Publications – Chen Group

	Note: For interested readers, the Supplementary Materials to our publications are as important as the main papers. ^†Equal contribution. *Correspondence author.
(86)	W. Zhang,^† C. Harper,^† J. Lee, B. Fu, M. Ramsuhk, C. Hernandez,* P. Chen* “Transporter excess and clustering facilitate adaptor-protein shuttling for bacterial efflux” Cell Rep. Phys. Sci., pre-accepted.
(85)	U. Chakraborty,^† Y. Park,^† K. Sengupta, W. Jung, C. Joshi, D. Francis, P. Chen* “A ‘through-DNA’ mechanism for co-regulation of metal uptake and efflux” Nature Commun. 2024, 15, 10555. Preprint version: bioRxiv, https://doi.org/10.1101/2023.12.05.570191. News highlights: “New pathway found for regulating zinc in E. coli,” Cornell Chronicle, December 4, 2024 Udit’s blogpost: “Imaging a balancing act, ‘through-DNA’” on Spring Nature Research Communities. Youngchan’s blogpost: “Through DNA and Beyond: A Postdoc Journey of Collaboration and Discovery” on Spring Nature Research Communities.
(84)	W. Jung,* T.-Y. Chen, A. G. Santiago, P. Chen* “Memory effects of transcription regulator-DNA interactions in bacteria” Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2407647121.
(83)	M. Zhao, W. Li, M. Yang, Z. Zhao, R. Ye, X. Mao, P. Padgett, P. Chen* “Long-range enhancement of micropollutant adsorption on metal-promoted photocatalysts” Nature Catal. 2024, 7, 912-920. News highlights: “A touch of gold has extra reach in degrading micropollutants,” Cornell Chronicle, July 19, 2024 Ming’s blog post on Spring Nature Research Communities.
(82)	J. Lee, K. Jha, C. Harper, W. Zhang, M. Ramsukh, N. Bouklas, T. Doerr, P. Chen, C. Hernandez* “Determining the Young’s modulus of the bacterial cell envelope” ACS Biomater. Sci. Eng. 2024, 10, 2956-2966.
(81)	M. S. Alshammasi, P. Chen, F. A. Escobedo* “Revealing the origin of cooperative adsorption of chains on nanoparticle surfaces through coarse-grained simulations” Langmuir 2024, 40, 8015-8023.
(80)	L. Xu,^† R. Ye,^† M. Mavrikakis,* P. Chen* “Molecular-scale insights into cooperativity switching of xTAB adsorption on gold nanoparticles” ACS Cent. Sci. 2024, 10, 65-76.
(79)	R. Ye,^† X. Sun,^† X. Mao,^† F. Alfonso, S. Baral, C. Liu, G. Coates, P. Chen* “Optical sequencing of single synthetic polymers” Nature Chem. 2024, 16, 210-217. News highlights: “Flashy molecules decode a polymer’s lengthening chain,” Nature, https://doi.org/10.1038/d41586-023-03497-2 (2023) “Tracking polymerization with laser focus,” Chem. Eng. News. November 22, 2023 “Cornell chemists image basic blocks of synthetic polymers,” Cornell Chronicle, November 9, 2023 “Single-molecule fluorescence imaging and sequencing of single synthetic polymers,” Springer Nature, Chemistry Community, Behind-the-Paper blog by Prof. Xiangcheng Sun “Navigating the challenge: crafting data analysis pipelines for polymer imaging breakthroughs” at Springer Nature, Chemistry Community, Behind-the-Paper blog by Prof. Xianwen Mao
(78)	B. Fu,^† X. Mao,^† Y. Park, Z. Zhao, T. Yan, W. Jung, D. H. Francis, W. Li, B. Pian, F. Salimijazi, M. Suri, T. Hanrath, B. Barstow, P. Chen* “Single-cell multimodal imaging uncovers energy conversion pathways in biohybrids” Nature Chem. 2023, 15, 1400-1407. News highlights: “Imaging platform illuminates biohybrids,” Chem. Eng. News, July 27, 2023 “A multimodal imaging approach for interrogating energy-conversion pathways in biohybrids,” Nature Chemistry Research Briefing, July 27, 2023 “Imaging shows how solar-powered microbes turn CO2 into bioplastic,” Cornell Chronicle, July 27, 2023 “Imaging shows how inorganic-microbe hybrids use light to turn carbon dioxide into bioplastic,” DOE Office of Science research highlights, Nov 1, 2023
(77)	C. Harper,^† W. Zhang,^† J. Lee, J.-H. Shin, M. Keller, E. van Wijngaarden, E. Chou, Z. Wang, T. Dörr,* P. Chen,* C. J. Hernandez* “Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway” Sci. Rep. 2023, 13, 13979. Preprint version: bioRxiv, https://doi.org/10.1101/2022.09.25.509347.
