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  Cornell University

MAE Publications and Papers

Sibley School of Mechanical and Aerospace Engineering

New article: Three-dimensional characterization of resorption cavity size and location in human vertebral trabecular bone

Article: Goff MG, Slyfield CR, Kummari SR, Tkachenko EV, Fischer SE, Yi YH, Jekir MG, Keaveny TM and Hernandez CJ (2012). “Three-dimensional characterization of resorption cavity size and location in human vertebral trabecular bone.” Bone 51(1): 28-37.

DOI

Abstract: The number and size of resorption cavities in cancellous bone are believed to influence rates of bone loss, local tissue stress and strain and potentially whole bone strength. Traditional two-dimensional approaches to measuring resorption cavities in cancellous bone report the percent of the bone surface covered by cavities or osteoclasts, but cannot measure cavity number or size. Here we use three-dimensional imaging (voxel size 0.7 x 0.7x 5.0 mu m) to characterize resorption cavity location, number and size in human vertebral cancellous bone from nine elderly donors (7 male, 2 female, ages 47-80 years). Cavities were 30.10 +/- 8.56 mu m in maximum depth, 80.60 +/- 22.23(*)10(3) mu m(2) in surface area and 614.16 +/- 311.93(*)103 mu m(3) in volume (mean +/- SD). The average number of cavities per unit tissue volume (N.Cv/TV) was 1.25 +/- 0.77 mm(-3). The ratio of maximum cavity depth to local trabecular thickness was 30.46 +/- 7.03% and maximum cavity depth was greater on thicker trabeculae (p<0.05, r(2)=0.14). Half of the resorption cavities were located entirely on nodes (the intersection of two or more trabeculae) within the trabecular structure. Cavities that were not entirely on nodes were predominately on plate-like trabeculae oriented in the cranial-caudal (longitudinal) direction. Cavities on plate-like trabeculae were larger in maximum cavity depth, cavity surface area and cavity volume than cavities on rod-like trabeculae (p<0.05). We conclude from these findings that cavity size and location are related to local trabecular microarchitecture. (C) 2012 Elsevier Inc. All rights reserved.

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