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Olena Vatamaniuk Lab

Mineral Ion Homeostasis and Heavy Metal Detoxification

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Publications

  1. Chia, J.-C. and O. K. Vatamaniuk (2024) Shall we talk? New details in crosstalk between copper and iron homeostasis uncovered in Arabidopsis thaliana. New Phytologist.
  2. Silva, V., Lui, A.C.W., Carvalho, M.R., Namorato, F.A., Fei, Z., Rodrigues dos Reis, A., Liu, J., Vatamaniuk, O.K., Li, L. (2024) The selenium-promoted daidzein production contributes to its induced nodulation in soybean plants. Env Exp. Botany, 218, P105591.
  3. Sharma AK, Finney L, Vogt S, Vatamaniuk OK, Kim S. Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans. (2023) Front Physiol. Sep 26; 14: 1258540.
  4. Chia, JC., Woll, A.R., Smieska, L., Vatamaniuk, O.K. (2023). Visualizing Metal Distribution in Plants Using Synchrotron X-Ray Fluorescence Microscopy Techniques. In: Jeong, J. (eds) Plant Iron Homeostasis. Methods in Molecular Biology, vol 2665. Humana, New York, NY.
  5. Mahood, E., Bennett, A., Komatsu, K., Kruse, L., Lau, V., Rahmati Ishka, M., Jiang, Y., Bravo, A., Bowen, B., Louie, K., Harrison, M., Provart, N., Vatamaniuk, O. K., and Gaurav Moghe (2023). Characterization and visualization of global metabolomic responses of Brachypodium distachyon to environmental changes. Plant J. 114: 463-481.
  6. Chia, J.C., Yan, J., Rahmati Ishka, M., Faulkner, M.M., Simons, E., Huang, R., Smieska, L., Woll, A., Tappero, R., Kiss, A., Jiao, C., Fei, Z., Pineros, M., Kochian, L.V., Walker, E., Vatamaniuk, O.K. (2023).  Loss of OPT3 function decreases phloem copper levels and impairs crosstalk between copper and iron homeostasis and shoot-to-root signaling in Arabidopsis thaliana. The Plant Cell. 35(6): 2157-2185.
  7. Schmidt, S. B., Vatamaniuk, O.K. & Schneider, A. (2023). Editorial: Essential metals for plants: Uptake, transport, regulation of homeostasis and roles in plant development. Front Plant Sci 14.
  8. Vatamaniuk, O. K. (2022). Plant movement and LAC of it: How copper facilitates explosive seed dispersal. Proceedings of the National Academy of Sciences 119(28): e2208331119
  9. Nguyen, N.T., Khan, M.A., Castro‐Guerrero, N.A., Chia, J.C., Mari, S., Vatamaniuk, O.K., Jurisson, S.S., Mendoza-Cozatl, D.G. (2022), Iron availability within the leaf vasculature determines the magnitude of iron deficiency responses in source and sink tissues in Arabidopsis, Plant Cell Physiology, in press
  10. Rahmati Ishka M, Chia, Ju-Chen and Vatamaniuk., O.K. (2022) Advances in understanding of copper function and transport in plants. Pages 205-227 in: Cation transporters in plants, Editor Upadhyay, S., Elsevier. 486 pages; ISBN: 9780323885737, 032388573X.
  11. Baseggio M, Murray M, Wu D, Ziegler GR, Kaczmar N, Chamness J, Hamilton J, Buell CR, Vatamaniuk O, Buckler E, et al. & M. Gore (2021) Genome-wide association study reveals an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels. G3: Genes, Genomes, Genetics, V11:8.
  12. Jiang, Y., Chen, X., Chai, S., Sheng, H., Sha, L., Fan, X., Zeng, J., Kang, H., Zhang, H., Xiao, X., Zhou, Y., Vatamaniuk, O*. Wang, Y*. (2021) TpIRT1 is a transition metal transporter in Polish Wheat (Triticum polonicum L.) with a broad substrate specificity. The Plant Science, 312, 111058 . *Co-corresponding authors. https://doi.org/10.1016/j.plantsci.2021.111058
  13. Kim LJ, Tsuyuki KM, Hu F, Park EY, Zhang J, Iraheta JG, Chia J-C, Huang R, Tucker AE, Clyne M, Castellano C, Kim A, Chung DD, DaVeiga CT, Parsons EM, Vatamaniuk OK, Jeong J. (2021). Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Plant J, Apr.22; doi: 10.1111/tpj.15286
  14. Sheng H., Jiang Y., Rahmati Ishka M., Chia J.-C., Dokuchayeva T., Kavulych Y., Zavodna T.-O., Mendoza P., Huang R., Woll A., Romanyuk N.D., Zhou Y., Vatamaniuk O.K. (2021).  YSL3-mediated copper distribution is required for fertility, grain yield, size, and protein accumulation in Brachypodium. Plant Physiology, 186 (1): 655-676. DOI: 10.1093/plphys/kiab054
  15. Chen, C., Galon, Y., Rahmati Ishka, M., Malihi, S., Shimanovsky, V., Twito, S., Rath, A.,Vatamaniuk, O.K., Miller, G. (2020) Ascorbate peroxidase 6 delays the onset of age-dependent leaf senescence in Arabidopsis thaliana. Plant Physiology, 185(2):441-465.