(76)	S. Baral,^† C. Liu,^†,* X. Mao, G. W. Coates, P. Chen* “Tuning single polymer growth via hydrogen bonding in conformational entanglements” ACS Cent. Sci. 2022, 8, 1116-1124.
(75)	M. Suri, Z. Mohamed, S. Naser, X. Mao, P. Chen, S. Daniel,* T. Hanrath* “Bioelectronic platform to investigate charge transfer between photoexcited quantum dots and microbial outer membranes” ACS Appl. Mater. Interfaces 2022, 14, 15799-15810.
(74)	X. Mao, P. Chen* “Inter-facet junction effects on particulate photoelectrodes” Nature Mater. 2022, 21, 331-337. News highlights: “Probing the properties of interfacet junctions,” Chem. Eng. News, January 12, 2022 “3D semiconductor particles offer 2D properties,” Cornell Chronicle, January 3, 2022
(73)	R. Ye,^† M. Zhao,^† X. Mao, Z. Wang, D. A. Garzon, H. Pu, Z. Zhao, P. Chen* “Nanoscale cooperative adsorption for materials control” Nature Commun. 2021, 12, 4287. News highlights: “The many facets of cooperativity,” Nat. Rev. Mater. 2021; DOI: 10.1038/s41578-021-00368-y “Chemistry discovery could remove micropollutants from environment,” US Army DEVCOM Army Research Laboratory Public Affairs; July 14, 2021 “Small molecule plays outsize role in controlling nanoparticle,” Cornell Chronicle, July 13, 2021 Featured in Nat. Commun. Editors’ Highlights in Materials Science and Chemistry.
(72)	S. Baral, C. Liu, U. K. Chakraborty, K. Kubo, X. Mao, G. W. Coates, P. Chen* “Single-chain polymerization dynamics and conformational mechanics of conjugated polymers” Chem 2021, 7, 2175-2189. News highlights: “Magnetic tweezers reveal polymers’ hidden properties” Cornell Chronicle, June 16, 2021. “Pioneering chemistry approach could lead to more robust soft electronics,” U.S. Army DEVCOM Army Research Laboratory; June 16, 2021
(71)	X. Mao,^† R. Ye,^† P. Chen* “Fluorescence microscopy” In Springer Handbook of Advanced Catalyst Characterization, edited by Israel Wachs and Miguel A. Banares; pp285-294 (2023). Invited contribution.
(70)	S. Sarkar, X. Wang, M. Hesari, P. Chen, M. V. Mirkin* “Scanning electrochemical and photo-electrochemical microscopy on finder grids: toward correlative multi-technique imaging of surfaces” Anal. Chem. 2021, 93, 5377-5382.
(69)	J. Kang, S. J. Park, P. Chen,* J. Sung* “Stochastic kinetics of nanocatalytic systems” Phys. Rev. Lett. 2021, 126, 126001.
(68)	C. Liu,^†,* S. Baral,^† K. Gu, X. Mao, P. Chen* “Real-time single polymer growth toward single monomer resolution” Trends Chem. 2021, 3, 318-331. Invited review.
(67)	B. Fu,^† K. Sengupta,^† L. A. Genova,^† A. G. Santiago, W. Jung, L. Krzeminski, U. K. Chakraborty, W. Zhang, P. Chen* “Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria” Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 13248-13255. News highlights: “Researchers track how bacteria purge toxic metals,” Cornell Chronicle, May 28, 2020.
(66)	M. Zhao, P. Chen* “Exploring plasmonic photocatalysis via single-molecule reaction imaging” Nano Lett. 2020, 20, 2939-2940. Invited Perspective.
