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  Cornell University

MAE Publications and Papers

Sibley School of Mechanical and Aerospace Engineering

New article: Characterization of Tissue Response to Impact Loads Delivered Using a Hand-Held Instrument for Studying Articular Cartilage Injury

Article:  Bonnevie, Edward D.; Delco, Michelle L.; Fortier, Lisa A.; Alexander, Peter G.; Tuan, Rocky S.; Bonassar, Lawrence J.; (2015)  “Characterization of Tissue Response to Impact Loads Delivered Using a Hand-Held Instrument for Studying Articular Cartilage Injury”, Cartilage, 6 (4):226-232

DOI

Abstract:  Objective: The objective of this study was to fully characterize the mechanics of an in vivo impactor and correlate the mechanics with superficial cracking of articular surfaces. Design: A spring-loaded impactor was used to apply energy-controlled impacts to the articular surfaces of neonatal bovine cartilage. The simultaneous use of a load cell and displacement sensor provided measurements of stress, stress rate, strain, strain rate, and strain energy density. Application of India ink after impact was used to correlate the mechanical inputs during impact with the resulting severity of tissue damage.

Additionally, a signal processing method to deconvolve inertial stresses from impact stresses was developed and validated. Results: Impact models fit the data well (root mean square error average similar to 0.09) and provided a fully characterized impact. Correlation analysis between mechanical inputs and degree of superficial cracking made visible through India ink application provided significant positive correlations for stress and stress rate with degree of surface cracking (R-2 = 0.7398 and R-2 = 0.5262, respectively). Ranges of impact parameters were 7 to 21 MPa, 6 to 40 GPa/s, 0.16 to 0.38, 87 to 236 s(-1), and 0.3 to 1.1

MJ/m(3) for stress, stress rate, strain, strain rate, and strain energy density, respectively. Thresholds for damage for all inputs were determined at 13 MPa, 15 GPa/s, 0.23, 160 s(-1), and 0.59 MJ/m(3) for this system. Conclusions: This study provided the mechanical basis for use of a portable, sterilizable, and maneuverable impacting device. Use of this device enables controlled impact loads in vitro or in vivo to connect mechanistic studies with long-term monitoring of disease progression.

Funding Acknowledgement:  National Science Foundation Graduate Research Fellowship Program, National Institutes of Health [Z01 AR41131, T32 RR007059]; Commonwealth of Pennsylvania Department of Health [SAP 4100050913]; Harry M. Zweig Foundation for Equine Research

Funding Text:  The authors gratefully acknowledge financial support from the National Science Foundation Graduate Research Fellowship Program, National Institutes of Health (Z01 AR41131 and T32 RR007059), Commonwealth of Pennsylvania Department of Health (SAP 4100050913), and the Harry M. Zweig Foundation for Equine Research.

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