  16. Rahmati Ishka M., Vatamaniuk O.K. (2020) Copper deficiency alters shoot architecture and reduces fertility of both gynoecium and androecium in Arabidopsis thaliana. Plant Direct 4 (11), e00288.
  17. Kim, S., Sharma, A., and Vatamaniuk, O.K. (2018) The N- extension domain of the C. elegans half-molecule ABC transporter, HMT-1/ABCB6, determines HMT1/ABCB6 localization to recycling endosomes. Frontiers in Physiology. 9, 885.
  18. De Benedictis, M., Brunetti, C., Brauer, E.K., Andreucci, A., Popescu, S. C., Commisso, M., Guzzo, F., Sofo, A., Castiglione, M.R., Vatamaniuk, O.K., Di Toppi, L.S. (2018) The Arabidopsis thaliana knockout mutant for phytochelatin synthase1 (cad1-3) is defective in callose deposition, bacterial pathogen defense and auxin content. Frontiers in Plant Science 9, 19.
  19. Yan, J., Chia, J-C., Sheng, H., Jung, H., Zavodna, T.-Z., Huang, R., Zhang, L., Chen., J., Fei., Z., Kochian, L., Vatamaniuk, O. (2017). Arabidopsis Pollen Fertility Requires the Transcription Factors CITF1 and SPL7 That Regulate Copper Delivery to Anthers and Jasmonic Acid Synthesis. The Plant Cell, 29 (12): 3012-3029. DOI: 10.1105/tpc.17.00363
  20. Kumar, R.K., Chu, H.-H., Abundis, C., Vasques, K., Rodrigues, C., Chia, J.-C., Huang,R., Vatamaniuk, O.K., Walker, E.L.(2017) Iron-Nicotianamine Transporters Regulate Long Distance Shoot to Root Signaling of Iron Deficiency in Arabidopsis. Plant Physiology, 175(3):1254-1268. DOI: 10.1104/pp.17.00821
  21. Lu, Z., Yan, J., Vatamaniuk, O.*, Du, Xiangge* (2016) CsNIP2;1 is a plasma membrane transporter from Cucumis sativus that facilitates urea uptake when expressed in Saccharomyces cerevisiae and Arabidopsis thaliana. Plant Cell Physiol 57(3):616-2. * indicates co-corresponding authors
  22. Gayomba, S.R., Zhai, Z., Jung, H-I., Vatamaniuk, O.K (2015) Local and Systemic Signaling of Iron Status and Its Interactions with Homeostasis of Other Essential Elements. Frontiers in Plant Sciences; 6:716.
  23. Jung, H.I., Yan, J., Zhai, Z., Vatamaniuk, O.K. (2015) Gene functional analysis using protoplast transient assays. Methods Mol Biology, 1284: 433-452.
  24. Jung, H., Gayomba, S.R., Yan, J., and Vatamaniuk, O.K. (2014) Brachypodium distachyon as a model system for studies of copper transport in cereal crops. Frontiers in Plant Sciences, 5:236
  25. Zhai, Z., Gayomba, SR., Jung, H., Vimalakumari K., Pineros M., Craft E., Rutzke M.A., Danku J., Lahner B., Punshon T., Guerinot  M.L., Salt D.E., Kochian L. and Vatamaniuk  O.K. (2014) OPT3 is a Phloem-Specific Iron Transporter that is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis. Plant Cell, 26 (5):2249-2264.
  26. Paulose, B., Chhikara, S., Coomey, J., Jung, H., Vatamaniuk, OK, and Parkash Dhankher, O. (2013) A novel γ-glutamyl cyclotransferase protects plants from heavy metals and metalloids toxicity by efficiently recycling glutamate for maintaining GSH homeostasis. Plant Cell, 25 (11):4580-95.
  27. Gayomba, S.R., Jung, H., Yan, J., Danku, J., Rutzke M., Bernal, M., Kraemer, U., Kochian, L.V., Salt, D.E., Vatamaniuk, O.K. (2013) The CTR/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in thaliana“. Metallomics, 5 (9): 1262-1275. (Themed issue with focus on Plant Metallomics).
  28. Jung, H., Gayomba, S.R., Rutzke, M.A., Craft, E. Kochian, L.V., and Vatamaniuk, O.K. (2012) COPT6 is a Plasma Membrane Transporter that Functions in Copper Homeostasis in Arabidopsis and is a Novel Target of SQUAMOSA Promoter Binding Protein-Like 7. Biol. Chem., 287, 33252-33267.