(65)	W. Jung, K. Sengupta, B. Wendel, J. D. Helmann, P. Chen* “Biphasic unbinding of a metalloregulator from DNA for transcription (de)repression in live bacteria” Nucleic Acids Res. 2020, 48, 2199-2208. Preprint version: bioRxiv, 434738; https://doi.org/10.1101/434738; Oct 4, 2018. News highlights: Selected as NAR Breakthrough Article, which, according to NAR, are “those that appear to solve a long-standing problem in their field, or provide exceptional new insight and understanding into an area of research that will clearly motivate and guide new research opportunities and directions. They highlight the top 1 to 2% of papers that NAR receives for publication.” Recommended as “exceptional” by F1000Prime. https://doi.org/10.3410/f.737317970.793572020.
(64)	L. A. Genova,^† M. F. Roberts,^† Y.-C. Wong, C. E. Harper, A. G. Santiago, B. Fu, A. Srivastava, W. Jung, L. M. Wang, L. Krzeminski, X. Mao, X. Sun, C.-Y. Hui, P. Chen,* C. J. Hernandez* “Mechanical stress compromises multicomponent efflux complexes in bacteria” Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 25462-25467. Preprint version: bioRxiv 571398; https://doi.org/10.1101/571398; Mar 8, 2019. News highlights: “Physical forces affect bacteria’s toxin resistance, study finds,” Cornell Chronicle, December 5, 2019. See also EurekAlert version.
(63)	X. Mao, C. Liu, M. Hesari, N. Zou, P. Chen* “Super-resolution imaging of nonfluorescent reactions via competition” Nature Chem. 2019, 11, 687-694. News highlights: “Extending fluorescence microscopy to nonfluorescent reactions,” Chem. Eng. News, July 12, 2019. “Breakthrough imaging of non-fluorescent reactions,” Microscopy and Analysis editorial, July 10, 2019. “Minder zien, meer weten,” Dutch news platform [C2w]. “New imaging method aids in water decontamination,” Cornell Chronicle, July 8, 2019. See also EurekAlert!, Phys.org, Nanowerk, Newswise, ScienceDaily, Environmental News Network, Azooptics, Science360 News. “Superresolution Imaging Method Aids in Water Decontamination,” Photonics media.
(62)	J. B. Sambur,* D. P. Shepherd, M. Hesari, M. Van Erdewyk, E. Choudhary, P. Chen* “Correlated single-molecule reaction imaging and photocurrent measurements reveal underlying rate processes in photoelectrochemical water splitting” J. Electrochem. Soc. 2019, 166, H3286-H3293.
(61)	R. Ye,^† X. Mao,^† X. Sun, P. Chen* “Analogy between enzyme and nanoparticle catalysis: a single-molecule perspective” ACS Catal. 2019, 9, 1985-1992.
(60)	M. Hesari, J. Sambur, X. Mao, W. Jung, P. Chen* “Quantifying photocurrent loss of a single particle-particle interface in nanostructured photoelectrodes” Nano Lett. 2019, 19, 958-962. News highlights: “A first: Cornell researchers quantify photocurrent loss in particle interface,” Cornell Chronicle, January 30, 2019.
(59)	N. Zou, G. Chen, X. Mao, H. Shen, E. Choudhary, X. Zhou, P. Chen* “Imaging catalytic hotspots on single plasmonic nanostructures via correlated super-resolution and electron microscopy” ACS Nano 2018, 12, 5570-5579.
(58)	M. Hesari,^† X. Mao,^† P. Chen* “Charge carrier activity on single-particle photo(electro)catalysts: Toward function in solar energy conversion” J. Am. Chem. Soc. 2018, 140, 6729-6740. Invited Perspective. News highlights: JACS spotlights: “Photo(electro)catalysts, ready for their extreme close-up,” J. Am. Chem. Soc. 2018, 140, 6727-6728.
(57)	N. Zou,^† X. Zhou,^† G. Chen,^† N. M. Andoy, W. Jung, G. Liu, P. Chen* “Cooperative communication within and between single nanocatalysts” Nature Chem. 2018, 10, 607-614. News highlights: “Communicating catalysts,” Nature Chem. 2018, 10, 580-582. “Nanoparticle catalysts communicate across distances,” Chem. Eng. News 2018, 96, 6. “Communication is key in nanocatalysts too,” Nanotechweb.org, UK Institute of Physics. “Understanding nanocatalysts’ ‘talk’ could better inform design,” Cornell Chronicle, March 26, 2018.
(56)	T.-Y. Chen,* Y.-S. Cheng, P.-S. Huang, P. Chen* “Facilitated unbinding via multivalency-enabled ternary complexes: New paradigm for protein-DNA interactions” Acc. Chem. Res. 2018, 51, 860-868. Invited contribution.
