Joseph W. McFadden, Ph.D.
Assistant Professor of Dairy Cattle Biology
Northeast Agribusiness and Feed Alliance Faculty Fellow
Department of Animal Science
Our goals are to (1) define the mechanisms that mediate maternal and pathological insulin antagonism to support the development of the offspring with a focus on the sphingolipid ceramide, (2) delineate the mechanisms that limit the secretion of lipoprotein triacylglycerol during hepatic steatosis with a focus on phosphatidylcholine synthesis, and (3) assess the impact of the gastrointestinal health on liver function. To ensure impact, we are testing novel nutritional and pharmacological technologies to modify insulin action, systemic glucose utilization, hepatic lipid processing, and intestinal permeability. Our lab follows these principles:
- The practice of hypothesis-driven lipidomics is a technological advancement that can provide breakthroughs in our understanding of mammalian biochemistry and physiology.
- Metabolic disease caused by overnutrition afflicts domestic animals and humans, and the biochemical mechanisms may be similar across species.
- Actively challenging contemporary theory and industry practice is essential for progress.
- The translational application of discovery is of fundamental importance.