Liu Worm Lab

Department of Molecular Biology and Genetics

Publications

Papers on BMP signaling

Serrano, M. V., Cottier, S., Wang, L., Moreira-Antepara, S., Nzessi, A., Liu, Z., Williams, B., Lee, M., Schneiter, R. and Liu, J. (2024) The C. elegans LON-1 protein requires its CAP domain for function in regulating body size and BMP signaling. bioRxiv. doi: https://doi.org/10.1101/2024.10.01.616164.

Vora, M., Dietz, J., Wing, Z., Liu, J., Rongo, C. and Savage-Dunn, C. (2024) Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion. bioRxiv. doi: https://doi.org/10.1101/2024.06.05.597576.

DeGroot, M. S., Williams, B., Chang, T. Y., Maas Gamboa, M. L., Larus, I. M., Fromme, J. C. and Liu, J. (2023) SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans. PLoS Biol. 2023 Aug 17;21(8):e3002272. doi: 10.1371/journal.pbio.3002272 (Pubmed).

Liu, Z., Shi, H. and Liu, J. (2022) The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function. PLoS Genetics https://doi.org/10.1101/2021.11.10.468015 (Pubmed).

Tsutsui, K., Kim, H., Yoshikata, C., Kimura, K., Kubota, Y., Shibata, Y., Tian, C., Liu, J. and Nishiwaki, K. (2021) Repulsive guidance molecule acts in axon branching in Caenorhabditis elegans. Scientific Reports 11:22370. doi: 10.1038/s41598-021-01853-8 (Pubmed)

DeGroot, MS; Greer, R and Liu, J (2021). GPN-1/glypican and UNC-52/perlecan do not appear to function in BMP signaling to pattern the C. elegans postembryonic mesoderm. MicroPubl Biol. doi: 10.17912/micropub.biology.000437. (pubmed)

Liu, Z., Shi, H., Nzessi, A. K., Norris, A., Grant, B. D. and Liu, J. (2020) Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 117: 2968-2977. doi: 10.1073/pnas.1918807117. Epub 2020 Jan 27 (Pubmed)

Landstrom, M. and Liu, J. (2019) The 2019 FASEB science research conference on the TGFbeta superfamily conference: signaling in development and disease, July 28 to August 2, 2019, West Palm Beach, Florida, USA. The FASEB Journal. 33(12):13064-13067. doi: 10.1096/fj.201902632. Epub 2019 Dec 22. (Pubmed) 

Savage-Dunn, C., Gleason R. J., Liu, J. and Padgett, R. W. (2019) Mutagenesis and imaging studies of BMP signaling mechanisms in C. elegans. Methods in Molecular Biology 1891: 51-73. doi: 10.1007/978-1-4939-8904-1_6. Epub 2018 Nov 10 (Pubmed) 

DeGroot, M. S., Shi, H., Eastman, A., McKillop, A. N. and Liu, J. (2019) The C. elegans SMOC-1 protein acts cell non-autonomously to promote bone morphogenetic protein signaling. Genetics. pii: genetics.301805.2018. doi: 10.1534/genetics.118.301805. Epub 2018 Dec 5. (Pubmed)

McKillop, A. N., Shi, H. and Liu, J. (2018) A new deletion allele of sma-4. MicroPubl Biol. doi: 10.17912/Z4Z9-CE10. (Pubmed)

Shen, Q., Toulabi, L. B., Shi, H., Nicklow, E. E. and Liu, J. (2018) The forkhead transcription factor UNC-130/FOXD integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm. Developmental Biology 433(1): 75-83. Epub 2017 Nov 16 (Pubmed)

Wang, L.*, Liu, Z.*, Shi, H. and Liu, J. (2017) Two paralogous tetraspanins TSP-12 and TSP-14 function with the ADAM10 metalloprotease SUP-17 to promote BMP signaling in Caenorhabditis elegans. PLoS Genetics 13(1):e1006568. doi: 10.1371/journal.pgen.1006568. Epub 2017 Jan 9 (Pubmed)

Liu, Z., Shi, H., Szymczak, L. C., Aydin, T., Yun, S., Constas, K., Schaeffer, A., Ranjan, S., Kubba, S., Alam, E., McMahon, D. E., He, J., Shwartz, N., Tian, C., Plavskin, Y., Lindy, A., Dad, N.A., Sheth, S., Amin, N. M., Zimmerman, S., Liu, D., Schwarz, E. M., Smith, H., Krause, M. W. and Liu, J. (2015) Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. PLoS Genetics 11(5): e1005221. DOI: 10.1371/journal.pgen.1005221 (Pubmed)

Tian, C., Shi, H., Xiong, S., Hu, F., Xiong, W. and Liu, J. (2013) The neogenin/DCC homolog UNC-40 functions independently of netrin signaling to promote BMP signaling in C. elegans. Development Epub 2013 September 4. (Pubmed)