(55)	G. Chen, N. Zou, B. Chen, J. B. Sambur, E. Choudhary, P. Chen* “Bimetallic effect of single nanocatalysts visualized by super-resolution catalysis imaging” ACS Cent. Sci. 2017, 3, 1189-1197. News highlights: “Method reveals secrets of bimetallic catalysts” Chem. Eng. News 2017, 95, 9. “First-ever visualization of enhanced catalytic activity reported,” Cornell Chronicle, Nov 1, 2017.
(54)	C. Liu,^† K. Kubo,^† E. Wang,^† K.-S. Han, F. Yang, G. Chen, F. A. Escobedo,* G. W. Coates,* P. Chen* “Single polymer growth dynamics” Science 2017, 358, 352-355. News highlights: Army Research Lab YouTube video: “Army research is paving way to materials of the future.” “Army research leading to materials of the future wins national award,” Army Research Lab press release; February 6, 2018. “Research of the Year” Chem. Eng. News. 2017, 95(49), 27. “Polymers: Watching growth, step by step” Science 2017, 358, 316. “Polymer chains grow one ‘hairball’ at a time” Nature 2017, 550 (7677), research highlights. “Single-molecule experiment reveals polymer growth spurts” Chem. Eng. News 2017, 95, 4. “Magnetic tweezers reveal ‘hairballs’ in polymer growth” Cornell Chronicle, Oct 19, 2017. “Close up view of growing polymer chain show jump steps” Phys.org, October 20, 2017. “Experiment shows that polymers grow in spurts” Compound Interest, This Week in Chemistry, Heavy elements made in neutron star collision, and real-time observation of polymer chain growth.
(53)	A. G. Santiago,^† T.-Y. Chen,^† L. Genova, W. Jung, A. Thompson, M. McEvoy, P. Chen* “Adaptor protein mediates dynamic pump assembly for bacterial metal efflux” Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 6694-6699. News highlights: “E. coli bacteria’s defense secret revealed” Cornell Chronicle, June 12, 2017. Also see Phys.org, ScienceDaily, Newswise, HiTechDays, Genetic Engineeing & Biotechnology News, EurekaAlert, ScienceNewsline, Innovations-Report, ScienMag. “Cellular Pumps Help E. Coli Beat Antibiotics,” Invisiverse, News of the Secret, Beautiful and Dangerous World of Microbes.
(52)	F. Yang, T.-Y. Chen, L. Krzeminski, A. G. Santiago, W. Jung, P. Chen* “Single-molecule dynamics of the molecular chaperone trigger factor in living cells” Mol. Microbiol. 2016, 102, 992-1003.
(51)	J. B. Sambur, P. Chen* “Distinguishing direct and indirect photoelectrocatalytic oxidation mechanisms using quantitative single-molecule reaction imaging and photocurrent measurements” J. Phys. Chem. C 2016, 120, 20668-20676. Invited contribution to the Richard P. Van Duyne Festschrift.
(50)	J. B. Sambur, T.-Y. Chen, E. Choudhary, G. Chen, E. J. Nissen, E. M. Thomas, N. Zou, P. Chen* “Sub-particle reaction and photocurrent mapping to optimize catalyst-modified photoanodes” Nature 2016, 530, 77-80. News highlights: “Water Splitting: Placing the catalyst where it’s needed” Science 2016, 351, 828. “Electrochemistry: Photocatalysts in close-up” Nature 2016, 530, 36-37. “Fluorescence Method Maps Reactivity Hot Spots On A Catalyst’s Surface” Chem. Eng. News 2016, 94, 8. “Researchers seek efficient means of splitting water” Cornell Chronicle, Feb 4, 2016; and at Phys.Org, Nanowerk, LabManager. “A ‘Hole’ New World: Improving the Efficiency of Water Splitting” Cornell Daily Sun, March 1, 2016.
(49)	T.-Y. Chen,^† W. Jung,^† A. G. Santiago, F. Yang, Ł. Krzemiński, P. Chen* “Quantifying multi-state cytoplasmic molecular diffusion in bacterial cells via inverse transform of confined displacement distribution” J. Phys. Chem. B 2015, 119, 14451-14459.
