gerontol. 41(10):968-73. [PubMed]
Lee, S. S. 2005. Interfering with longevity. (Perspective) Sci Aging Knowledge Environ. 2005(35): pe26. [PubMed]
Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G.*, Lee, S. S.* (*equal contribution) 2005. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19(13): 1544-55. [PubMed]
Lee, S. S., Kennedy, S., Tolonen, A., and Ruvkun, G. 2003. DAF-16 target genes that control C. elegans lifespan and metabolism. Science, 300: 644-647. [PubMed]
Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. 2003. A systematic RNAi screen reveals a critical role for mitochondria in C. elegans longevity. Nature Genetics 33: 40-48. [PubMed]