Tian, C. and Liu, J. (2013) Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling. Mol. Reprod. Dev. 9999: 1-18. Epub 2013 June 6. (Pubmed)

Tian, C., Sen, D., Shi, H., Foehr, M. L., Plavskin, Y. Vatamaniuk, O. K. and Liu, J. (2010) The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans. Development 137: 2375-2384. Epub 2010 June 9. (Pubmed)

Foehr, M. L. and Liu, J. (2008) Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGF-beta signaling. Developmental Biology 313: 256-266. Epub 2007 Oct 25. (Pubmed)

Foehr, M. F., Lindy, A. S., Fairbank, R. C., Amin, N. M., Xu, M., Yanowitz, J., Fire, A. Z. and Liu, J. (2006) An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGF-ß signaling during mesodermal patterning. Development 133: 2887-2896. (Pubmed)

Liang, J., Lints, R., Foehr, M. L., Tokarz, R., Yu, L., Emmons, S. W., Liu, J. and Savage-Dunn, C. (2003) The Caenorhabditis elegans schnurri homolog, sma-9, mediates stage- and cell type- specific responses to DBL-1 BMP-related signaling. Development 130: 6453-6464. (PubMed)

Papers on cell fate specification 

Baccas, M., Ganesan, V., Leung, A., Pineiro, L.R., McKillop, A. N., Liu, J. (2024) SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. bioRxiv. doi: https://doi.org/10.1101/2024.07.04.602042

Liu, J. and Murray, J. I. (2023) Mechanisms of lineage specification in Caenorhabditis elegans. GENETICS 225(4) iyad174. https://doi.org/10.1093/genetics/iyad174. Advance Access Publication Date: 17 October 2023. WormBook (Pubmed)

Shen, Q., Toulabi, L. B., Shi, H., Nicklow, E. E. and Liu, J. (2018) The forkhead transcription factor UNC-130/FOXD integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm. Developmental Biology 433(1): 75-83. Epub 2017 Nov 16 (Pubmed)

Shen, Q., Shi, H., Tian, C., Ghai, V. and Liu, J. (2017) The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm. Developmental Biology 429(1): 335-342. Epub 2017 Jun 11. (Pubmed)

Hale, J. J., Amin, N. M., George, C., Via, Z., Shi, H. and Liu, J. (2014) A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans. Developmental Biology 389: 137-148. Epub 2014 Feb 7. (Pubmed).

Krause, M. and Liu, J. (2012) Somatic muscle specification during embryonic and post-embryonic development in the nematode C. elegans. WIREs Developmental Biology. 1(2): 203-214. Review. DOI: 10.1002/wdev.15. Epub 2011 Dec 08 (Pubmed).

Tian, C., Shi, H., Colledge, C., Stern, M., Waterston, R. and Liu, J. (2011) The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm. Development 138: 1033-1043. Epub 2011 February 9. (Pubmed)

Amin, N.M., Shi, H. and Liu, J. (2010) The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development. Development 137:1451-1460. Epub 2010 Mar 24. (Pubmed)

Jiang, Y., Shi, H. and Liu, J. (2009) Two Hox cofactors, the Meis/Hth homolog UNC-62 and the Pbx/Exd homolog CEH-20, function together during C. elegans postembryonic mesodermal development. Developmental Biology 334:535-546. (Pubmed)

Amin, N. M., Lim, S.-E., Shi, H., Chan, T. L. and Liu, J. (2009) A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. Developmental Biology 331:350-360. (Pubmed)

Lei, H., Liu, J., Fukushige, T., Fire, A., and Krause, M. (2009) Caudal-like PAL-1 directly activates the bodywall muscle module regulator HLH-1 in C. elegans to initiate embryonic muscle gene regulatory network. Development 136: 1241-1249. Epub 2009 Mar 4. (Pubmed)

Jiang, Y., Shi, H., Amin, N. M., Sultan, I. and Liu, J. (2008) Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20. Mech. Dev. 125: 451-461. Epub 2008 Feb 2. (Pubmed)

Foehr, M. L. and Liu, J. (2008) Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGF-ß signaling. Developmental Biology 313: 256-266. Epub 2007 Oct 25. (Pubmed)

Amin, N. M., Hu, K., Pruyne, D., Terzic, D., Bretscher, A. and Liu, J. (2007) A Zn finger/FH2 domain containing protein FOZI-1 acts redundantly with CeMyoD to specify striated body wall muscle fates in the C. elegans postembryonic mesoderm. Development 134: 19-29. Epub 2006 Nov 30. (Pubmed)

Johnston R. J. Jr., Copeland, J. W., Fasnacht, M., Etchberger, J. F., Liu, J., Honig, B. and Hobert, O. (2006) An unusual Zn-finger/FH2 domain protein controls a left/right asymmetric neuronal fate decision in C. elegans. Development 133: 3317-3328. (Pubmed)