(48)	D. J. Martell, C. P. Joshi, A. Gaballa, A. G. Santiago, T.-Y. Chen, W. Jung, J. D. Helmann, P. Chen* “Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription” Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 13467-13472. News highlights: “Understanding Of Bacterial Protein’s Defense Strategy Could Lead To Antibiotics,” Chem. Eng. News 2015, 93, 7. Recommendation by Faculty of 1000 Prime.
(47)	T.-Y. Chen,^†A. G. Santiago,^† W. Jung, L. Krzeminski, F. Yang, D. J. Martell, J. D. Helmann, P. Chen* “Concentration and chromosome-organization dependent regulator unbinding from DNA for transcription regulation in living cells” Nature Commun. 2015, 6, 7445. DOI: 10.1038/ncomms8445. MATLAB code package: iQPALM (image-based quantitative photo-activated localization microscopy). figshare. Software. https://doi.org/10.6084/m9.figshare.12642617.v1 News highlights: “How Transcription Factors Depart Their Targets In Cells,” Chem. Eng. News 2015, 93, 25. “Research finds protein regulation linked to cells’ growth cycle,” Cornell Chronicle, July 2015.
(46)	H. Shen,^† X. Zhou,^† N. Zou, P Chen* “Single-Molecule Kinetics Reveals A Hidden Surface Reaction Intermediate in Single-Nanoparticle Catalysis” J. Phys. Chem. C 2014, 118, 26902-26911.
(45)	J. B. Sambur, P. Chen* “Approaches to Single-Nanoparticle Catalysis” Annu. Rev. Phys. Chem. 2014, 65, 395-422. Invited contribution.
(44)	P. Chen, X. Zhou, N. M. Andoy, K.-S. Han, E. Choudhary, N. Zou, G. Chen, H. Shen “Spatiotemporal Catalytic Dynamics within Single Nanocatalysts Revealed by Single-Molecule Microscopy” Chem. Soc. Rev.* 2014, 43, 1107-1117. Invited contribution to the themed issue “Single-molecule optical spectroscopy”.
(43)	P. Chen, A. M. Keller, C. P. Joshi, D. J. Martell, N. M. Andoy, J. J. Benítez, T.-Y. Chen, A. G. Santiago, F. Yang “Single-Molecule Dynamics and Mechanisms of Metalloregulators and Metallochaperones” Biochemistry 2013, 52, 7170-7183*. Invited Current Topic article.
(42)	M. A. Ochoa, P. Chen, R. F. Loring* “Single turnover measurements of nanoparticle catalysis analyzed with dwell time correlation functions and constrained mean dwell times” J. Phys. Chem. C 2013,117, 19074-19081.
(41)	X. Zhou, E. Choudhary, N. M. Andoy, N. Zou, P. Chen* “Scalable Parallel Screening of Catalyst Activity at the Single-Particle Level and Sub-diffraction Resolution” ACS Catal. 2013, 3, 1448-1453. News highlights: “Imaging method identifies most active catalyst particles” by Mitch Jacoby, Chemical & Engineering News, 2013, 91, 31.
(40)	N. M. Andoy, X. Zhou, E. Choudary, H. Shen, P. Chen* “Single-Molecule Catalysis Mapping Quantifies Site-specific Activity and Uncovers Radial Activity Gradient on Single 2D Nanocrystals” J. Am. Chem. Soc. 2013, 135, 1845-1852.
(39)	C. P. Joshi,^†D. Panda,^†D. J. Martell,^†N. M. Andoy, T.-Y. Chen, A. Gaballa, J. D. Helmann, P. Chen* “Direct Substitution and Assisted Dissociation Pathways for Turning Off Transcription by A MerR-family Metalloregulator” Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 15121-15126. News highlights: “Proteins barge in to turn off unneeded genes and save energy” by Bill Steele, Cornell Chronicle, September 5, 2012.
(38)	A. M. Keller, J. J. Benitez, D. Klarin, L. Zhong, M. Goldfogel, F. Yang, T.-Y. Chen, P. Chen* “Dynamic Multi-Body Protein Interactions Suggest Versatile Pathways for Copper Trafficking” J. Am. Chem. Soc. 2012, 134, 8934-8943.
(37)	Y.-F. Chen, X. Serey, R. Sarkar, P. Chen, D. Erickson* “Controlled photonic manipulation of proteins and other nanomaterials” Nano Lett. 2012, 12, 1633-1637.