  29. Yu, D., Danku, J.M., Baxter, I., Kim, S., Vatamaniuk OK, Vitek, O., Ouzzani, M., Salt, D.E. (2012) High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome. BMC Genomics, 13, 623
  30. Yu, D., Danku, J., Baxter, I., Kim S., Vatamaniuk, O.K., Salt, D.E., Vitek, O. (2011) Noise reduction in genome-wide perturbation screens using linear mixed-effect models. 27(16):2173-80.
  31. Jung, H.I., Zhai, Z. and Vatamaniuk, O.K. (2011) Direct Transfer of Synthetic Double-Stranded RNA into Protoplasts of Arabidopsis thaliana. Methods Mol Biol, 744, 109-127.
  32. Mendoza-Cózatl, D.G, Zhai, Z., Jobe, T.O., Akmakjian, G.Z., Song, W.-Y., Limbo, O., Russell, M.R., Kozlovskyy, V.I., Martinoia, E., Vatamaniuk, O.K., Russell, P., Schroeder, J.I. (2010) Schizosaccharomyces pombe Abc2p mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. Biol. Chem., 285 (52): 40416-40426.
  33. Kim, S., Selote, D. Vatamaniuk, O.K. (2010) The N-terminal extension domain of the elegans half-molecule ABC transporter, HMT-1, is required for protein-protein interactions and function. PLoS ONE, 5(9): e12938.
  34. Tian, C., Sen, D., Shi, H., Foehr, M.L., Plavskin, Y., Vatamaniuk, O.K., Liu, Y. (2010) The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans. Development. 2010 Jul;137(14):2375-84
  35. Schwartz, M.S., Benci, J.L. Selote, D., Sharma, A., Chen, A., Dang H., Fares, H., Vatamaniuk, O.K. (2010) Detoxification of multiple heavy metals by a half-molecule ABC transporter HMT-1 and coelomocytes of Caenorhabditis elegans. PLoS ONE, 5, e9564.
  36. Zhai, Z., Jung, H., Vatamaniuk, O.K. (2009) Isolation of protoplasts from tissues of 14-days-old seedlings of Arabidopsis thaliana. J Vis. Exp., August 17; (30). pii: 1149. doi: 10.3791/1149.
  37. Zhai, Z., Sooksa-nguan, T. and Vatamaniuk, O.K. (2009) Establishing RNAi as a reverse genetic approach for gene functional analysis in protoplasts. Plant Phys., 149, 642-652. Epub 2008. 
  38. Sooksa-nguan, T., Yakubov, B., Kozlovskyy, V.I., Barkume, C.M., Howe, K.J., Thannhauser T.W., Rutzke, M.A., Hart, J.J., Kochian, L.V., Rea, P.A. and Vatamaniuk, O.K. (2009) Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. J. Biol. Chem., 284, 354-62. Epub 2008, Nov 10.
  39. Romanyuk, N.D., Rigden, D.J., Vatamaniuk, O.K., Lang, A., Cahoon, R.E., Jez, J.M., Rea, P.A.  (2006) Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase. Plant Physiol., 141, 858-69.
  40. Vatamaniuk O.K., Bucher E.A., Sundaram M.V. and Rea P.A.  (2005) CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.  J Biol Chem, 280, 23684-23690.
  41. Rea P.A., Vatamaniuk O.K., Rigden D.J. (2004) Weeds, worms and more: papain’s long-lost cousin, phytochelatin synthase. Plant Phys. 136, 2463-2474.
  42. Vatamaniuk, O.K., Mari, S., Lang A., Demkiv, L.O. and Rea, P.A. (2004) Phytochelatin synthase, a dipeptidyl transferase that undergoes multisite acylation with g-glutamylcysteine during catalysis. Stoichiometric and site-directed mutagenic analysis of AtPCS1-catalyzed phytochelatin synthesis. J. Biol. Chem. 279, 22449-22460.
  43. Vatamaniuk, M.Z., Horyn, O.V., Vatamaniuk, O.K., Doliba, N.M. (2003) Acetylcholine affects rat liver metabolism via type 3 muscarinic receptors in hepatocytes. Life Sci. 72, 1871-82.
  44. Vatamaniuk, O.K., Bucher, E.A., Ward, J.T. and Rea, P.A. (2001) A new pathway for heavy metal detoxification in animals: phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans. J. Biol. Chem., 276, 20817-20820.
  45. Vatamaniuk, O.K., Bucher, E.A. and Rea, P.A. (2002) Worms take the ‘phyto’ out of ‘phytochelatins’. Trends in Biotechnol., 20, 61-64.
  46. Vatamaniuk, O.K., Mari, S., Lu, Y. -P. and Rea, P.A. (2000) Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides. J. Biol. Chem., 275, 31451-31459.
  47. Vatamaniuk, O.K., Mari, S., Lu, Y.-P., and Rea, P.A. (1999) AtPCS1, a phytochelatin synthase from Arabidopsis: isolation and in vitro reconstitution.  Proc. Natl. Acad. Sci.  USA, 96, 7110-7115.

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