The Lipids Lab
Department of Animal Science
Our goals are to (1) define the mechanisms that mediate maternal and pathological insulin antagonism to support the development of the offspring with a focus on the sphingolipid ceramide, (2) delineate the mechanisms that limit the secretion of lipoprotein triacylglycerol during hepatic steatosis with a focus on phosphatidylcholine synthesis, (3) define new approaches to enhance nutrient digestibility, and (4) assess the impact of the gastrointestinal health on liver function. To ensure impact, we are testing novel nutritional and pharmacological technologies to modify insulin action, systemic glucose utilization, fatty acid absorption, hepatic lipid processing, and intestinal permeability. Our lab follows these principles:
- The practice of hypothesis-driven lipidomics is a technological advancement that can provide breakthroughs in our understanding of mammalian biochemistry and physiology.
- Actively challenging contemporary theory and industry practice is essential for progress.
- The translational application of discovery is of fundamental importance.