(36)	K.-S. Han,^†G. Liu,^†X. Zhou, R. E. Medina, P. Chen* “How does A Single Pt Nanocatalyst Behave in Two Different Reactions? A Single-Molecule Study” Nano Lett. 2012, 12, 1253-1259.
(35)	X. Zhou, N. M. Andoy, G. Liu, E. Choudhary, K.-S. Han, H. Shen, P. Chen* “Quantitative Super-resolution Imaging Uncovers Reactivity Patterns on Single Nanocatalysts” Nature Nanotech. 2012, 7, 237–241. News highlights: “Study Reveals Understanding Surface Defects is Important to Design Better Fuel Cells” by Cameron Chai on Azom.com. “Catalytic Particles Feature Spatial-Activity Hot Spots” by Mitch Jacoby, Chemical and Engineering News, 2012, 90, 53. “Mapping the reactivity of single nanocatalysts” by Nina Notma, Chemistry World, February 22, 2012. “To make better fuel cells, study the defects” by Bill Steele, Cornell Chronicle, February 20, 2012.
(34)	P. Chen* “Solid Acid Catalysts: Stain and Shine” Nature Chem. 2011, 3, 839-840. Invited News and Views article.
(33)	M. A. Ochoa-Daza, X. Zhou, P. Chen, R. F. Loring* “Interpreting Single Turnover Catalysis Measurements with Constrained Mean Dwell Times” J. Chem. Phys. 2011, 135, 174509.
(32)	J. J. Benitez, A. M. Keller, D. L. Huffman, L. Yatsunyk, A. C. Rosenzweig, P. Chen* “Relating Dynamic Protein Interactions of Metallochaperones with Metal Transfer at the Single-Molecule Level” Faraday Discuss. 2011, 148, 71-82. Invited contribution to the special volume: Spectroscopy, Theory and Mechanism in Bioinorganic Chemistry.
(31)	P. Chen, X. Zhou, H. Shen, N. M. Andoy, E. Choudhary, K.-S. Han, G. Liu, W. Meng “Single-Molecule Fluorescence Imaging of Nanocatalytic Processes” Chem. Soc. Rev.* 2010, 39, 4560-4570. Invited Tutorial Review to the themed issue: In-situ characterization of heterogeneous catalysts.
(30)	H. Shen, W. Xu, P. Chen* “Single-Molecule Nanoscale Electrocatalysis” Phys. Chem. Chem. Phys. 2010, 12, 6555-6563. Invited Perspective article.
(29)	P. Chen, N. M. Andoy, J. J. Benitez, A. M. Keller, D. Panda, F. Gao “Tackling Metal Regulation and Transport at the Single-Molecule Level” Nat. Prod. Rep.* 2010, 27, 757-767. Invited review to the thematic issue of Metals in Cells.
(28)	J. J. Benitez, A. M. Keller, P. Chen* “Nanovesicle Trapping for Studying Weak Protein Interactions by Single-Molecule FRET” Meth. Enzymol. 2010, 472, 41-60. Invited article to the special volume of Single Molecule Tools: Fluorescence Based Approaches.
(27)	X. Zhou, W. Xu, G. Liu, D. Panda, P. Chen* “Size Dependent Catalytic Activity and Dynamics of Gold Nanoparticles at the Single-Molecule Level” J. Am. Chem. Soc. 2010, 132, 138-146.
(26)	W. Xu, H. Shen, G. Liu, P. Chen* “Single-Molecule Kinetics of Nanoparticle Catalysis” Nano Res. 2009, 2, 911-922. Invited review article.
(25)	N. M. Andoy, S. K. Sarkar, Q. Wang, D. Panda, J. J. Benitez, A. Kalininskiy, P. Chen* “Single-Molecule Study of Metalloregulator CueR-DNA Interactions Using Engineered Holliday Junctions” Biophys. J. 2009, 97, 844-852.
(24)	W. Xu, H. Shen, Y. J. Kim, X. Zhou, G. Liu, J. Park, P. Chen* “Single-Molecule Electrocatalysis by Single-Walled Carbon Nanotubes” Nano Lett. 2009, 9, 3968–3973. News highlights: “Finding how carbon nanotubes work as catalysts could lead to cleaner fuels” by Bill Steele, Cornell Chronicle. “Catalytic behaviour of SWCNTs scrutinised” Chemistry World Blog, April 20, 2009. “Pinpointing catalytic reaction sites on carbon nanotube walls” by Michael Berger, Nanowerk, April 21, 2009. “Single-Molecule Fluorescence Events Seen In Real Time” by Mitch Jacoby, Chemical & Engineering News, April 20, 2009, 87, 38.
