Selected Publications

Phosphorylation of c-Cbl and p85 PI3K driven by all-trans retinoic acid and CD38 depends on Lyn kinase activity. Congleton J, Shen M, Macdonald R, Malavasi F, Yen A. Cell Signal. 2014 Mar 29;26(7):1589-1597.

Revealing CD38 Cellular Localization Using a Cell Permeable, Mechanism-Based Fluorescent Small-Molecule Probe. Shrimp JH, Hu J, Dong M, Wang BS, Macdonald R, Jiang H, Hao Q, Yen A, Lin H. J Am Chem Soc. 2014 Apr 7. [Epub ahead of print]

Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation. Geil WM, Yen A. FEBS J. 2014; 281(4):1170-1180.

The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells. Jensen HA, Styskal LE, Tasseff R, Bunaciu RP, Congleton J, Varner JD, Yen A. PLoS One. 2013;8(3):e58621

6-Formylindolo (3,2-b)carbazole (FICZ) enhances retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells. Bunaciu RP, Yen A. Mol Cancer. 2013 May 9;12:39

Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells. Congleton J, MacDonald R, Yen A. Leukemia. 2012 Jun;26(6):1180-8

ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary. Congleton J, Jiang H, Malavasi F, Lin H, Yen A. Exp Cell Res. 2011 Apr 15;317(7):910-9.

Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells. Shen M, Bunaciu RP, Congleton J, Jensen HA, Sayam LG, Varner JD, Yen A. Leuk Lymphoma. 2011 Dec;52(12):2372-9.

Activation of the aryl hydrocarbon receptor AhR Promotes retinoic acid-induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell transcription factor Oct4. Bunaciu RP, Yen A. Cancer Res. 2011 Mar 15;71(6):2371-80.

Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells. Tasseff R, Nayak S, Song SO, Yen A, Varner JD. Integr Biol (Camb). 2011 May;3(5):578-91

Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells. Nayak S, Shen M, Bunaciu RP, Bloom SE, Varner JD, Yen A. Leuk Lymphoma. 2010 Sep;51(9):1734-4

RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition. Reiterer G, Chen L, Tassef R, Varner JD, Chen CY, Yen A. Cell Cycle. 2010 Aug 15;9(16):3297-304.

c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest. Shen M, Yen A. J Biol Chem. 2009 Sep 18;284(38):25664-77

Nicotinamide cooperates with retinoic acid and 1,25-dihydroxyvitamin D(3) to regulate cell differentiation and cell cycle arrest of human myeloblastic leukemia cells. Shen M, Yen A. Oncology. 2009;76(2):91-100.

Mechanism-based small molecule probes for labeling CD38 on live cells. Jiang H, Congleton J, Liu Q, Merchant P, Malavasi F, Lee HC, Hao Q, Yen A, Lin H. J Am Chem Soc. 2009 Feb 11;131(5):1658-9.

c-Cbl interacts with CD38 and promotes retinoic acid-induced differentiation and G0 arrest of human myeloblastic leukemia cells. Shen M, Yen A. Cancer Res. 2008 Nov 1;68(21):8761-9.

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