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Publications

2025

  1. Favakeh, A., Mokhtare, A., Zhang, H., Ren, Y.A., and Abbaspourrad, A. (2025) On-chip oocyte cumulus removal using vibration-induced flow. Lab on a Chip, DOI: 10.1039/D5LC00414D.
  2. Hanxue Zhang, Rainer B Lanz, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Yi Athena Ren. CCAAT/Enhancer-Binding Proteins α and β Regulate Ovulation and Gene Expression via Dose- and Stage-Dependent Mechanisms. Endocrinology (Selected as the feature article at the Endocrinology homepage), 166(7):bqaf081
  3. Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeong Lee, Jennifer K Grenier, Paul R. Munn, Cecilia M. Ljungberg, Rebecca B Williams, Rainer B Lanz, Yu-Hsiang Liao, Yi A. Ren. Semaphorin 3E-Plexin-D1 pathway downstream of the luteinizing hormone surge regulates ovulation, granulosa cell luteinization, and ovarian angiogenesis in mice. Advanced Science, e17163.

2024

  1. Wen-Jou Chang, Maria S. Baker, Elenora Laritsky, Chathura J. Gunasekara, Uditha Maduranga, Justine C. Galliou, Joseph W. McFadden, Jessica R. Waltemyer, Bruce Berggren-Thomas, Briana N. Tate, Hanxue Zhang, Benjamin D. Rosen, Curtis P. Van Tassell, George E. Liu, Christan Coarfa, Yi Athena Ren (Co-corresponding author) & Robert A Waterland (Co-corresponding author). Systemic interindividual DNA  methylation variants in cattle share major hallmarks with those in humans. Genome Biology, 25(1):185.
  2. Madhav Mantri, Hanxue Zhang, Emmanuel Spanos, Yi A Ren (Co-corresponding author), Iwijn De Vlaminck (Co-corresponding author). A spatiotemporal molecular atlas of the ovulating mouse ovary. Proc Natl Acad Sci USA (PNAS), 121(5):e2317418121. 

2023

  1. Madhav Mantri, Hanxue Zhang, Emmanuel Spanos, Yi A Ren (Co-corresponding author), Iwijn De Vlaminck (Co-corresponding author) (2023) A spatiotemporal molecular atlas of the ovulating mouse ovary. BioRxiv.

2019

  1. Ren YA (Corresponding author), Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Philips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Coll TF, Richards JS. S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight, 5(14):e126325.

Before 2019

  1. Richards JS, Ren YA, Candelaria NC, Adams JE, Rajkovic A (2017). Ovarian theca cell recruitment, differentiation, and impact on fertility: 2017 update. Endocrine Reviews, 39(1):1-20.
  2. Philippe York (Co-first author), Yi Athena Ren (Co-first author), Jianqiao Liu, Bin Zhang, Fang Wang, Aijun Zhang, Glenn E. Winnier, Paul Webb, Xuefeng Xia, Pumin Zhang (2016). Growth arrest specific-2 is a critical mediator of germ cell cyst breakdown and folliculogenesis. Scientific Reports,13:6:34956.
  3. Jaye Adams, Zhilin Liu, Yi Athena Ren, Wan-Song Wun, Wei Zhou, Shlomit Kenigsberg, Clifford Librach, Cecilia Valdes, William Gibbons, and JoAnne Richards (2016). Enhanced inflammatory transcriptome in the granulosa cells of women with polycystic ovarian syndrome. Journal of Clinical Endocrinology and Metabolism, 101(9):3459-68.
  4. Ren YA, Mullany LK, Liu Z, Wong KK, Lonzano G, Herron A, Richards JS (2016). Mutant tumor protein p53 promotes epithelial ovarian cancer by regulating tumor differentiation, metastasis, and responsiveness to steroid hormones. Cancer Research, 76(8):2206-18.
  5. Ren YA, Liu Z, Mullany LK, Fan CM, Richards JS (2016) Growth arrest specific-1 (GAS1) is a novel modulator of ovulation and corpus luteum function. Biology of Reproduction, 94(2):44.
  6. Mullany LK, Wong KK, Marciano DC, Katsonis P, King-Crane ER, Ren YA, Lichtarge O, Richards JS (2015). Specific TP53 mutants overrepresented in ovarian cancer impact CNV, TP53 activity, response to nutlin-3a, and cell survival. Neoplasia, 17(10):789-803.
  7. Liu Z, Ren YA, Pangas SA, Adams J, Zhou W, Castrillon DH, Wilhelm D, Richards JS (2015). FOXO1/3 and PTEN deletion in granulosa cells promotes ovarian granulosa cell tumor. Molecular Endocrinology, 29(7):1006-24.
  8. Mullany LK, Liu Z, Wong KK, Deneke V, Ren YA, Herron A, Richards JS (2014). Tumor suppressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases. Molecular Endocrinology, 28(1):127-37.
  9. Yi Ren, Robert G. Cowan, Fernando F. Migone, Susan M. Quirk (2012). Over-activation of hedgehog signaling alters the development of the ovarian vasculature in mice. Biology of Reproduction, 86(6):174.
  10. Fernando F. Migone, Yi Ren, Robert G. Cowan, Rebecca M. Harman, AY Nikitin, Susan M. Quirk (2012). Dominant activation of the hedgehog signaling pathway alters development of the female reproductive tract. Genesis, 50(1):28-40.
  11. Rebecca M. Harman, Robert G. Cowan, Yi Ren, Susan M. Quirk (2011). Reduced signaling through the hedgehog pathway in the uterine stroma causes deferred implantation and embryonic loss. Reproduction, 141(5):665-74.
  12. Yi Ren, Robert G. Cowan, Rebecca M. Harman, Susan M. Quirk (2009). Dominant activation of the hedgehog signaling pathway in the ovary alters theca development and prevents ovulation. Molecular Endocrinology, 23(5):711-23.