(23)	P. Chen, W. Xu, X. Zhou, D. Panda, A. Kalininskiy “Single-Nanoparticle Catalysis at Single-Turnover Resolution” Chem. Phys. Lett.* 2009, 470, 151-157. Invited FRONTIERS article.
(22)	W. Xu, J. S. Kong, P. Chen* “Probing the Catalytic Activity and Heterogeneity of Au-Nanoparticles at the Single-Molecule Level” Phys. Chem. Chem. Phys. 2009, 11, 2767-2778. News highlights: Single nanocatalyst behavior revealed,” by Nina Notma, Chemistry World, February 18, 2009. “Picture perfect pentacene,” by James Mitchell Crow, Chemistry World, January 2011, 46-49.
(21)	W. Xu, J. S. Kong, P. Chen* “Single-Molecule Kinetic Theory of Heterogeneous and Enzyme Catalysis” J. Phys. Chem. C 2009, 113, 2393-2404.
(20)	P. Chen, N. M. Andoy “Single-Molecule Fluorescence Methods in Enzymology” In Comprehensive Natural Products Chemistry II Chemistry and Biology; Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford, 2010*; Vol. 9; pp 751. Invited review.
(19)	W. Xu, J. S. Kong, Y.-T. E. Yeh, P. Chen* “Single-Molecule Nanocatalysis Reveals Heterogeneous Reaction Pathways and Catalytic Dynamics” Nature Mater. 2008, 7, 992-996. News highlights: “Scrutinizing catalysts” by Mitch Jacoby, Chemical & Engineering News 2008, 86(46), 9. “When a good nanoparticle goes bad,” National Science Foundation press release. “New method can capture catalysis, one molecule at a time,” by Bill Steele, Cornell Chronicle. “When a good nanoparticle goes bad“, News highlights by Cornell Center for Materials Research. “Watching a catalyst at work” on New Energy and Fuel. “Gold study ‘could lead to smart catalysts being produced’” Gold News. Chemistry Today (in Japanese), February 2009, page 12. “Monitoring catalysis one particle at a time” Nanotechnology Alert, Jan 23, 2009, Frost & Sullivan.
(18)	J. J. Benítez, A. M. Keller, P. Ochieng, L. A. Yatsunyk, D. L. Huffman, A. C. Rosenzweig, P. Chen “Probing Transient Copper Chaperone-Wilson Disease Protein Interactions at the Single-Molecule Level with Nanovesicle Trapping” J. Am. Chem. Soc. 2008, 130, 2446-2447.
(17)	P. Chen, N. M. Andoy “Single-Molecule Fluorescence Studies from A Bioinorganic Perspective” Inorg. Chim. Acta 2008, 361*, 809-819. Invited contribution to the special issue in honor of Edward I. Solomon.
(16)	S. K. Sarkar, N. M. Andoy, J. J. Benítez, P. R. Chen, J. S. Kong, C. He, P. Chen* “Engineered Holliday Junctions as Single-Molecule Reporters for Protein-DNA Interactions with Application to a MerR-Family Regulator” J. Am. Chem. Soc. 2007, 129, 12461-12467.

	Postdoctoral and Graduate Publications
(15)	Nan, X.; Sims, P. A.; Chen, P.; Xie, X. S. “Observation of Individual Microtubule Motor Steps in Living Cells with Endocytosed Quantum Dots” J. Phys. Chem. B 2005, 109, 24220-24224. Press highlight: “Motor steps imaged in living cells”, Chemical & Engineering News, January 2, 2006, Volume 84, p22.
(14)	Solomon, E. I.; Basumallick, L.; Chen, P.; Kennepohl, P. “Variable Energy Photoelectron Spectroscopy: Electronic Structure and Electronic Relaxation” Coord. Chem. Rev. (Invited Issue of Synchrotron Radiation in Inorganic and Bioinorganic Chemistry), 2005, 249, 229-253.
(13)	Chen, P.; Solomon, E. I., “O₂Activation by Binuclear Cu Sites: Non-Coupled versus Exchange Coupled Reaction Mechanisms” Proc. Natl. Acad. Sci. USA 2004, 101, 13105-13110.
