Genomics and Bioinformatics Core Facilities at Cornell
Genomics requires access to advance and ever-changing technology to generate and to analyze data. At Cornell, we have outstanding core facilities available to faculty, staff, students and postdocs doing or planning genomic analysis of all scales and organisms. Outstanding, state-of-the-art Genomics shared core facilities are provided by Cornell’s Biotechnology Resource Center (BRC) which maintains an array of genomic, proteomics, imaging and informatics shared research resources and Core Laboratory services to the university community.
Genomics Facility provides a broad array of instrumentation and services, including Sanger sequencing of plasmid and PCR products on the Life Technology/ABI 3730×1 capillary array sequencing platform, and a range of next generation sequencing instruments, such as the Illumina MiSeq and Illumina HiSeq 2000/2500 platforms. The facility also provides high throughput genotyping and gene expression services using the Illumina, Affymetrix and Agilent microarray platforms, plus real-time PCR system.
Bioinfomatics Facility offers resources, services and training in computational biology and bioinformatics through collaborative research and consultation, and by providing easily accessible advanced computational software, data storage and analysis platforms and expertise in their use and applications. The Bio-IT facility is under the umbrella of the Bioinformatics Facility whose activities include providing the BRC core facilities with enterprise information technology (IT) infrastructure, laboratory information management systems, and data management and analysis services. The facility also provides desktop and network support, software license management to a diverse array of investigators in the Cornell University life sciences research community.
Other Genomics Related Core Facilities at Cornell
The RNA sequencing Core Facility offers resources, services and training in computational biology and bioinformatics through collaborative research and consultation, and by providing easily accessible advanced computational software, data storage and analysis platforms and expertise in their use and applications. As of July 2017, the activites of the former Bio-IT facility have been moved under the umbrella of the Bioinformatics Facility. These activities include providing the BRC core facilities with enterprise information technology (IT) infrastructure, laboratory information management systems, and data management and analysis services. The facility also provides desktop and network support, software license management to a diverse array of investigators in the Cornell University life sciences research community.
The Proteomics Core Facility provides investigators with cutting edge technologies for proteomic analyses. Services include 2D gel and 2D LC separation for macromolecules; robotic and manual sample preparation for proteomics samples; protein identification; quantitative proteomics by 2D DIGE analysis or shotgun-based iTRAQ; and characterization of post-translational modifications (PTMs) through both non-targeted and targeted discovery approaches. Services also include small molecule profiling, quantitation and data interpretation.
The Imaging Core Facility resources and services include high resolution X-ray computed tomography (CT), flow cytometry, confocal microscopy, light microscopy, multiphoton microscopy, laser capture microdissection, bioluminescence imaging, high resolution ultrasound imaging, spectrofluorometry, and image visualization and analysis software. The facility also provides consultation on project design, instrument use, and image data analysis and visualization, and offers educational workshops and training.
The Metabolomics Core Facility provides investigators with cutting edge technologies for metabolomics analyses. Services include Untargeted metabolomics profiling for discovery screens, Metabolic Flux analysis, Targeted metabolomics profiling for validation, Targeted small molecules analysis for relative/absolute quantitation, Metabolite separation by UPLC and GC, Sample preparation, and consultation for experimental design and data analysis.