Collins Lab Blog

Protein isoform – one phrase, many meanings

There appears to be a large variation in meaning when talking about protein isoforms, which can be quite confusing. Depending on context it can mean one or more of the following scenarios:

1) Two (or more) different genes in the same genome encoding proteins that are highly similar (<95%?).

2) One single gene that is differentially spliced, or differentially translated to create two (or more) different proteins.

3) One single protein that is differentially post-translationally modified to create two (or more) different versions of the protein.

4) Different conformations of the same protein, eg PrPc and PrPsc.

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