(12)	Chen, P.; Gorelsky, S. I.; Ghosh, S.; Solomon, E. I. “N₂O Reduction by the m₄-Sulfide Bridged Tetranuclear Cu_ZCluster Active Site” Angew. Chem. Int. Ed. 2004, 43, 4132-4140.
(11)	Chen, P.; Solomon, E. I., “Oxygen Activation by the Non-Coupled Binuclear Copper Site in Peptidylglycine a-Hydroxylating Monooxygenase. Reaction Mechanism and Role of the Non-Coupled Nature of the Active Site” J. Am. Chem. Soc. 2004, 126, 4991-5000.
(10)	Chen, P.; Bell, P.; Eipper, B. A.; Solomon, E. I. “Oxygen Activation by the Non-Coupled Binuclear Copper Site in Peptidylglycine a-Hydroxylating Monooxygenase. Spectroscopic Definition of the Resting Sites and the Putative Cu^II_M-OOH Intermediate” Biochemistry 2004, 43, 5735-5747.
(09)	Ghosh, S.; Gorelsky, S. I.; Chen, P.; Cabrito, I.; Moura, J. J. G.; Moura, I.; Solomon, E. I. “Activation of N₂O Reduction by the Fully Reduced m₄-Sulfide Bridged Tetranuclear Cu_ZCluster in Nitrous Oxide Reductase” J. Am. Chem. Soc. 2003, 125, 15708-15709.
(08)	Chen, P.; Fujisawa, K.; Helton, M. E.; Karlin, K. D.; Solomon, E. I. “Spectroscopy and Bonding in Side-On and End-On Cu₂(S₂) Cores: Comparison to Peroxide Analogues” J. Am. Chem. Soc. 2003, 125, 6394-6408.
(07)	Helton, M. E.; Chen, P.; Paul, P. P.; Tyeklár, Z.; Sommer, R.; Zhakarov, L.; Rheingold, A. L.; Solomon, E. I.; Karlin, K. D. “Reaction of Elemental Sulfur with a Copper(I) Complex Forming a trans-m-1,2 End-On Disulfide Complex: New Directions in Copper-Sulfide Chemistry” J. Am. Chem. Soc. 2003, 125, 1160-1161.
(06)	Chen, P.; Root, D. E.; Campochiaro, C.; Fujisawa, K.; Solomon, E. I. “Spectroscopic and Electronic Structure Studies of the Diamagnetic Side-On Cu^II-Superoxo Complex Cu(O₂)[HB(3-R-5-iPrpz)₃]: Antiferromagnetic Coupling versus Covalent Delocalization” J. Am. Chem. Soc. 2003, 125, 466-474.
(05)	Chen, P.; Cabrito, I.; Moura, J. J. G.; Moura, I.; Solomon, E. I. “Spectroscopic and Electronic Structure Studies of the m₄-Sulfide Bridged Tetranuclear Cu_ZCluster in N₂O Reductase: Molecular Insight into the Catalytic Mechanism” J. Am. Chem. Soc. 2002, 124, 10497-10507.
(04)	Chen, P.; George, S. D.; Cabrito, I.; Antholine, W. E.; Moura, J. J. G.; Moura, I.; Hedman, B.; Hodgson, K. E.; Solomon, E. I. “Electronic Structure Description of the m₄-Sulfide Bridged Tetranuclear Cu_ZCenter in N₂O Reductase” J. Am. Chem. Soc. 2002, 124, 744-745.
(03)	Chen, P.; Solomon, E. I. “Frontier Molecular Orbital Analysis of Cu_n-O₂Reactivity” J. Inorg. Biochem. (Invited 30th Anniversary Issue) 2002, 88, 368-374.
(02)	Solomon, E. I.; Chen, P.; Metz, M.; Lee, S. K., Palmer, A. E. “Oxygen Binding, Activation and Reduction to Water by Copper Proteins” Angew. Chem. Int. Ed. 2001, 40, 4570-4590; Angew. Chem. 2001, 113, 4702-4724.
(01)	Chen, P.; Fujisawa, K.; Solomon, E. I. “Spectroscopic and Theoretical Studies of Mononuclear Copper(II) Alkyl- and Hydroperoxo Complexes: Electronic Structure Contributions to Reactivity” J. Am. Chem. Soc. 2000, 122, 10177-10193.