Foehr, M. F., Lindy, A. S., Fairbank, R. C., Amin, N. M., Xu, M., Yanowitz, J., Fire, A. Z. and Liu, J. (2006) An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGF-ß signaling during mesodermal patterning. Development 133: 2887-2896. (Pubmed)

Jiang, Y., Horner, V. and Liu, J. (2005) The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm. Development 132: 4119-4130.(PubMed)

Liu, J., and Fire, A. (2000). Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm. Development 127: 5179-5190. (PubMed)

Harfe, B. D., Gomes, A. Z., Kenyon, C., Liu, J., Krause, M. and Fire, A. (1998) Analysis of a Caenorhabditis elegans twist homolog identifies conserved and divergent aspects of mesodermal patterning. Genes & Dev. 12: 263-2635. (PubMed)

Papers on the nuclear envelope

Zahand, A., Williams, B. and Liu, J. (2024) Generation of a highly specific and potent antibody against Ce-lamin/LMN-1. MicroPub Biol. 2024 Aug 15:2024. doi: 10.17912/micropub.biology.001294. eCollection 2024. (Pubmed)

Barkan, R., Zahand, A. J., Sharabi, K., Lamm, A. T., Feinstein, N., Haithcock, E., Wilson, K. L.,Liu, J. and Gruenbaum, Y. (2012) Emerin the LEM2: essential roles in C. elegans development, muscle function and mitosis. Mol Biol Cell. 23: 543-552. Epub 2011 Dec 14. (Pubmed)

Golden, A., Liu, J. and Cohen-Fix, O. (2009) Inactivation of the C. elegans homolog of lipin leads to endoplasmic reticulum disorganization and defects in nuclear envelope breakdown and reassembly of the nuclear envelope. J. Cell Sci. 122: 1970-1978. (Pubmed)

Liu, J. (March 2009) Nuclear Envelope and Lamins: Organization and Dynamics. In:ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0001342.pub2].

Haithcock, E., Dayani, Y., Neufeld, E., Zahand, A. J., Feinstein, N., Mattout, A., Gruenbaum, Y. and Liu, J. (2005) Age-related changes of nuclear architecture in C. elegans. Proc Natl Acad Sci U S A. 102: 16690-16695. (PubMed). (Highlighted in PNAS 102: 16531, and featured in a commentary by Wilson, K.L. (2005) PNAS 102: 18767-18768 (Pubmed) and a News and Views article by Lans and Hoejimakers (2006) Nature 440: 32-34 (Pubmed)).

Margalit, A., Liu, J., Fridkin, A., Wilson, K. L. and Gruenbaum, Y. (2005) A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development. Novartis Found Symp. 264: 231-240; discussion 240-245.(PubMed)

Liu, J., Lee, K. K., Segura-Totten, M., Neufeld E., Wilson, K. L. and Gruenbaum Y. (2003) MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 100:4598-4603. (PubMed)

Lee, K. K., Starr, D., Cohen, M., Liu, J., Han, M., Wilson, K. L. and Gruenbaum Y. (2002) Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol. Biol. Cell 13: 892-901. (PubMed)

Gruenbaum, Y., Lee, K. K., Liu, J., Cohen, M. and Wilson, K. L. (2002) The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans. J. Cell Sci. 115: 923-929. (PubMed)

Lee, K. K., Gruenbaum, Y., Spann, P., Liu, J. and Wilson, K. L. (2000) C. elegans nuclear envelope proteins Emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis. Mol. Biol. Cell 11: 3089-3099. (PubMed)

Liu, J., Ben-Shahar, T. R., Riemer, D., Treinin, M., Spann, P., Weber, K., Fire, A. and Gruenbaum, Y. (2000). Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression and spatial organization of nuclear pore complexes. Mol. Biol. Cell 11: 3937-3947. (PubMed)

Papers on PhD work

Yu, J., Liu, J., Song, K., Turner, S. and Wolfner, M. F. (1999) Nuclear entry of the Drosophila melanogaster nuclear lamina protein YA correlates with developmentally regulated changes in its phosphorylation state. Dev. Biol. 210: 124-134. (PubMed)

Liu, J. and Wolfner, M. F. (1998) Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogaster. Mol. Cell Biol. 18: 188-197. (PubMed)

Liu, J., Lopez, J. M., and Wolfner, M. F. (1997) Developmental modulations of the nuclear envelope. Curr. Topics Dev. Biol. 35: 47-70. (PubMed)

Liu, J., Lin, H., Lopez, J. M. and Wolfner, M. F. (1997) Formation of the male pronuclear lamina in Drosophila melanogaster. Dev. Biol. 184: 187-196. (PubMed)

Liu, J., Song, K. and Wolfner, M. F. (1995) Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila. Genetics 141: 1473-1481. (PubMed)

The Liu Lab at Cornell University
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